DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mon1 and MON1B

DIOPT Version :9

Sequence 1:	NP_608868.1	Gene:	Mon1 / 33689	FlyBaseID:	FBgn0031640	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_055755.1	Gene:	MON1B / 22879	HGNCID:	25020	Length:	547	Species:	Homo sapiens

Alignment Length:	536	Identity:	188/536 - (35%)
Similarity:	290/536 - (54%)	Gaps:	45/536 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LDAEGDPESP------NLYQEADPDQEAEQQN--HSIISELRD-GL---GTMRDNSALSPEPGQE 71
            ::..||..:|      :|.....|.:||.:..  |::..:..| ||   |:...:...||.|..:
Human     1 MEVGGDTAAPAPGGAEDLEDTQFPSEEAREGGGVHAVPPDPEDEGLEETGSKDKDQPPSPSPPPQ 65

  Fly    72 NKGLAASV---ESLALSTSTSAKTEDSIGGGLEEEYDYQHDSLWQGQKKHIFILSEAGKPIFSLH 133
            ::.|:::.   ...|...|.:...|.|.||...:..|.:    |:.|:||:|:||||||||:|.:
Human    66 SEALSSTSRLWSPAAPENSPTCSPESSSGGQGGDPSDEE----WRSQRKHVFVLSEAGKPIYSRY 126

  Fly   134 GNEDKLATLFGVIQALVSFVQMGQDAITSIHAGGIKFAFMQRSSLILVAASRSNMSVQQLQLQLG 198
            |:.:.|:...||:.|||||||...|||.:|:|...|..|:|:..|:|||.||::.|..||:.:|.
Human   127 GSVEALSATMGVMTALVSFVQSAGDAIRAIYAEDHKLVFLQQGPLLLVAMSRTSQSAAQLRGELL 191

  Fly   199 DVYNQILSILTYSHMTKIFERRKNFDLRRLLSGSERLFYNLLANDSSSAKVSNNIFTFLTNSIRV 263
            .|:.||:|.||.:.:.:||..::|:||||||:||||....||  ||    :..:....|..::|.
Human   192 AVHAQIVSTLTRASVARIFAHKQNYDLRRLLAGSERTLDRLL--DS----MEQDPGALLLGAVRC 250

  Fly   264 FPLPTTIRSQITSAIQSNCSKIKNLVFAVLIANNKLIALVR----MKKYSIHPADLRLIFNLVEC 324
            .||...:|..: .|:...|: ...|..:||....:||...:    :.:..:.||||:|:.:.|.
Human   251 VPLARPLRDAL-GALLRRCT-APGLALSVLAVGGRLITAAQERNVLAECRLDPADLQLLLDWVG- 312

  Fly   325 SESFKSSENWSPICLPKFDMNGYLHAHVSYLADDCQACLLLLSVDRDAFFTLAEAKAKITEKLRK 389
            :.:|.:.|.|:|:|||:|:.:|:.:|:|:.| |....|||||...|:||..:|..:..:.:.:..
Human   313 APAFAAGEAWAPVCLPRFNPDGFFYAYVARL-DAMPVCLLLLGTQREAFHAMAACRRLVEDGMHA 376

  Fly   390 SHCLEAINEELQ----QPFNAKLYQ-QVVGIPELRHFLYKP-------KSTAQLLCPMLRHPYKS 442
            ...:.|:.|...    ...:|..|. |.||.|.||||||||       :...|...|.|..||..
Human   377 LGAMRALGEAASFSNASSASAPAYSVQAVGAPGLRHFLYKPLDIPDHHRQLPQFTSPELEAPYSR 441

  Fly   443 LTELERLEAIYCDLLHRIHNSSRPLKLIYEMKEREVVLAWATGTYELYAIFEPVVDKATVIKYVD 507
            ..|.:||..:|..|..|:|::||||:|||.:.|:|.:|||.|..:|||....|:|.||..|..|.
Human   442 EEERQRLSDLYHRLHARLHSTSRPLRLIYHVAEKETLLAWVTSKFELYTCLSPLVTKAGAILVVT 506

  Fly   508 KLIKWIEKEYDVYFIR 523
            ||::|::||.|..|||
Human   507 KLLRWVKKEEDRLFIR 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mon1	NP_608868.1	Mon1	115..527	CDD:281196	164/425 (39%)
MON1B	NP_055755.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..106		23/108 (21%)
MON1B	NP_055755.1	Mon1	108..525	CDD:281196	164/425 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146532
Domainoid	1	1.000	359	1.000	Domainoid score	I968
eggNOG	1	0.900	-	-		E1_KOG0997
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	361	1.000	Inparanoid score	I2203
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54491
OrthoDB	1	1.010	-	-		D265654at33208
OrthoFinder	1	1.000	-	-		FOG0002019
OrthoInspector	1	1.000	-	-		otm40701
orthoMCL	1	0.900	-	-		OOG6_102023
Panther	1	1.100	-	-	O	PTHR13027
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R732
SonicParanoid	1	1.000	-	-		X1326
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.840