DRSC/TRiP Functional Genomics Resources

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Protein Alignment smog and Gpr158

DIOPT Version :10

Sequence 1:NP_001245881.1 Gene:smog / 33690 FlyBaseID:FBgn0051660 Length:951 Species:Drosophila melanogaster
Sequence 2:NP_001004761.1 Gene:Gpr158 / 241263 MGIID:2441697 Length:1200 Species:Mus musculus


Alignment Length:902 Identity:230/902 - (25%)
Similarity:359/902 - (39%) Gaps:183/902 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   128 YSLLVLLI---VGLATATASPSP-----SP-SHAPFGRESRRDALLAYYKRAHLPQS-SSSGISL 182
            ||||..|:   :||....||..|     || ...|.|::..:....|......:|.| |:.|..|
Mouse     6 YSLLFCLLLAHLGLGEVGASLDPPGRPDSPRERTPRGKQHGQQLPRASAPDPSIPWSRSTDGTIL 70

  Fly   183 GHK-----------------YHLLHDANGLDFDELTPTASSVSALSRAERFRLRKRSATPTTPAT 230
            ..|                 :|.|..||               ...|.|...|..:|     |:.
Mouse    71 AQKLAEEVPVDVASYLYTGDFHQLKRAN---------------CSGRYELAGLPGKS-----PSL 115

  Fly   231 AAGVTSLDVA-TAAAAATDAAAKDAGSGKKPEEKCEPK-------VLETLPDEPFYDYTDIAEDA 287
            |:...||..| .....||:.......|.|..|:..:..       |...|..||         ..
Mouse   116 ASSHPSLHGALDTLTHATNFLNMMLQSNKSREQTVQDDLQWYQALVRSLLEGEP---------SI 171

  Fly   288 ARQFIEFLSGKFPNANTPIAIDEPTRAEVSRRANGIASYALNEDDNLLAFAIAAPSIHTVVVKFR 352
            :|..|.|.:   .:.:||              |..:...|..|:..:|...:::.:.|..     
Mouse   172 SRAAITFST---ESLSTP--------------APQVFLQATREESRILLQDLSSSAHHLA----- 214

  Fly   353 DNVTIPPDQVHNKAYLGSYWRE-------------LGAAWNSTDGT------QEWGAPFRDCNLL 398
             |.|:..:..|.   |...||.             ||.:|...||.      .:|..|:.:|...
Mouse   215 -NATLETEWFHG---LRRKWRPHLHRRGSNQGPRGLGHSWRRRDGLGGDRSHVKWSPPYLECENG 275

  Fly   399 TRR--WLWPFRISF--------SEHR-IKVVAAAFIAADEDVC-NDGLEEVFGRRHGCDRNTTFC 451
            :.:  ||.....:|        .|.| :..|..:....|.|.| :||.   |...|.|..|.:.|
Mouse   276 SYKPGWLVTLSAAFYGLQPNLVPEFRGVMKVDISLQKVDIDQCSSDGW---FSGTHKCHLNNSEC 337

  Fly   452 LLTENKPAATRDVYTCLCRESYYLP------NSTLQG----FRGDRVELSEGYDNYSCIPCPGGC 506
            :..:.. ......|.|:|:..:|.|      |...:|    |.|...::||  :.:.|:||..||
Mouse   338 MPIKGL-GFVLGAYQCICKAGFYHPRVFSVNNFQRRGPDHHFSGSTKDVSE--ETHVCLPCREGC 399

  Fly   507 TNCDSNGVCLTFQEEEVLNVDACLRLLVAIVLGACILCCIVLGVIVFRQRKCKAI-ASGMWTVLE 570
            ..|..:..|  |.:|     |..|||.:......|:|...|..::|:..||.|:| |||: .:||
Mouse   400 PFCADDRPC--FVQE-----DKYLRLAIISFQALCMLLDFVSMLVVYHFRKAKSIRASGL-ILLE 456

  Fly   571 TILLGIVLLYASVAVHFFPASTERCLLEPWLRELGFITCYGAIILKLYRHLVDFRTRKAHRW-VL 634
            |||.|.:|||..|.:.:|..||.||:|..|.|.|||.|.||.:.|||:|.|..|.:|.|.|. .:
Mouse   457 TILFGSLLLYFPVVILYFEPSTFRCILLRWARLLGFATVYGTVTLKLHRVLKVFLSRTAQRIPYM 521

  Fly   635 RDVDLLKYLGTMVFAVICYMAAFTAS-----SLDLLESAQLESLREADTNTCHPLKWELVTQTSE 694
            ....:::.|..:|..|..::..:|:|     ..|:|...|.::......|.|...:|:.:|..:|
Mouse   522 TGGRVMRMLAVIVLVVFWFLVGWTSSMCQNLERDILLVGQGQTSDHLTFNMCLIDRWDYMTAVAE 586

  Fly   695 MLILCFGLHLSIASRNANTQFRERQFLVTALTLEFLVSSSFYFLRFVYLPEMSPSAILLALFIRS 759
            .|.|.:|::|..|.|...:.|.|.:::..|:..|.::::.|:.:|||....:.|..:|:..|..:
Mouse   587 FLFLLWGIYLCYAVRTVPSAFHEPRYMAVAVHNELIITAIFHTIRFVLASRLQPDWMLMLYFAHA 651

  Fly   760 QLTNSFALGLIFVPKLWYQHKQVRSLAYDLSIRLPVDAFKGTSHDAGQRLGGGYAGLCLGDPDIG 824
            .||.:..:||:.:||..:.....|.   |::    .:|::       ..|..|.:|..|......
Mouse   652 HLTVTVTIGLLLIPKFSHSSNNPRD---DIA----TEAYE-------DELDMGRSGSYLNSSINS 702

  Fly   825 ELTISEMSPEDIRAELKRLYTQLEIMKNKTLRQDNPHISKRRGGRKAGHRRF---------SLQK 880
            ..:...:.|||||.|||:||.||||.|.|.:..:|||:.|:|..:|...|..         ::.:
Mouse   703 AWSEHSLDPEDIRDELKKLYAQLEIYKRKKMITNNPHLQKKRCSKKGLGRSIMRRITEIPETVSR 767

  Fly   881 KGSKDKALSAKHRSNKHHQDIEITEAEPS----RTPEDS----VCSAEGPTDTYAEI 929
            :.||:......|.:.|....:.....|.|    |..|:|    |.|.:....||..:
Mouse   768 QCSKEDKEGTDHSAAKGTGLVRKNPTESSGNTGRPKEESLKNRVFSLKKSHSTYDHV 824

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smogNP_001245881.1 7tmC_GPR158-like 529..780 CDD:320420 83/257 (32%)
TM helix 1 529..554 CDD:320420 7/24 (29%)
TM helix 2 566..587 CDD:320420 10/20 (50%)
TM helix 3 596..620 CDD:320420 12/23 (52%)
TM helix 4 639..659 CDD:320420 3/19 (16%)
TM helix 5 683..709 CDD:320420 8/25 (32%)
TM helix 6 717..740 CDD:320420 4/22 (18%)
TM helix 7 749..774 CDD:320420 6/24 (25%)
Gpr158NP_001004761.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 25..62 8/36 (22%)
Cache-like region. /evidence=ECO:0000250|UniProtKB:Q5T848 85..281 46/250 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 234..253 3/18 (17%)
7tmC_GPR158-like 415..672 CDD:320420 83/257 (32%)
TM helix 1 415..440 CDD:320420 7/24 (29%)
TM helix 2 452..473 CDD:320420 10/21 (48%)
TM helix 3 482..506 CDD:320420 12/23 (52%)
TM helix 4 526..546 CDD:320420 3/19 (16%)
TM helix 5 575..601 CDD:320420 8/25 (32%)
TM helix 6 609..632 CDD:320420 4/22 (18%)
TM helix 7 641..666 CDD:320420 6/24 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 757..875 13/68 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 947..988
VCPWE motif 1. /evidence=ECO:0000250|UniProtKB:Q5T848 1000..1004
VCPWE motif 2. /evidence=ECO:0000250|UniProtKB:Q5T848 1065..1069
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1130..1160
VCPWE motif 3. /evidence=ECO:0000250|UniProtKB:Q5T848 1165..1169
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1177..1200
Blue background indicates that the domain is not in the aligned region.

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