DRSC/TRiP Functional Genomics Resources

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Protein Alignment smog and Gpr179

DIOPT Version :10

Sequence 1:NP_001245881.1 Gene:smog / 33690 FlyBaseID:FBgn0051660 Length:951 Species:Drosophila melanogaster
Sequence 2:NP_001074689.1 Gene:Gpr179 / 217143 MGIID:2443409 Length:2293 Species:Mus musculus


Alignment Length:565 Identity:174/565 - (30%)
Similarity:254/565 - (44%) Gaps:95/565 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   379 WNSTDG------TQEWGAPFRDCNLLTRRWLWPFRISFSEHRIKVVAAAFI-----------AAD 426
            |...||      ..:...||.:|:....|..|...:|.:.:.:|......:           :.|
Mouse   214 WPRGDGYVGDIQQVKLSPPFLECHEGQLRPGWLVTVSATFYGLKPDLTPEVRGQVQMDIDLQSVD 278

  Fly   427 EDVCNDGLEEVFGRRHGCDRNTTFCLLTENKPAATRDVYTCLCRESYY-------LPNSTLQG-- 482
            .:.|..| ...:...|.||.|:|.|:..|:: ......|.|.||..:|       |..|..|.  
Mouse   279 INQCASG-PGWYSNTHLCDLNSTQCVPLESQ-GFVLGRYLCRCRPGFYGASGSGGLEESATQAAG 341

  Fly   483 -FRGDRVELSEGYDNYSCIPCPGGCTNCDSNGVCLTFQEEEVLNVDACLRLLVAIVLGACILCC- 545
             |...:..|.:   ...|.|||.|||:|.....||         |:..|.|..|::  ||..|| 
Mouse   342 QFGSPQDSLGK---LLRCQPCPEGCTSCLDATPCL---------VEEALALRTAVL--ACQACCM 392

  Fly   546 --IVLGVIV-FRQRKCKAI-ASGMWTVLETILLGIVLLYASVAVHFFPASTERCLLEPWLRELGF 606
              :.|.::| :|.|..|.| |||: .:|||||.|.:|||..|.:.:|..|..||:...|:|.|||
Mouse   393 LAVFLSMLVAYRCRGSKRIRASGI-VLLETILFGSLLLYFPVFILYFKPSVFRCVALRWVRLLGF 456

  Fly   607 ITCYGAIILKLYRHLVDFRTRKAHRWVLRDV------DLLKYLGTMVFAVICYMAAFTASSLDLL 665
            ...||.|||||||.|..|.:|.|.|     |      .||:.||.::..|:.::..:||.:|:  
Mouse   457 AVVYGTIILKLYRVLQLFLSRTAQR-----VPHPSSGQLLRRLGQLLLLVLGFLVVWTAGALE-- 514

  Fly   666 ESAQLESL-READTNT------CHPLKWELVTQTSEMLILCFGLHLSIASRNANTQFRERQFLVT 723
            ...|..:| ....|.|      ||...|:.:...:|||:||:|..|..|:|...:.|.|.:::..
Mouse   515 PGTQHTALVTRGHTPTGRHFYLCHHDHWDYIMVVAEMLLLCWGSFLCYATRAVPSAFHEPRYMSI 579

  Fly   724 ALTLEFLVSSSFYFLRFVYLPEMSPSAILLALFIRSQLTNSFALGLIFVPKLWY----QHKQVRS 784
            ||..|.|:|::|:..|||.:|.:.|...||..|:.:..|.:..|.|||:||.|.    ..:::..
Mouse   580 ALHNELLLSTAFHTARFVLVPSLHPDWTLLLFFLHTHSTVTATLALIFIPKFWKPGAPPREEILD 644

  Fly   785 LAYDLSIRLPVDAFKGTSHDAGQRLGGGYAGLCLGDPDIGELTISEMS--PEDIRAELKRLYTQL 847
            ..|:..:.|             || .|.|....:..      ..||.|  |.|||.|||:||.||
Mouse   645 EVYEDELDL-------------QR-SGSYLNSSIAS------AWSERSLEPGDIRDELKKLYAQL 689

  Fly   848 EIMKNKTLRQDNPHISKRRGGRKAGHRRFSLQKKGSKDKALSAKH 892
            ||.|.|.:..:|||:.|:||....|..|..::......:||:.:|
Mouse   690 EIRKTKEMAANNPHLPKKRGSSHQGLGRSFMRYLAEFPEALARQH 734

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smogNP_001245881.1 7tmC_GPR158-like 529..780 CDD:320420 98/272 (36%)
TM helix 1 529..554 CDD:320420 9/28 (32%)
TM helix 2 566..587 CDD:320420 10/20 (50%)
TM helix 3 596..620 CDD:320420 13/23 (57%)
TM helix 4 639..659 CDD:320420 5/19 (26%)
TM helix 5 683..709 CDD:320420 9/25 (36%)
TM helix 6 717..740 CDD:320420 7/22 (32%)
TM helix 7 749..774 CDD:320420 8/24 (33%)
Gpr179NP_001074689.1 Cache-like region. /evidence=ECO:0000250|UniProtKB:Q5T848 62..245 7/30 (23%)
EGF_CA 278..327 CDD:238011 15/50 (30%)
7tmC_GPR158-like 379..632 CDD:320420 96/262 (37%)
TM helix 1 379..404 CDD:320420 8/26 (31%)
TM helix 2 416..437 CDD:320420 10/21 (48%)
TM helix 3 446..470 CDD:320420 13/23 (57%)
TM helix 4 490..510 CDD:320420 5/19 (26%)
TM helix 5 539..565 CDD:320420 9/25 (36%)
TM helix 6 573..596 CDD:320420 7/22 (32%)
TM helix 7 605..630 CDD:320420 8/24 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 733..812 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 872..935
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1046..1235
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1275..1294
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1326..1345
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1388..1411
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1479..1560
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1578..1770
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1792..1828
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1844..1882
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1924..2051
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2212..2293
Blue background indicates that the domain is not in the aligned region.

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