DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tank and EI24

DIOPT Version :9

Sequence 1:	NP_608864.1	Gene:	tank / 33684	FlyBaseID:	FBgn0031635	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_004870.3	Gene:	EI24 / 9538	HGNCID:	13276	Length:	340	Species:	Homo sapiens

Alignment Length:	349	Identity:	135/349 - (38%)
Similarity:	197/349 - (56%)	Gaps:	50/349 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AIKNITLGILYGLWDSIRGMTLVLHIDDEVNRQNAEQEHRQQLRRTDKDRYERARRSPSPVPSSA 67
            ::|.....:..|:.|||.|:..:..:|..:.::..||               |.||:     ||.
Human     4 SVKTFLQDLARGIKDSIWGICTISKLDARIQQKREEQ---------------RRRRA-----SSV 48

  Fly    68 AAMIREEYAKQAEENADERTLEKILGKKPAAQDQHPQGEKKIAKKLFKCCMLNGGFTWLSIVLFE 132
            .|..|.:..::.:|:                       |.:|..::|:||..|||..|.|::||.
Human    49 LAQRRAQSIERKQES-----------------------EPRIVSRIFQCCAWNGGVFWFSLLLFY 90

  Fly   133 NALLPTLKFCLTIFYG---AHSETLPVVWGWLHPILSLLFGMMWVLPIFMLSKIVSSLWFADIAN 194
            ...:|.|:.......|   .|.:    ||.||...|:.:|..:||||:|:|||:|:::||.|||:
Human    91 RVFIPVLQSVTARIIGDPSLHGD----VWSWLEFFLTSIFSALWVLPLFVLSKVVNAIWFQDIAD 151

  Fly   195 AAYRVRKGRPQLIPGISKLVADFLFSMVVQMLFLVQSMLVNLVPVKYVGSSLCFVHLCLLYSLYS 259
            .|:.|...:|...|.:||::||.||::::|.|||:|.|.|:|.|:..||..:..:|:.||||||.
Human   152 LAFEVSGRKPHPFPSVSKIIADMLFNLLLQALFLIQGMFVSLFPIHLVGQLVSLLHMSLLYSLYC 216

  Fly   260 FEYKWFNMGWELHRRLTYIEKNWPYFFGFGIPLTVLTNLSSSVIVSSCIFSIFFPLFILSGNEAK 324
            |||:|||.|.|:|:||:.||:||||:||||:||..||.:.||.|:|.|:|||.|||||:|.||||
Human   217 FEYRWFNKGIEMHQRLSNIERNWPYYFGFGLPLAFLTAMQSSYIISGCLFSILFPLFIISANEAK 281

  Fly   325 PIVDTTEVSLRLFSPVVFISNLCF 348
            .........|||||.|||:||..|
Human   282 TPGKAYLFQLRLFSLVVFLSNRLF 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tank	NP_608864.1	EI24	164..296	CDD:284638	67/131 (51%)
EI24	NP_004870.3	EI24	120..254	CDD:311296	68/133 (51%)
EI24	NP_004870.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	319..340
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148280
Domainoid	1	1.000	200	1.000	Domainoid score	I3045
eggNOG	1	0.900	-	-		E1_KOG3966
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3588
Inparanoid	1	1.050	256	1.000	Inparanoid score	I3175
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55407
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005680
OrthoInspector	1	1.000	-	-		oto90172
orthoMCL	1	0.900	-	-		OOG6_104073
Panther	1	1.100	-	-	LDO	PTHR21389
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2509
SonicParanoid	1	1.000	-	-		X4663
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790