DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and GLR3.4

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001030971.1	Gene:	GLR3.4 / 839268	AraportID:	AT1G05200	Length:	959	Species:	Arabidopsis thaliana

Alignment Length:	1031	Identity:	208/1031 - (20%)
Similarity:	378/1031 - (36%)	Gaps:	313/1031 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SSFSLEIAAQTTQNINVLFINEVDN------EPAAKAV-------EVVLTYLKKNIRYGLSVQLD 73
            ||.||....|...::||..:...|:      :||.||.       :.||..:|.||     :..|
plant    47 SSSSLRPLRQRPSSVNVGALFTYDSFIGRAAKPAVKAAMDDVNADQSVLKGIKLNI-----IFQD 106

  Fly    74 SIEANKSDAKVLLEAICNKYATSI--EKKQTPHLI--------LDTTKSGIASETVKSFTQALGL 128
            |..:........|:.:.||...:|  :.....|:|        :.....|....|:.|......|
plant   107 SNCSGFIGTMGALQLMENKVVAAIGPQSSGIAHMISYVANELHVPLLSFGATDPTLSSLQFPYFL 171

  Fly   129 PTISASYGQQGDLRQ------WRDL------DE-------------AKQK----YLLQVMPPADI 164
            .|....|.|...:..      ||.:      ||             ||::    |...:.|.||
plant   172 RTTQNDYFQMHAIADFLSYSGWRQVIAIFVDDECGRNGISVLGDVLAKKRSRISYKAAITPGAD- 235

  Fly   165 IPEAIRSIVIHMNITNAAILY-----DDSFVMDHKYKSLLQN------IQTRHVITAIAKDGKRE 218
             ..:||.:::.:|:..:.:..     |....:....|||...      |.|..:.||
plant   236 -SSSIRDLLVSVNLMESRVFVVHVNPDSGLNVFSVAKSLGMMASGYVWIATDWLPTA-------- 291

  Fly   219 REEQIEKLRNLDINNFFILGTLQSIR--MVLESVKPAYFERNFAWHAITQNEGEISSQRDNATIM 281
                ::.:.::|.:...:|..:.:.|  .:..|||..:..|   |..:..|:|
plant   292 ----MDSMEHVDSDTMDLLQGVVAFRHYTIESSVKRQFMAR---WKNLRPNDG------------ 337

  Fly   282 FMKPMAYTQYRDRLGLLRTTYNLNEEPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDD 346
                                :|       |.|.|   |..|...:...|       |:.:...::
plant   338 --------------------FN-------SYAMY---AYDSVWLVARAL-------DVFFRENNN 365

  Fly   347 FQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFN-GHSFMK---------------FEM 395
            ....|.|  ||          ..|:..|..|...|.  || |..|||               |:.
plant   366 ITFSNDP--NL----------HKTNGSTIQLSALSV--FNEGEKFMKIILGMNHTGVTGPIQFDS 416

  Fly   396 DIN-------VLQIRGGSSVNSKSIGKWI--SGLNSELIVKDE-------------EQMKNLTAD 438
            |.|       ||.:.|.:   .:::|.|.  |||:   :|..|             :::|.:
plant   417 DRNRVNPAYEVLNLEGTA---PRTVGYWSNHSGLS---VVHPETLYSRPPNTSTANQRLKGI--- 472

  Fly   439 TVYR----------IF-------------TVVQAPFIMRDETAPKGYKGYCIDLINEIAAIVHFD 480
             :|.          :|             .|....::.:|:. |.|.:|||||:..  |||....
plant   473 -IYPGEVTKPPRGWVFPNNGKPLRIGVPNRVSYTDYVSKDKN-PPGVRGYCIDVFE--AAIELLP 533

  Fly   481 YTIQEV----EDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYD--LV 539
            |.:...    .|||     .|..::.:|.:::....|:.:|.::::..|...:|||.|:.:  ||
plant   534 YPVPRTYILYGDGK-----RNPSYDNLVNEVVADNFDVAVGDITIVTNRTRYVDFTQPFIESGLV 593

  Fly   540 GITIMMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEK 604
            .:..:.:..|||.|..|..|:   .:|......:.|...::||.:      ::.|:| ::....:
plant   594 VVAPVKEAKSSPWSFLKPFTI---EMWAVTGGFFLFVGAMVWILE------HRFNQE-FRGPPRR 648

  Fly   605 REFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPV 669
            :   |....||..:::..........:| ||.|...|.....||.:||||:|.:.||:.:|.:.:
plant   649 Q---LITIFWFSFSTMFFSHRENTVSSL-GRFVLIIWLFVVLIINSSYTASLTSILTIRQLTSRI 709

  Fly   670 ESLDDLAKQYKILYAPL---NGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDY 731
            |.:|.|....:    |:   :|:.|..|.....||..                    |::.
plant   710 EGIDSLVTSNE----PIGVQDGTFARNYLINELNILP--------------------SRIV---- 746

  Fly   732 PVSDKYTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRYLQL----TNCDLQVVG 792
            |:.|:                 ::.::.::....|.|.|.:.|  ::.|:::    :||..:.||
plant   747 PLKDE-----------------EQYLSALQRGPNAGGVAAIVD--ELPYIEVLLTNSNCKFRTVG 792

  Fly   793 EEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKW--WKNDEALAKCDKPEDQSDGIS 855
            :||:|..:..|.|:.|.|....:.|||.|..:.:|||:..||  :|::.::...:..:.|   :|
plant   793 QEFTRTGWGFAFQRDSPLAVDMSTAILQLSEEGELEKIHRKWLNYKHECSMQISNSEDSQ---LS 854

  Fly   856 IQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRIIDVAEANAERSNAADHPGK 911
            :::..|:|::    .|:.|...:..::|..:.:..|::. ..|:.||:.....|.:
plant   855 LKSFWGLFLI----CGITCFMALTVFFWRVFWQYQRLLP-ESADEERAGEVSEPSR 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	89/475 (19%)
		PBP2_iGluR_putative	438..836	CDD:270435	96/435 (22%)
		Lig_chan	565..870	CDD:278489	66/313 (21%)
GLR3.4	NP_001030971.1	PBP1_GABAb_receptor_plant	62..450	CDD:380645	91/478 (19%)
		Periplasmic_Binding_Protein_Type_2	<518..591	CDD:389745	21/79 (27%)
		Lig_chan	615..869	CDD:365843	67/318 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1556
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.960