DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12194 and QDR2

DIOPT Version :9

Sequence 1:	NP_001162873.1	Gene:	CG12194 / 33685	FlyBaseID:	FBgn0031636	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_012145.1	Gene:	QDR2 / 854685	SGDID:	S000001383	Length:	542	Species:	Saccharomyces cerevisiae

Alignment Length:	541	Identity:	109/541 - (20%)
Similarity:	188/541 - (34%)	Gaps:	172/541 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VSSSSSSTCSSSD--DEVHPVVR--RRSTRDTELAGHQKDAGCCDP--TSTPH-RF-----LALL 62
            ::.::||....:|  ||:...::  .|.|.| :||..:.::...:|  |:.|| ||     ..|:
Yeast     1 MAGATSSIIRENDFEDELAESMQSYNRETAD-KLALTRTESVKPEPEITAPPHSRFSRSFKTVLI 64

  Fly    63 FMC-LLGFGSYFCYDNPGALQ----DVFQKELQLSSTEFTLIYSIY-SWPNIVLCFVGGFL--ID 119
            ..| ..||.|...    ||:.    .|.:::..:......:...:| .:..:...|:|||.  :.
Yeast    65 AQCAFTGFFSTIA----GAIYYPVLSVIERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLG 125

  Fly   120 RVFGIRLGTIIY--------------MLIVL-------VGQLIFATGGVLGHFWLMIVGRFVFGI 163
            |...:.:..:||              .:|||       :..:|....|::|.    :..|
Yeast   126 RRPVVLVAIVIYFGACIGLACAQTYAQIIVLRCLQAAGISPVIAINSGIMGD----VTTR----- 181

  Fly   164 GAESLAVAQNSYAVLWFKGKEINMVFGLQLSVARFGSTVNFWIMQPLYGYVSKSYSGYKGLGVAL 228
             ||              :|..:..|.|.|:..:.||:         |.|....|..|::  .:..
Yeast   182 -AE--------------RGGYVGYVAGFQVLGSAFGA---------LIGAGLSSRWGWR--AIFW 220

  Fly   229 FLASSTCVMSLVCTLILGWMDKRAERILKRN--------------------------NNPGGELA 267
            |||..:.:..|...|||    ...:|.:..|                          :||..|..
Yeast   221 FLAIGSGICFLASFLIL----PETKRNISGNGSVTPKSYLNRAPILVLPTVRKSLHLDNPDYETL 281

  Fly   268 KLSDIVTFKLDFWMVSV--VCVAYYVAIFPF-------VALGQAFFVSNFHMTPDEANTVNSIVY 323
            :|...:.....|.::..  :|:...||...|       .||..| ....:|:|..:.    .:.|
Yeast   282 ELPTQLNLLAPFKILKAYEICILMLVAGLQFAMYTTHLTALSTA-LSKQYHLTVAKV----GLCY 341

  Fly   324 LISAIASPLFGFVIDKVGRNVTWVFCATI-----------STLL------AHFLLTFTHLDPYIG 371
            |.|.|.: |...||  .||.:.|.:...:           |.||      .:.:......||
Yeast   342 LPSGICT-LCSIVI--AGRYLNWNYRRRLKYYQNWLGKKRSKLLEEHDNDLNLVQRIIENDP--- 400

  Fly   372 MSIMGLSYSMLAASLWP-LVSLIVPEYQLGTAYGFCQSVQNLGLAVVTIAAGIIVDSSGGSHFWL 435
                ..::::..|.|.| .|:|::..... .|||:|.:|: ..||.|...:|           :.
Yeast   401 ----KYTFNIFKARLQPAFVTLLLSSSGF-CAYGWCITVK-APLAAVLCMSG-----------FA 448

  Fly   436 QVF------FMSFLLVSLLAT 450
            .:|      |.:.|:|.|..|
Yeast   449 SLFSNCILTFSTTLIVDLFPT 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12194	NP_001162873.1	MFS	61..454	CDD:119392	93/478 (19%)
CG12194	NP_001162873.1	MFS_1	64..416	CDD:284993	83/433 (19%)
QDR2	NP_012145.1	MFS_Tpo1_MDR_like	64..530	CDD:340881	92/477 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341817
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930