DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mon1 and mon1a

DIOPT Version :9

Sequence 1:	NP_608868.1	Gene:	Mon1 / 33689	FlyBaseID:	FBgn0031640	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_001307360.1	Gene:	mon1a / 100073333	ZFINID:	ZDB-GENE-070615-6	Length:	530	Species:	Danio rerio

Alignment Length:	517	Identity:	193/517 - (37%)
Similarity:	291/517 - (56%)	Gaps:	55/517 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EYLDAEGDPESPNLYQEADPDQ-----EAEQQNHSIISELRDGLGTMRDNSALSPEPGQENKGLA 76
            |.|.|:.:|.:.|...|.|..|     |.:::.|.                    |..||.||
Zfish    64 EDLTADSEPNTDNKSAEVDDAQEEALEEGDEEEHL--------------------ESEQEEKG-- 106

  Fly    77 ASVESLALSTSTSAKTEDSIGGGLEEEYDYQHDSLWQGQKKHIFILSEAGKPIFSLHGNEDKLAT 141
                ...|..|..||.||..            ...|:..:||:|:||||||||::.:|.|:.|::
Zfish   107 ----KEELKNSNKAKEEDVT------------SETWRSHRKHVFVLSEAGKPIYTRYGTEEALSS 155

  Fly   142 LFGVIQALVSFVQMGQDAITSIHAGGIKFAFMQRSSLILVAASRSNMSVQQLQLQLGDVYNQILS 206
            :.||:..|:|||:..::.|.||||.|.:..|::::.||||..||::.|.::|..:|..||.||:|
Zfish   156 IMGVMMLLMSFVEDKKNIIRSIHADGYRVVFLRKTPLILVGVSRTSCSDRELTRELQYVYFQIVS 220

  Fly   207 ILTYSHMTKIFERRKNFDLRRLLSGSERLFYNLLANDSSSAKVSNNIFTFLTNSIRVFPLPTTIR 271
            :||.:.:..:|:.|:::||||||:|||.|..|||       ::.:.....|.:::...||..:.|
Zfish   221 LLTLTQLNHVFQHRQSYDLRRLLAGSEHLTDNLL-------RLLDRDPGLLLSAVMCLPLANSAR 278

  Fly   272 SQITSAIQSNCSKIKNLVFAVLIANNKLIALVRMKKYSIHPADLRLIFNLVECSESFKSSENWSP 336
            ..::|::|:  :|.|||||::|:|.|:|:.|||.|...:|..||.|:||||..|.||:..|.|:|
Zfish   279 DVVSSSLQA--AKAKNLVFSILLAGNRLVTLVRKKDQFLHHMDLHLLFNLVGSSSSFREGEGWTP 341

  Fly   337 ICLPKFDMNGYLHAHVSYLADDCQACLLLLSVDRDAFFTLAEAKAKITEKLRKSHCLEAINEELQ 401
            ||||||:..|:.|||:|||......||:|:|.||:.||.|::.|.:..|:||:....:::.|.|.
Zfish   342 ICLPKFNPAGFFHAHISYLEPASDLCLILVSTDREDFFNLSDCKKRFLERLRRRSAYQSLQEALN 406

  Fly   402 QPFNAKLYQQVVGIPELRHFLYKPKSTAQLLCPMLRHPYKSLTELERLEAIYCDLLHRIHNSSRP 466
            .| :..|.|  |||||||||:||.||:.....|.|...|:...|.|||..:|..|...:|:.:||
Zfish   407 TP-SYSLSQ--VGIPELRHFVYKSKSSGLYTSPDLPALYEGGEEQERLMGLYQHLHSCLHHPTRP 468

  Fly   467 LKLIYEMKEREVVLAWATGTYELYAIFEPVVDKATVIKYVDKLIKWIEKEYDVYFIRNHATF 528
            |:.||...:.|.:.|..|..:|||..|.|:..|:..:..|::|:|||.||.|..||.:..|:
Zfish   469 LRCIYRCTDTENLYALVTSGFELYLCFSPLGTKSLAVSAVNRLLKWIRKEEDRLFILSPLTY 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mon1	NP_608868.1	Mon1	115..527	CDD:281196	170/411 (41%)
mon1a	NP_001307360.1	Mon1	129..529	CDD:281196	170/411 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580160
Domainoid	1	1.000	331	1.000	Domainoid score	I1124
eggNOG	1	0.900	-	-		E1_KOG0997
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7191
Inparanoid	1	1.050	333	1.000	Inparanoid score	I2406
OMA	1	1.010	-	-		QHG54491
OrthoDB	1	1.010	-	-		D265654at33208
OrthoFinder	1	1.000	-	-		FOG0002019
OrthoInspector	1	1.000	-	-		otm25789
orthoMCL	1	0.900	-	-		OOG6_102023
Panther	1	1.100	-	-	LDO	PTHR13027
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R732
SonicParanoid	1	1.000	-	-		X1326
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800