DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12194 and mrva

DIOPT Version :9

Sequence 1:	NP_001162873.1	Gene:	CG12194 / 33685	FlyBaseID:	FBgn0031636	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001261505.1	Gene:	mrva / 38808	FlyBaseID:	FBgn0035763	Length:	478	Species:	Drosophila melanogaster

Alignment Length:	474	Identity:	336/474 - (70%)
Similarity:	401/474 - (84%)	Gaps:	6/474 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSREERKPIVSSSSSSTCSSSDDEVHPVVRRRSTRDTELAGHQKDAGCCDPTSTPHRFLALLFMC 65
            |:||:.:.||.:...|..:..|.    ||.|...||.||:  ....|||.|:||.|||:||:|||
  Fly     1 MAREDEERIVDNEEVSRPTEEDQ----VVSRAGRRDNELS--LPSGGCCMPSSTSHRFMALVFMC 59

  Fly    66 LLGFGSYFCYDNPGALQDVFQKELQLSSTEFTLIYSIYSWPNIVLCFVGGFLIDRVFGIRLGTII 130
            |||||||||||.|||||:.|:|:|.|:|.:||||||||||||:||||||||||||:|||||||||
  Fly    60 LLGFGSYFCYDAPGALQNYFKKDLNLTSAQFTLIYSIYSWPNVVLCFVGGFLIDRLFGIRLGTII 124

  Fly   131 YMLIVLVGQLIFATGGVLGHFWLMIVGRFVFGIGAESLAVAQNSYAVLWFKGKEINMVFGLQLSV 195
            ||:|:||||||||.||:|..||:||:|||:||||||||||||||||||||||||:||||||||||
  Fly   125 YMMILLVGQLIFACGGILDAFWMMILGRFIFGIGAESLAVAQNSYAVLWFKGKELNMVFGLQLSV 189

  Fly   196 ARFGSTVNFWIMQPLYGYVSKSYSGYKGLGVALFLASSTCVMSLVCTLILGWMDKRAERILKRNN 260
            ||||||||||:|||:|.|||..|.|:..|||.|.||:.|||||:.|.||||||||||||||:|||
  Fly   190 ARFGSTVNFWVMQPIYEYVSNFYKGHTALGVVLLLATLTCVMSMTCALILGWMDKRAERILQRNN 254

  Fly   261 NPGGELAKLSDIVTFKLDFWMVSVVCVAYYVAIFPFVALGQAFFVSNFHMTPDEANTVNSIVYLI 325
            ||.|::.||:|:.:||..|||||::|||||||||||:||||.|||..|.::|.|||||:|:||||
  Fly   255 NPAGQIPKLTDVFSFKPPFWMVSIICVAYYVAIFPFIALGQNFFVDRFGLSPAEANTVDSLVYLI 319

  Fly   326 SAIASPLFGFVIDKVGRNVTWVFCATISTLLAHFLLTFTHLDPYIGMSIMGLSYSMLAASLWPLV 390
            :|::||:|||:|||:||||||||.||::|:.||.|||||.|.||:||.|||||||||||||||||
  Fly   320 AAVSSPVFGFIIDKLGRNVTWVFTATLTTIGAHALLTFTQLTPYVGMIIMGLSYSMLAASLWPLV 384

  Fly   391 SLIVPEYQLGTAYGFCQSVQNLGLAVVTIAAGIIVDSSGGSHFWLQVFFMSFLLVSLLATCAIWA 455
            :||:||||||||||||||:|||||||:||.||||||.|||.|.|||:|||.:|.::|::|..|||
  Fly   385 ALIIPEYQLGTAYGFCQSIQNLGLAVITIVAGIIVDHSGGEHMWLQLFFMGWLTIALISTGVIWA 449

  Fly   456 YNRKHQGNLNMSPAQRATY 474
            ||.|::|||||:|.|||.:
  Fly   450 YNNKNRGNLNMTPQQRAQF 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12194	NP_001162873.1	MFS	61..454	CDD:119392	297/392 (76%)
CG12194	NP_001162873.1	MFS_1	64..416	CDD:284993	272/351 (77%)
mrva	NP_001261505.1	MFS	55..448	CDD:119392	297/392 (76%)
mrva	NP_001261505.1	MFS_1	58..410	CDD:284993	272/351 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455386
Domainoid	1	1.000	297	1.000	Domainoid score	I1432
eggNOG	1	0.900	-	-		E2759_KOG4686
Homologene	1	1.000	-	-		H11228
Inparanoid	1	1.050	521	1.000	Inparanoid score	I1221
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53923
OrthoDB	1	1.010	-	-		D412964at33208
OrthoFinder	1	1.000	-	-		FOG0007323
OrthoInspector	1	1.000	-	-		otm25423
orthoMCL	1	0.900	-	-		OOG6_101417
Panther	1	1.100	-	-	P	PTHR23512
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5598
SonicParanoid	1	1.000	-	-		X5435
	14	13.840