DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and GLR2.6

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001330285.1	Gene:	GLR2.6 / 830988	AraportID:	AT5G11180	Length:	967	Species:	Arabidopsis thaliana

Alignment Length:	1000	Identity:	197/1000 - (19%)
Similarity:	358/1000 - (35%)	Gaps:	226/1000 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MILMNPKTSKI--LWLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKK- 62
            |.|.|...|:.  ||||.|::.|  ..|..:.|....:.|..:.:.:...||.::..:...|.:
plant     1 MSLFNHLLSRALPLWLLFFINFL--VLLGKSQQEVLQVQVGIVLDTNATLAALSLRAINMSLSEF 63

  Fly    63 -NIRYGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKSFTQAL 126
             |...|...:   |..|..|:|..:..........|:|::...:|      |..:.....|...|
plant    64 YNTHNGFKTR---IVLNIRDSKRTVVGAAASALYLIKKREVVAII------GPGNSMQAPFLINL 119

  Fly   127 G----LPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDD 187
            |    :|.||.|....       .||..:..|.::..........||.:|:..........:|.|
plant   120 GNQSQVPIISFSASSP-------VLDSLRSPYFIRATHDDSSQVHAISAIIESFRWREVVPIYAD 177

  Fly   188 S--------FVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSIR 244
            :        :::| .::.:...|:.|..|:..:.|...::|  :.||..:. ...||:..|..:.
plant   178 NEFGEGILPYLVD-AFQEINVRIRYRSAISVHSTDDLVKKE--LYKLMTMP-TRVFIVHMLPDLG 238

  Fly   245 MVLESV--KPAYFERNFAWHAITQNEGEISSQRDNATIMFM-------------KPMAY--TQYR 292
            ..|.|:  :.....:.:.| .:|....:..|....:::..|             |.:.|  |::|
plant   239 SRLFSIAKEIGMMTKGYVW-IVTNGIADQMSVMGESSLENMHGVLGVKTYFSRSKELMYLETRWR 302

  Fly   293 DRLGLLRTTYNLNEEPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNTPQRN- 356
            .|.|        .||......:.:|.|....::|:|:..:         :|....|......|:
plant   303 KRFG--------GEELNNFECWGYDTATALAMSIEEISSN---------VNMSFSQTKRNTSRDD 350

  Fly   357 --LDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRGGSSVN-----SKSIG 414
              .||.|....::.|..     |...:|..|.|.: .:|::....|:......||     .:::|
plant   351 TGTDLDDLSFALSGPKL-----LQALATVSFKGVA-GRFQLKNGKLEATTFKIVNIEESGERTVG 409

  Fly   415 KWIS--GLNSELIVKDEEQMKNLTADTVYRIFTVVQAPFIMRDET--APKGYK------------ 463
            .|.|  ||...|.|   .|.....:.:.:|:     .|.|...:|  .|||::
plant   410 FWKSKVGLVKSLRV---NQTGIKISHSSHRL-----RPIIWPGDTIFVPKGWEFPTNAKKLRIAV 466

  Fly   464 ------------------------GYCIDL----INEIAAIVHFDYTIQEVEDGKFGNMDENGQW 500
                                    |:|||:    :.::...|.::|...|..|||     ..|.:
plant   467 PKKDGFNNFVEVTKDANTNAPTITGFCIDVFDTAMRQMPYAVPYEYIPFETPDGK-----PRGSY 526

  Fly   501 NGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPSSLFKFLTVLETNV 565
            :.:|..:...:.|..:|..:::|.|...:||.:||.:...:.::..:.......:.||..|...:
plant   527 DEMVYHVFLGEFDGAVGDTTILANRSTYVDFALPYSETGIVVVVPVKDEREKGKWVFLKPLTREL 591

  Fly   566 WLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLWFCMTSL-----TPQGG 625
            |....|::.:...::|||:      ||.:.:..|.....:..|:   .:|..::|     .|.
plant   592 WFLTAASFLYIGIMVWIFE------YQASGDFRKQSIINKISNV---FYFSFSTLFFAHMRPS-- 645

  Fly   626 GEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQ-YKILYAPLNGS 689
                :::..|::...|.....|:..||||.|.:.|||..|...|..:|||... ..|.|.  .||
plant   646 ----ESIFTRVLVVVWCFVLLILTQSYTATLTSMLTVQELRPTVRHMDDLRNSGVNIGYQ--TGS 704

  Fly   690 SAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATLD 754
            ..   |||   ::||.|               :.|:|..:|.|         |.|.|..|.
plant   705 FT---FER---LKQMGY---------------KESRLKTYDTP---------QEMHELFLK---- 735

  Fly   755 EAVARVRNSTAATGFAFLGDATDIRYLQL---TNCD-LQVVGEEFSRKPYAIAVQQGSHLKDQFN 815
                  ::|......||    .::.|::|   ..|. ..::...|....:..|...||.|....:
plant   736 ------KSSNGGIDAAF----DEVAYVKLFMAKYCSKYTIIEPTFKADGFGFAFPLGSPLVPDLS 790

  Fly   816 NAILTLLNKRQLEKLKEKWWKNDEALAKC--DKPEDQSDGISIQNIGGVFIVIFVGIGMACITLV 878
            ..||.:.....::.::.||...::   .|  ....|....:...:...:|.::||   ::.:.|:
plant   791 RQILNITEGETMKAIENKWLLGEK---HCLDSTTSDSPIRLDHHSFEALFTIVFV---VSMLLLL 849

  Fly   879 FEYWWYRYRKNPRIIDVAEANAERS 903
            ......|||:..:   ..|.||..|
plant   850 AMLVCRRYRQESK---SGEINANNS 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	78/426 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	91/449 (20%)
		Lig_chan	565..870	CDD:278489	66/316 (21%)
GLR2.6	NP_001330285.1	PBP1_GABAb_receptor_plant	38..421	CDD:380645	78/426 (18%)
		GluR_Plant	460..810	CDD:270404	83/415 (20%)
		Lig_chan	590..842	CDD:365843	64/315 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.910