DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tank and Ei24

DIOPT Version :9

Sequence 1:	NP_608864.1	Gene:	tank / 33684	FlyBaseID:	FBgn0031635	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_001186423.2	Gene:	Ei24 / 13663	MGIID:	108090	Length:	340	Species:	Mus musculus

Alignment Length:	349	Identity:	130/349 - (37%)
Similarity:	198/349 - (56%)	Gaps:	50/349 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AIKNITLGILYGLWDSIRGMTLVLHIDDEVNRQNAEQEHRQQLRRTDKDRYERARRSPSPVPSSA 67
            ::|.....:..|:.|||.|:..:..:|..:.::..||..|:                       |
Mouse     4 SVKTFLQDLGRGIKDSIWGICTISKLDARIQQKREEQRRRR-----------------------A 45

  Fly    68 AAMIREEYAKQAEENADERTLEKILGKKPAAQDQHPQGEKKIAKKLFKCCMLNGGFTWLSIVLFE 132
            ::::.:                    ::|.:.::..:.|.:|..::|:||..|||..|.|::||.
Mouse    46 SSLLAQ--------------------RRPQSVERKQESEPRIVSRIFQCCAWNGGVFWFSLLLFY 90

  Fly   133 NALLPTLKFCLTIFYG---AHSETLPVVWGWLHPILSLLFGMMWVLPIFMLSKIVSSLWFADIAN 194
            ...:|.|:.......|   .|.:    ||.||...|:.:|..:||||:|:|||:|:::||.|||:
Mouse    91 RVFIPVLQSVTARIIGDPSLHGD----VWSWLEFFLTSIFSALWVLPLFVLSKVVNAIWFQDIAD 151

  Fly   195 AAYRVRKGRPQLIPGISKLVADFLFSMVVQMLFLVQSMLVNLVPVKYVGSSLCFVHLCLLYSLYS 259
            .|:.|...:|...|.:||::||.||::::|.|||:|.|.|:|.|:..||..:..:|:.||||||.
Mouse   152 LAFEVSGRKPHPFPSVSKIIADMLFNLLLQALFLIQGMFVSLFPIHLVGQLVSLLHMSLLYSLYC 216

  Fly   260 FEYKWFNMGWELHRRLTYIEKNWPYFFGFGIPLTVLTNLSSSVIVSSCIFSIFFPLFILSGNEAK 324
            |||:|||.|.|:|:||:.||:||||:||||:||..||.:.||.|:|.|:|||.|||||:|.||||
Mouse   217 FEYRWFNKGIEMHQRLSNIERNWPYYFGFGLPLAFLTAMQSSYIISGCLFSILFPLFIISANEAK 281

  Fly   325 PIVDTTEVSLRLFSPVVFISNLCF 348
            .........|||||.|||:||..|
Mouse   282 TPGKAYLFQLRLFSLVVFLSNRLF 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tank	NP_608864.1	EI24	164..296	CDD:284638	67/131 (51%)
Ei24	NP_001186423.2	Interaction with BH3 domain of BCL2	52..115		17/66 (26%)
		EI24	120..254	CDD:336651	68/133 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	319..340
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838367
Domainoid	1	1.000	200	1.000	Domainoid score	I3044
eggNOG	1	0.900	-	-		E1_KOG3966
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3588
Inparanoid	1	1.050	259	1.000	Inparanoid score	I3119
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55407
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005680
OrthoInspector	1	1.000	-	-		oto93746
orthoMCL	1	0.900	-	-		OOG6_104073
Panther	1	1.100	-	-	LDO	PTHR21389
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2509
SonicParanoid	1	1.000	-	-		X4663
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.830