DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and GLR2.1

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_198062.2	Gene:	GLR2.1 / 832768	AraportID:	AT5G27100	Length:	901	Species:	Arabidopsis thaliana

Alignment Length:	1034	Identity:	202/1034 - (19%)
Similarity:	360/1034 - (34%)	Gaps:	283/1034 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MNPKTSKILWLLGFLSLLSSFSLEI--AAQTTQNINVLFINEV--------------------DN 46
            |..:.:.:|.||.|:.:   |.:::  |.....|:||..:|::                    .:
plant     1 MKRENNLVLSLLFFVIV---FLMQVGEAQNRITNVNVGIVNDIGTAYSNMTLLCINMSLSDFYSS 62

  Fly    47 EPAAKAVEVVLTYLKKNIRYGLSVQLDSIEANKSDAKVLLEAICNKYATSI-------------- 97
            .|..:...|......||         |.:.|    |...|:.|.||...:|
plant    63 HPETQTRLVTTVVDSKN---------DVVTA----AAAALDLITNKEVKAILGPWTSMQAQFMIE 114

  Fly    98 --EKKQTPHLILDTTKSGIASETVKSFTQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMP 160
              :|.|.|.:....|...:||...:.|        ..|:|            |::.|.:
plant   115 MGQKSQVPIVTYSATSPSLASIRSQYF--------FRATY------------DDSSQVH------ 153

  Fly   161 PADIIPEAIRSIVIHMNITNAAILY-DDSF---VMDHKYKSLLQNIQTRHVITAIAKDGKREREE 221
                   ||:.|:........|.:| ||:|   :|. :...:||.|..|.....:......:.|.
plant   154 -------AIKEIIKLFGWREVAPVYVDDTFGEGIMP-RLTDVLQEINVRIPYRTVISPNATDDEI 210

  Fly   222 QIEKLRNLDI-NNFFI--LGTLQSIRMVLESVKPAYFERNFAW---HAIT-----QNEGEISSQR 275
            .:|.||.:.: ...|:  |..|.:.|...::.:....::.:.|   :.||     .||.||.:.:
plant   211 SVELLRMMTLPTRVFVVHLVELLASRFFAKATEIGLMKQGYVWILTNTITDVLSIMNETEIETMQ 275

  Fly   276 DNATIMFMKPMA--YTQYRDRLGLLRTTYNLNEEPQLSSAFYFDLALRSFLTIKEMLQSGAWPKD 338
            ....:....|.:  ...:|.|........:||    :...:.:|......|.|:|     |...:
plant   276 GVLGVKTYVPRSKELENFRSRWTKRFPISDLN----VYGLWAYDATTALALAIEE-----AGTSN 331

  Fly   339 MEYL------NCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDI 397
            :.::      |..:.||       |.:..|..|:.:..|...|..:....|..||      |:..
plant   332 LTFVKMDAKRNVSELQG-------LGVSQYGPKLLQTLSRVRFQGLAGDFQFING------ELQP 383

  Fly   398 NVLQIRGGSSVNSKSIGKWISGLNSELIVKDEEQMKNL----TADTVYRIFTVVQAPFIMRDET- 457
            :|.:|...:....::||.|         :|:....||:    .:.|.:..:.....|.|...:|
plant   384 SVFEIVNVNGQGGRTIGFW---------MKEYGLFKNVDQKPASKTTFSSWQDRLRPIIWPGDTT 439

  Fly   458 -APKG------------------------------------YKGYCIDLINEIAAIVHFD--YTI 483
             .|||                                    :.|:.||....:...:.:|  |..
plant   440 SVPKGWEIPTNGKRLQIGVPVNNTFQQFVKATRDPITNSTIFSGFSIDYFEAVIQAIPYDISYDF 504

  Fly   484 QEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDL-VGITIMMQR 547
            ...:||.:         :.:|.::...:.|..:...::.:.|.:.:||::||... ||:.:.::.
plant   505 IPFQDGGY---------DALVYQVYLGKYDAVVADTTISSNRSMYVDFSLPYTPSGVGLVVPVKD 560

  Fly   548 PSSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFD-RWSPYSYQNNREKYKDDEEKREFNLKE 611
            ....||.. ||..|...:||..|.::|....::|:.: |.:|           |.:...::.|..
plant   561 SVRRSSTI-FLMPLTLALWLISLLSFFIIGLVVWVLEHRVNP-----------DFDGPGQYQLST 613

  Fly   612 CLWFCMTSLTPQGGGEAPKN--LS--GRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESL 672
            ..||..:.:.     .||:.  ||  .|:|...|:....::..||||:||:.||...|...|.::
plant   614 IFWFSFSIMV-----FAPRERVLSFWARVVVIIWYFLVLVLTQSYTASLASLLTTQHLHPTVTNI 673

  Fly   673 DD-LAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPV-SD 735
            :. |||...:.|                   |..:.:.:   |.||  ....:.|..:..|. .|
plant   674 NSLLAKGESVGY-------------------QSSFILGR---LRDS--GFSEASLVSYGSPEHCD 714

  Fly   736 KYTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPY 800
            ......||  |..:.|.|.| |..||        .|||        |..| ..::|...|.....
plant   715 ALLSKGQA--EGGVSAVLME-VPYVR--------IFLG--------QYCN-KYKMVQTPFKVDGL 759

  Fly   801 AIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKN-DEALAKCDKP---EDQSDGISIQNIG- 860
            ......||.|....:.|||.:....:..:|:..|:|. ||:   |..|   .|.:..:|.:.:|
plant   760 GFVFPIGSPLVADISRAILKVEESNKANQLENAWFKPIDES---CPDPLTNPDPNPSVSFRQLGF 821

  Fly   861 GVFIVIFVGIGMACITLVFEYWWYRYRKNP-----RIIDVAEANAERSNAADHPGKLVD 914
            ..|.|:|:...:.|...:.::.:...::||     |::      .|:.|..|....:.|
plant   822 DSFWVLFLVAAIVCTMALLKFVYQFLKENPNQRNLRVL------WEKFNEPDQKSYIKD 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	79/444 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	91/445 (20%)
		Lig_chan	565..870	CDD:278489	74/316 (23%)
GLR2.1	NP_198062.2	PBP1_GABAb_receptor	49..411	CDD:107361	79/439 (18%)
		ANF_receptor	49..392	CDD:279440	75/411 (18%)
		GluR_Plant	452..794	CDD:270404	83/411 (20%)
		Periplasmic_Binding_Protein_Type_2	478..>685	CDD:304360	52/232 (22%)
		Lig_chan	576..835	CDD:278489	74/321 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910