DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and GLUR2

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001320141.1	Gene:	GLUR2 / 829682	AraportID:	AT4G35290	Length:	912	Species:	Arabidopsis thaliana

Alignment Length:	1093	Identity:	206/1093 - (18%)
Similarity:	380/1093 - (34%)	Gaps:	346/1093 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ILWLLGFLSLLSS-------------------FSLEIAAQTTQNINVLFINE-VDNEPA--AKAV 53
            :|.||.|:.|:..                   |||........||.:....| |:::|:  ..:.
plant     4 VLVLLSFIVLIGDGMISEGAGLRPRYVDVGAIFSLGTLQGEVTNIAMKAAEEDVNSDPSFLGGSK 68

  Fly    54 EVVLTYLKKNIRYGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASET 118
            ..:.||..|  |.|....:.:::..::||..::..     .|||......||      :...|..
plant    69 LRITTYDAK--RNGFLTIMGALQFMETDAVAIIGP-----QTSIMAHVLSHL------ANELSVP 120

  Fly   119 VKSFTQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAI 183
            :.||| ||. |::||                .:..:.:|..|....:..||..::.:...:....
plant   121 MLSFT-ALD-PSLSA----------------LQFPFFVQTAPSDLFLMRAIAEMISYYGWSEVIA 167

  Fly   184 LYDDSFVMDHKYKSLLQNIQTRHVITAIAKD---------------------GKREREEQIEKLR 227
            ||:|             :..:|:.|||:..:                     ..||...::.|::
plant   168 LYND-------------DDNSRNGITALGDELEGRRCKISYKAVLPLDVVITSPREIINELVKIQ 219

  Fly   228 NLD-----INNFFILGTLQSIRMVLESVKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMA 287
            .::     :|.|...|.    ::..|:.|....|:.:.|.|.|.    ::|..|
plant   220 GMESRVIIVNTFPKTGK----KIFEEAQKLGMMEKGYVWIATTW----LTSLLD----------- 265

  Fly   288 YTQYRDRLGLLRTTYNLNEEPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNT 352
                           ::|..|..::.     :||..||::.                      :|
plant   266 ---------------SVNPLPAKTAE-----SLRGVLTLRI----------------------HT 288

  Fly   353 P--QRNLDLRDYFTKITEPT---------SYGTFDLVTQSTQP-FNGHSFMKFEMDINVLQIRGG 405
            |  ::..|....:.|::..|         :|.|..::.::.:. .:..:.:.|..|..:..::||
plant   289 PNSKKKKDFVARWNKLSNGTVGLNVYGLYAYDTVWIIARAVKRLLDSRANISFSSDPKLTSMKGG 353

  Fly   406 SSVN---------------------------------------------------SKSIGKWI-- 417
            .|:|                                                   .:.||.|.
plant   354 GSLNLGALSIFDQGSQFLDYIVNTNMTGVTGQIQFLPDRSMIQPSYDIINVVDDGFRQIGYWSNH 418

  Fly   418 SGLNSELIVKDEEQMKNL------------------TADT----VY-------RIFTVVQA---P 450
            |||:   |:..|...|.|                  |::|    |:       ||....:|   .
plant   419 SGLS---IIPPESLYKKLSNRSSSNQHLNNVTWPGGTSETPRGWVFPNNGRRLRIGVPDRASFKE 480

  Fly   451 FIMRDETAPKGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIG 515
            |:.|.:.:.| .:||.||:..  ||:....|.:.. |...||:..:|..:|..|..:.....|..
plant   481 FVSRLDGSNK-VQGYAIDVFE--AAVKLISYPVPH-EFVLFGDGLKNPNFNEFVNNVTIGVFDAV 541

  Fly   516 LGSMSVMAEREIVIDFTVPYYD--LVGITIMMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSF 578
            :|.::::.:|..::|||.||.:  ||.:..:.:...:|   :.||......:|....|.:.....
plant   542 VGDIAIVTKRTRIVDFTQPYIESGLVVVAPVTKLNDTP---WAFLRPFTPPMWAVTAAFFLIVGS 603

  Fly   579 LMWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWL 643
            ::||.:       ....::::....|:   :...|||..:::...........| ||.|...|..
plant   604 VIWILE-------HRINDEFRGPPRKQ---IVTILWFSFSTMFFSHRENTVSTL-GRAVLLIWLF 657

  Fly   644 FGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEI 708
            ...||.:||||:|.:.|||.:|::|:..:|.|.           .||....|:..|..|....:
plant   658 VVLIITSSYTASLTSILTVQQLNSPIRGVDTLI-----------SSSGRVGFQVGSYAENYMID- 710

  Fly   709 WKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLG 773
                .||     :.||:|.....|                     .|..|.::|.|.|   |.:.
plant   711 ----ELN-----IARSRLVPLGSP---------------------KEYAAALQNGTVA---AIVD 742

  Fly   774 DATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKND 838
            :...:.......|...:.|:||:|..:..|..:.|.|....:.|||.|....||:|:.:||...
plant   743 ERPYVDLFLSEFCGFAIRGQEFTRSGWGFAFPRDSPLAIDMSTAILGLSETGQLQKIHDKWLSR- 806

  Fly   839 EALAKCDK-----PEDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYW------WYRYRKNPRI 892
               :.|..     .::.|:.:.:::..|:|:|    .|::|...:|.|:      ::|:.|....
plant   807 ---SNCSNLNGSVSDEDSEQLKLRSFWGLFLV----CGISCFIALFIYFFKIVRDFFRHGKYDEE 864

  Fly   893 IDVAEANAERSNAADHPGKLVDGVILGHSGEKFEKSKAALRPRFNQYPATFKP 945
            ..|....:.||.:..        ..|.:..||.::||..::.:.|. ..:.||
plant   865 ATVPSPESSRSKSLQ--------TFLAYFDEKEDESKRRMKRKRND-DLSLKP 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	74/479 (15%)
		PBP2_iGluR_putative	438..836	CDD:270435	95/413 (23%)
		Lig_chan	565..870	CDD:278489	66/309 (21%)
GLUR2	NP_001320141.1	PBP1_GABAb_receptor_plant	31..422	CDD:380645	78/495 (16%)
		GluR_Plant	466..804	CDD:270404	92/400 (23%)
		Lig_chan	590..840	CDD:395014	67/313 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910