Protein Alignment Mon1 and MON1B

DIOPT Version :10

• Sequence 1: NP_608868.1
• Gene: Mon1 / 33689
• FlyBaseID: FBgn0031640
• Length: 528
• Species: Drosophila melanogaster
• Sequence 2: NP_055755.1
• Gene: MON1B / 22879
• HGNCID: 25020
• Length: 547
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 188/536 - (35%)
• Similarity: 290/536 - (54%)
• Gaps: 45/536 - (8%)

  Fly    19 LDAEGDPESP------NLYQEADPDQEAEQQN--HSIISELRD-GL---GTMRDNSALSPEPGQE 71
            ::..||..:|      :|.....|.:||.:..  |::..:..| ||   |:...:...||.|..:
Human     1 MEVGGDTAAPAPGGAEDLEDTQFPSEEAREGGGVHAVPPDPEDEGLEETGSKDKDQPPSPSPPPQ 65

  Fly    72 NKGLAASV---ESLALSTSTSAKTEDSIGGGLEEEYDYQHDSLWQGQKKHIFILSEAGKPIFSLH 133
            ::.|:::.   ...|...|.:...|.|.||...:..|.:    |:.|:||:|:||||||||:|.:
Human    66 SEALSSTSRLWSPAAPENSPTCSPESSSGGQGGDPSDEE----WRSQRKHVFVLSEAGKPIYSRY 126

  Fly   134 GNEDKLATLFGVIQALVSFVQMGQDAITSIHAGGIKFAFMQRSSLILVAASRSNMSVQQLQLQLG 198
            |:.:.|:...||:.|||||||...|||.:|:|...|..|:|:..|:|||.||::.|..||:.:|.
Human   127 GSVEALSATMGVMTALVSFVQSAGDAIRAIYAEDHKLVFLQQGPLLLVAMSRTSQSAAQLRGELL 191

  Fly   199 DVYNQILSILTYSHMTKIFERRKNFDLRRLLSGSERLFYNLLANDSSSAKVSNNIFTFLTNSIRV 263
            .|:.||:|.||.:.:.:||..::|:||||||:||||....||  ||    :..:....|..::|.
Human   192 AVHAQIVSTLTRASVARIFAHKQNYDLRRLLAGSERTLDRLL--DS----MEQDPGALLLGAVRC 250

  Fly   264 FPLPTTIRSQITSAIQSNCSKIKNLVFAVLIANNKLIALVR----MKKYSIHPADLRLIFNLVEC 324
            .||...:|..: .|:...|: ...|..:||....:||...:    :.:..:.||||:|:.:.|.
Human   251 VPLARPLRDAL-GALLRRCT-APGLALSVLAVGGRLITAAQERNVLAECRLDPADLQLLLDWVG- 312

  Fly   325 SESFKSSENWSPICLPKFDMNGYLHAHVSYLADDCQACLLLLSVDRDAFFTLAEAKAKITEKLRK 389
            :.:|.:.|.|:|:|||:|:.:|:.:|:|:.| |....|||||...|:||..:|..:..:.:.:..
Human   313 APAFAAGEAWAPVCLPRFNPDGFFYAYVARL-DAMPVCLLLLGTQREAFHAMAACRRLVEDGMHA 376

  Fly   390 SHCLEAINEELQ----QPFNAKLYQ-QVVGIPELRHFLYKP-------KSTAQLLCPMLRHPYKS 442
            ...:.|:.|...    ...:|..|. |.||.|.||||||||       :...|...|.|..||..
Human   377 LGAMRALGEAASFSNASSASAPAYSVQAVGAPGLRHFLYKPLDIPDHHRQLPQFTSPELEAPYSR 441

  Fly   443 LTELERLEAIYCDLLHRIHNSSRPLKLIYEMKEREVVLAWATGTYELYAIFEPVVDKATVIKYVD 507
            ..|.:||..:|..|..|:|::||||:|||.:.|:|.:|||.|..:|||....|:|.||..|..|.
Human   442 EEERQRLSDLYHRLHARLHSTSRPLRLIYHVAEKETLLAWVTSKFELYTCLSPLVTKAGAILVVT 506

  Fly   508 KLIKWIEKEYDVYFIR 523
            ||::|::||.|..|||
Human   507 KLLRWVKKEEDRLFIR 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mon1	NP_608868.1	Fuz_longin_1	117..239	CDD:465953	60/121 (50%)
		Fuz_longin_2	286..385	CDD:465954	33/102 (32%)
		Fuz_longin_3	417..516	CDD:465955	45/105 (43%)
MON1B	NP_055755.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..106		23/108 (21%)
		Fuz_longin_1	110..232	CDD:465953	60/121 (50%)
		Fuz_longin_2	272..370	CDD:465954	33/99 (33%)
		Fuz_longin_3	409..516	CDD:465955	46/106 (43%)