DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mon1 and Mon1b

DIOPT Version :9

Sequence 1:	NP_608868.1	Gene:	Mon1 / 33689	FlyBaseID:	FBgn0031640	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	XP_006255736.1	Gene:	Mon1b / 307868	RGDID:	1309977	Length:	583	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	185/527 - (35%)
Similarity:	276/527 - (52%)	Gaps:	55/527 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NSTCEYLDAEGDPESPNLYQEADPDQEAEQQNHSIISELRDGLGTMRDNSALSPEPGQENKGLAA 77
            :||||:........||.    .:|.:.:|.|.    .:..||.....|.|...|..|..|.|
  Rat    71 SSTCEHWKTAASDSSPT----GEPQRSSEGQG----EDPSDGDPNDGDPSDGDPNDGDPNDG--- 124

  Fly    78 SVESLALSTSTSAKTEDSIGGGLEEEYDYQHDSLWQGQKKHIFILSEAGKPIFSLHGNEDKLATL 142
                      ..:..:.:.|...:|:        |:.|:||:|:||||||||:|.:|:.:.|:..
  Rat   125 ----------DPSDGDPNDGDPSDED--------WRSQRKHVFVLSEAGKPIYSRYGSVEALSAT 171

  Fly   143 FGVIQALVSFVQMGQDAITSIHAGGIKFAFMQRSSLILVAASRSNMSVQQLQLQLGDVYNQILSI 207
            .||:.|||||||...|||.:|:|...|..|:|:..|:|||.||:..|..||:.:|..|:.||:|.
  Rat   172 MGVMTALVSFVQSAGDAIRAIYAEDHKLVFLQQGPLLLVAVSRTPQSAAQLRGELLAVHAQIVST 236

  Fly   208 LTYSHMTKIFERRKNFDLRRLLSGSERLFYNLLANDSSSAKVSNNIFTFLTNSIRVFPLPTTIRS 272
            ||.:.:.:||..::|:||||||:||||....||  ||    |..:....|..::|..||...:|.
  Rat   237 LTRASVARIFAHKQNYDLRRLLAGSERTLDRLL--DS----VEQDPGALLLGAVRCVPLARPLRD 295

  Fly   273 QITSAIQSNCSKIKNLVFAVLIANNKLIALVR----MKKYSIHPADLRLIFNLVECSESFKSSEN 333
            .:.:.:: .|: ...|..:||....:||...:    :.:..:.||||:|:.:.|. :.:|.:.|.
  Rat   296 ALGTLLR-RCT-APGLALSVLAVGGRLITAAQERNVLAECRLDPADLQLLLDWVG-APAFAAGEA 357

  Fly   334 WSPICLPKFDMNGYLHAHVSYLADDCQACLLLLSVDRDAFFTLAEAKAKITEKLRKSHCLEAINE 398
            |:|:|||:|:.:|:.:|:|:.| |....|||||..:|:||..:|..:..:.:.:.....|..:.|
  Rat   358 WAPVCLPRFNPDGFFYAYVARL-DSMPVCLLLLGTNREAFHAMAACRRLVEDGMHNLGALRTLGE 421

  Fly   399 ELQ----QPFNAKLYQ-QVVGIPELRHFLYKP-------KSTAQLLCPMLRHPYKSLTELERLEA 451
            ...    ...||..|. |.||.|.||||||||       :...|...|.|..||....|.:||..
  Rat   422 AASFSNGPAANAPAYSVQAVGAPGLRHFLYKPLDIPEQHRQLPQFTSPELEAPYSREEERQRLSD 486

  Fly   452 IYCDLLHRIHNSSRPLKLIYEMKEREVVLAWATGTYELYAIFEPVVDKATVIKYVDKLIKWIEKE 516
            :|..|..|:|::||||:|||.:.|:|.:|||.|..:|||....|:|.||..|..|.||::|:.||
  Rat   487 LYHRLHARLHSTSRPLRLIYHVAEKETLLAWVTSKFELYTCLSPLVTKAAAILVVTKLLRWVRKE 551

  Fly   517 YDVYFIR 523
            .|..|||
  Rat   552 EDRLFIR 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mon1	NP_608868.1	Mon1	115..527	CDD:281196	165/425 (39%)
Mon1b	XP_006255736.1	PHA03169	26..>140	CDD:223003	18/89 (20%)
Mon1b	XP_006255736.1	Mon1	144..561	CDD:367367	165/425 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340333
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0997
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54491
OrthoDB	1	1.010	-	-		D265654at33208
OrthoFinder	1	1.000	-	-		FOG0002019
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102023
Panther	1	1.100	-	-	O	PTHR13027
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1326
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.760