DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mon1 and Mon1b

DIOPT Version :9

Sequence 1:	NP_608868.1	Gene:	Mon1 / 33689	FlyBaseID:	FBgn0031640	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_001041608.1	Gene:	Mon1b / 270096	MGIID:	1923231	Length:	553	Species:	Mus musculus

Alignment Length:	542	Identity:	198/542 - (36%)
Similarity:	288/542 - (53%)	Gaps:	51/542 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LDAEGDPESP------NLYQEADPDQEAEQQNHSIISELRDGLGTMRD-------NSALSPEPGQ 70
            ::|.||...|      :|.....|.:||........|.|..|.|...|       :|.|||.|..
Mouse     1 MEAGGDNAVPAPGGVEDLVDTQFPREEAGDSERVHASTLDPGDGDPEDTGSKDQPSSLLSPLPQT 65

  Fly    71 ENKGLAASV-----ESLALSTSTSAKTEDSIGGGLEEEYD---YQHDSLWQGQKKHIFILSEAGK 127
            |    |||.     |:.|.|.|:.....:|...|..|:.|   ...|..|:.|:||:|:||||||
Mouse    66 E----AASSTCEHWETAAASDSSPPGEPESNSEGQGEDPDDGGDPSDEDWRSQRKHVFVLSEAGK 126

  Fly   128 PIFSLHGNEDKLATLFGVIQALVSFVQMGQDAITSIHAGGIKFAFMQRSSLILVAASRSNMSVQQ 192
            ||:|.:|:.:.|:...||:.|||||||...|||.:|:|...|..|:|:..|:|||.||:..|..|
Mouse   127 PIYSRYGSVEALSATMGVMTALVSFVQSAGDAIRAIYAEDHKLVFLQQGPLLLVAVSRTPQSAAQ 191

  Fly   193 LQLQLGDVYNQILSILTYSHMTKIFERRKNFDLRRLLSGSERLFYNLLANDSSSAKVSNNIFTFL 257
            |:.:|..|:.||:|.||.:.:.:||..::|:||||||:||||....||  ||    |..:....|
Mouse   192 LRGELLAVHAQIVSTLTRASVARIFAHKQNYDLRRLLAGSERTLDRLL--DS----VEQDPGALL 250

  Fly   258 TNSIRVFPLPTTIRSQITSAIQSNCSKIKNLVFAVLIANNKLIALVR----MKKYSIHPADLRLI 318
            ..::|..||...:|..:.:.:: .|: ...|..:||....:||.:.:    :.:..:.||||:|:
Mouse   251 LGAVRCVPLARPLRDALGTLLR-RCT-APGLALSVLAVGGRLITVAQERNVLAECRLDPADLQLL 313

  Fly   319 FNLVECSESFKSSENWSPICLPKFDMNGYLHAHVSYLADDCQACLLLLSVDRDAFFTLAEAKAKI 383
            .:.|. :.:|.:.|.|:|:|||:|:.:|:.:|:|:.| |....|||||..:|:||..:|..:..:
Mouse   314 LDWVG-APAFAAGEAWAPVCLPRFNPDGFFYAYVARL-DSMPVCLLLLGTNREAFHAMAACRRLV 376

  Fly   384 TEKLRKSHCL----EAINEELQQPFNAKLYQ-QVVGIPELRHFLYKP-------KSTAQLLCPML 436
            .:.:.....|    ||.|.......:|..|. |.||.|.||||||||       :...|...|.|
Mouse   377 EDGMHNLGALRTLGEAANFSNGPAASAPAYSVQAVGAPGLRHFLYKPLDIPEQHRQLPQFTSPEL 441

  Fly   437 RHPYKSLTELERLEAIYCDLLHRIHNSSRPLKLIYEMKEREVVLAWATGTYELYAIFEPVVDKAT 501
            ..||....|.:||..:|..|..|:|::||||:|||.:.|:|.:|||.|..:|||....|:|.||.
Mouse   442 EAPYSREEERQRLSDLYHRLHARLHSTSRPLRLIYHVAEKETLLAWVTSKFELYTCLSPLVTKAG 506

  Fly   502 VIKYVDKLIKWIEKEYDVYFIR 523
            .|..|.||::|:.||.|..|||
Mouse   507 AILVVTKLLRWVRKEEDRLFIR 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mon1	NP_608868.1	Mon1	115..527	CDD:281196	166/425 (39%)
Mon1b	NP_001041608.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..111		31/113 (27%)
		Mon1	114..531	CDD:281196	166/425 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	534..553
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836633
Domainoid	1	1.000	361	1.000	Domainoid score	I952
eggNOG	1	0.900	-	-		E1_KOG0997
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2143
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54491
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002019
OrthoInspector	1	1.000	-	-		otm42775
orthoMCL	1	0.900	-	-		OOG6_102023
Panther	1	1.100	-	-	O	PTHR13027
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R732
SonicParanoid	1	1.000	-	-		X1326
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790