DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and GLR3.3

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001322169.1	Gene:	GLR3.3 / 840859	AraportID:	AT1G42540	Length:	933	Species:	Arabidopsis thaliana

Alignment Length:	1009	Identity:	202/1009 - (20%)
Similarity:	376/1009 - (37%)	Gaps:	273/1009 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PKTSKILWLLGFLSLLSSFSL----EIAAQTTQNINVL----FINEVDNEPAAKAVEVV--LTYL 60
            ||..||..:..|.|::...:.    |.......|.::|    |...:.|...:..:.:|  |.::
plant    26 PKVVKIGSIFSFDSVIGKVAKIAIDEAVKDVNSNPDILSGTKFSVSMQNSNCSGFMGMVEALRFM 90

  Fly    61 KKNI------RYGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETV 119
            :|:|      :..:...:.|..||:....:|..|:.:...:.:   |.|:.|..|.......:.:
plant    91 EKDIVGIIGPQCSVVAHMISHMANELRVPLLSFAVTDPVMSPL---QFPYFIRTTQSDLYQMDAI 152

  Fly   120 KSFTQALGLPTISA-----SYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPE-AIRSIVIHMNI 178
            .|.....|...:.|     .:|:.|...    |::......|::...|.:.|: |:....| ||:
plant   153 ASIVDFYGWKEVIAVFVDDDFGRNGVAA----LNDKLASRRLRITYKAGLHPDTAVNKNEI-MNM 212

  Fly   179 TNAAILYDDSFVMDH-------------KYKSLLQN----IQTRHVITAIAKDGKREREEQIEKL 226
            ....:|.....|:.|             ||..::.|    |.|..:.|.:........|.
plant   213 LIKIMLLQPRIVVIHVYSELGFAVFKEAKYLGMMGNGYVWIATDWLSTNLDSSSPLPAER----- 272

  Fly   227 RNLDINNFFILGTLQSIRMVLESVKPAYFERNF--AWHAITQNEGEISSQ--------------- 274
                      |.|:|.:.::......:.|:|.|  .|..::.....:::.
plant   273 ----------LETIQGVLVLRPHTPDSDFKREFFKRWRKMSGASLALNTYGLYAYDSVMLLARGL 327

  Fly   275 ----RDNATIMFMKPMAYTQYRDRLGLLRTTYNLNEEPQLSSAFYFD---LALRSFLTIKEMLQS 332
                :|...|.|..       ...|..|..:.|||    |.:...||   ..|:..|..:.:..:
plant   328 DKFFKDGGNISFSN-------HSMLNTLGKSGNLN----LEAMTVFDGGEALLKDILGTRMVGLT 381

  Fly   333 GAWPKDMEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDI 397
            |    .:::          ||.|:.         |.|    .:|:                   |
plant   382 G----QLQF----------TPDRSR---------TRP----AYDI-------------------I 400

  Fly   398 NVLQIRGGSSVNSKSIGKWI--SGLNS---ELIVKDEE-------QMKNL--TADTVYR----IF 444
            ||    .|:.|  :.||.|.  |||::   ||:...|:       ::|::  ..:|..:    :|
plant   401 NV----AGTGV--RQIGYWSNHSGLSTVLPELLYTKEKPNMSTSPKLKHVIWPGETFTKPRGWVF 459

  Fly   445 T-------------VVQAPFIMRDETAPKGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDE 496
            :             |....|:.:.......:||:|||:..  ||:....|.: .|:...:||..|
plant   460 SNNGKELKIGVPLRVSYKEFVSQIRGTENMFKGFCIDVFT--AAVNLLPYAV-PVKFIPYGNGKE 521

  Fly   497 NGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPSSLFKFLTVL 561
            |..:..:|:.:.....|..:|.::::..|..::|||.| |...|:.::.......|..:.||...
plant   522 NPSYTHMVEMITTGNFDGVVGDVAIVTNRTKIVDFTQP-YAASGLVVVAPFKKLNSGAWAFLRPF 585

  Fly   562 ETNVWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKEC---LWFCMTSLTPQ 623
            ...:|......:.|...::||.:             ::.::|.|....::|   |||..:::. .
plant   586 NRLMWAVTGCCFLFVGIVVWILE-------------HRTNDEFRGPPKRQCVTILWFSFSTMF-F 636

  Fly   624 GGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQ-----YKILY 683
            ...|...:..||||...|.....||.:||||:|.:.|||.:|.:|::.::.|.::     |::
plant   637 AHRENTVSTLGRLVLIIWLFVVLIINSSYTASLTSILTVQQLSSPIKGIESLRERDDPIGYQV-- 699

  Fly   684 APLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAK 748
                ||.|.:|.....||.:                    |:|
plant   700 ----GSFAESYLRNELNISE--------------------SRL---------------------- 718

  Fly   749 LPATLDEAVAR-VRNSTAATGFAFLGDATDIRYLQL---TNCDLQVVGEEFSRKPYAIAVQQGSH 809
            :|....||.|: :::..:..|.|.:.|  :..|::|   :||..::||:||::..:..|..:.|.
plant   719 VPLGTPEAYAKALKDGPSKGGVAAIVD--ERPYVELFLSSNCAYRIVGQEFTKSGWGFAFPRDSP 781

  Fly   810 LKDQFNNAILTLLNKRQLEKLKEKW-WKNDEALAKCDKPEDQSDGISIQNIGGVFIVIFVGIGMA 873
            |....:.|||.|.....|:::.:|| .||...|   :..|.:||.:.:::..|:|::    .|:|
plant   782 LAIDLSTAILELAENGDLQRIHDKWLMKNACTL---ENAELESDRLHLKSFWGLFLI----CGVA 839

  Fly   874 CITLVFEYWWYRYR---KNPRIIDVAEANAERSN 904
            |:..:|.|:....|   |.|  .|.|.|..::.|
plant   840 CLLALFLYFVQIIRQLYKKP--TDDAIARDQQQN 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	78/445 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	93/427 (22%)
		Lig_chan	565..870	CDD:278489	71/317 (22%)
GLR3.3	NP_001322169.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910