DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smog and gpr179

DIOPT Version :9

Sequence 1:	NP_001245881.1	Gene:	smog / 33690	FlyBaseID:	FBgn0051660	Length:	951	Species:	Drosophila melanogaster
Sequence 2:	XP_017213785.2	Gene:	gpr179 / 100537469	ZFINID:	ZDB-GENE-120229-1	Length:	1792	Species:	Danio rerio

Alignment Length:	877	Identity:	225/877 - (25%)
Similarity:	361/877 - (41%)	Gaps:	184/877 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 LHDANGLDFDELTPTA----SSVSALSRAERFRLRKRSATPTTPATAAGVTSLDVATAAA----- 244
            |.|.:.|:|   |||.    .:::|          .:..:|:..||:....:::..:||.
Zfish    28 LKDTSSLEF---TPTPFLTDPNITA----------GKGLSPSPQATSLPPVTVEDRSAAESYLYN 79

  Fly   245 --AATDAAAKDAGSGKKPEEKCEP---------KVLETLPDEP-----FYDYTDIAEDAARQFIE 293
              :::.||:....:.:.|..:..|         :.:.:|.:..     .:..:::.|.:.|:.||
Zfish    80 GDSSSLAASTCTRTFQLPVRRGPPPRDLLPLLHQAIASLTNAANFLNLIFQASELRETSVREDIE 144

  Fly   294 F--------LSGKFPN--ANTPIAID-EPTRAE---VSRRANGIASYALNED------------- 331
            :        |.|..|.  ....:..| :||..:   |.|.:.|.....|.:|
Zfish   145 WYHALVRTMLEGDRPGLVRRAFLTFDADPTIQQPQLVLRASKGTTQDILLQDLTSAWTSFRPPAP 209

  Fly   332 -----DNLLAFAIAAPSIHTVV--VKFRDNVTI-PPDQVHNKAYLGSYWRELGAAWNSTDGTQEW 388
                 |   .|..::|.:|.:.  |...|..|: .|......:|:           .::.|.| |
Zfish   210 DQSWFD---IFKSSSPPLHALSKRVLLNDLSTLDTPKWARGDSYV-----------INSSGVQ-W 259

  Fly   389 G-APFRDCNLLTRRWL--WPFRISFSEH--------------RIKVVAAAFIAADEDVCNDGLEE 436
            | .||.:|  :..|:|  |...:|...:              |:.|....|   ..|.|..| :.
Zfish   260 GEGPFLEC--VDGRFLPGWLLSLSMPFYGLKPDLSPEFRGVIRVDVNIQGF---SVDQCATG-DF 318

  Fly   437 VFGRRHGCDRNTTFCLLTENKPAATRDV----YTCLCRESYYLPNSTLQGFRGDRVELSEG-YDN 496
            .|...|.|:|.:..|     :|...:..    |.|.|::.||.|.|.:|..|.:|...::. |..
Zfish   319 WFANTHQCNRTSMEC-----EPIPQKGFRMGQYCCRCKKGYYSPISDIQNKRNNRENNTQACYPE 378

  Fly   497 YS-CIPCPGGCTNCDSNGVCLTFQEEEVLNVDACLRLLVAIVLGACILCCIVLGVIVFRQRKCKA 560
            .. |:||..||..|:....|.. ||      |..||..|..|.|..::..::..::.::.||.|.
Zfish   379 VPVCVPCWPGCAECEDGAPCWV-QE------DWLLRTAVLAVQGLFMILVLISMLVAYQCRKTKR 436

  Fly   561 IASGMWTVLETILLGIVLLYASVAVHFFPASTERCLLEPWLRELGFITCYGAIILKLYRHLVDFR 625
            |.|....:||.||.|.:|||..|.:.:|..||.||:|..|:|.|||...||.:.||:||.|..|.
Zfish   437 IRSSGLLLLEMILCGSLLLYFPVFILYFKPSTFRCILLRWVRLLGFAIVYGTVALKMYRVLKVFL 501

  Fly   626 TRKAHRW-VLRDVDLLKYLGTMVFAVICYMAAFTASSLD--------LLESAQLESLREADTNTC 681
            :|.|.|. .:....:|:.||.||..|..::.|:|...|.        |:.|...|.   ...|.|
Zfish   502 SRTAQRVPYITTTGVLRMLGVMVLTVSWFLCAWTVGVLQNRDRNVPLLIISTTSEG---QGFNVC 563

  Fly   682 HPLKWELVTQTSEMLILCFGLHLSIASRNANTQFRERQFLVTALTLEFLVSSSFYFLRFVYLPEM 746
            ...:|:.:...:|:|.||:|..|..|.:...:.|.|.:::..|:..|.|:||.|:.|||. .|.:
Zfish   564 DLDRWDYMMAVAELLFLCWGSFLCSAVKTVPSAFHEPRYMSIAIHNELLLSSMFHLLRFA-RPSI 627

  Fly   747 SPSAILLALFIRSQLTNSFALGLIFVPKLWYQ----HKQVRSLAYDLSIRLPVDAFKGTSHDAGQ 807
            .|..:||..|..:.:|.:..|||:||||..:.    .:::.:..|:..    ||..:..|:
Zfish   628 HPDWMLLLFFTHTHVTITVTLGLLFVPKFLHMSRPGREEIAAEVYEDE----VDLRRSCSY---- 684

  Fly   808 RLGGGYAGLCLGDPDIGELTISEMSPEDIRAELKRLYTQLEIMKNKTLRQDNPHISKRRGGRKAG 872
             |...:...|..|        ..:.|:|||.|||:||:|||:.|.|.:...|||:.|:|..|.:.
Zfish   685 -LNSSFTSNCWSD--------QSLDPDDIRDELKKLYSQLEVHKTKRMANSNPHLPKKRSSRLSI 740

  Fly   873 HRRF---------SLQKKGSK-DKALSAK----HRSN---KHHQDIEI-TEAEPSRTPEDSVCSA 919
            .|..         ||.::.|: ||.:||.    .||.   |.||...| |..|....|...:..:
Zfish   741 GRSIIKRISEIPESLSRQCSREDKDISAAIGTITRSGSYYKCHQTTSINTINETLMQPSPKLRKS 805

  Fly   920 EGPTDTYAEISGVSHSMLSHSMVSHSVVSHSK 951
            ....|...|...   |:|:.||...:...||:
Zfish   806 HSAYDCTPEKEA---SLLNSSMKRSTEKRHSQ 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smog	NP_001245881.1	7tm_3	542..776	CDD:278433	82/242 (34%)
gpr179	XP_017213785.2	7tmC_GPR158-like	405..661	CDD:320420	87/259 (34%)
		TM helix 1	405..430	CDD:320420	5/24 (21%)
		TM helix 2	442..463	CDD:320420	9/20 (45%)
		TM helix 3	472..496	CDD:320420	11/23 (48%)
		TM helix 4	516..536	CDD:320420	7/19 (37%)
		TM helix 5	565..591	CDD:320420	8/25 (32%)
		TM helix 6	599..622	CDD:320420	8/22 (36%)
		TM helix 7	630..655	CDD:320420	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103956
Panther	1	1.100	-	-	O	PTHR32546
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910