DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and GLR2.4

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001328410.1	Gene:	GLR2.4 / 829299	AraportID:	AT4G31710	Length:	912	Species:	Arabidopsis thaliana

Alignment Length:	962	Identity:	176/962 - (18%)
Similarity:	333/962 - (34%)	Gaps:	289/962 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 TTQNINVLFINE-----VDNEPAAKAVEVVLTYL--KKNIRYGLSVQLDSIEANKSDAKVLLEAI 89
            |..|:::|.||.     ..:.|.:: ..::|.:.  :.::....:..||.|: || :.|.:|...
plant    66 TASNLSLLAINMSLSDFYSSRPESR-TRLLLNFADSRDDVVGAAAAALDLIK-NK-EVKAILGPR 127

  Fly    90 CNKYATSI----EKKQTPHLILDTTKSGIAS--------ETVKSFTQALGLPTISASYGQQGDLR 142
            ....|:.:    :|.|.|.:....|...:.|        .|....:|...:..|...:|
plant   128 TTMQASFVIEVGQKSQVPIISFSATSPFLDSGRSPYFFRSTYDDSSQVQAISEIIKVFG------ 186

  Fly   143 QWRDLDEAKQKYLL--QVMPPADIIPEAIRSI--------VIHMNITNAAILYDDSFVMDHKYKS 197
             ||::....:....  .:||.   :.:|:::|        ||..|.|      ||...:|
plant   187 -WREVVPVYENNAFGEGIMPG---LTDALQAINIRIPYRTVISPNAT------DDEISVD----- 236

  Fly   198 LLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSIRMVLESVKPAYFERNFAW- 261
             |..:.|:.....:                 :.:|.|.      :.|:..::.:....::.:||
plant   237 -LLKLMTKPTRVFV-----------------VHMNRFL------ASRVFSKARETGLMKQGYAWI 277

  Fly   262 -------HAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGL--LRTTYNLNEEPQ-----LSS 312
                   |.:..|..:|.:.:                    |:  :||.:.::||.|     |:.
plant   278 LTNGVIDHLVLMNGTDIEAMQ--------------------GVIGIRTHFPISEELQTFRSRLAK 322

  Fly   313 AF-----------YFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNTPQRNLDLRDYFTKI 366
            ||           .:|......:.::|...:......|:..|..|.:.       |.:.:|..|:
plant   323 AFPVSELNIYGLRAYDATTALAMAVEEAGTTNLTFSKMDGRNISDLEA-------LSVSEYGPKL 380

  Fly   367 TEPTSYGTFDLVTQSTQPFNG--HSFMKFEMDINVLQIRGG-------------------SSVNS 410
            ....|...|..::......:|  |:.: ||: :||  |.||                   ||..:
plant   381 IRSLSQIQFKGLSGDYHFVDGQLHASV-FEI-VNV--IDGGGILVGFWTQDKGLVKDLSPSSGTT 441

  Fly   411 KSIGKWISGLNS--------------ELIVKDEEQMKNLTADTVYRIFTVVQAPFIMRDETAPKG 461
            ::...|.:.||.              |:....:|....:...|..:...|...|  :..||.
plant   442 RTFSSWKNHLNPILWPGITLTVPKGWEIPTNGKELQIGVPVGTFPQFVKVTTDP--LTHETI--- 501

  Fly   462 YKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAERE 526
            ..|:|||....:...:.:|.:.:.:..|     |::|:.|                ..:::|.|.
plant   502 VTGFCIDFFEAVIQAMPYDVSHRFIPFG-----DDDGKTN----------------DTTILANRS 545

  Fly   527 IVIDFTVPYYDL-VGITIMMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDR----- 585
            ..:|||:||... ||:.:.::...:.|||. |...|...:|...|.::|...|::||.:.
plant   546 SYVDFTLPYTTSGVGMVVPLKDNVARSSLI-FFKPLTPGLWGMTLGSFFVVGFVVWILEHRVNSE 609

  Fly   586 -WSPYSYQNNREKYKDDEEKREFNLKECLWFCMTSL--TPQGGGEAPKNLSGRLVAATWWLFGFI 647
             ..|..||                :....||..:.:  .|:   |...:.:.|:|..||:....:
plant   610 FTGPPQYQ----------------ISTMFWFAFSIMVFAPR---ERVMSFTARVVVITWYFIVLV 655

  Fly   648 IIASYTANLAAFLTVSRLDTPVESLDD-LAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKD 711
            :..||||:|::.||..:|:....|:.: |||...:.|.
plant   656 LTQSYTASLSSLLTTQQLNPTETSIKNVLAKGGPVAYQ--------------------------- 693

  Fly   712 LSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKL-PATLDEAVARVRN---STAATGFAFL 772
               .||...   .||....:|             |::| |.|..|....:.|   |......||:
plant   694 ---RDSFVL---GKLRESGFP-------------ESRLVPFTSPEKCEELLNKGPSKGGVSAAFM 739

  Fly   773 GDATDIRYLQL---TNC-DLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEK 833
                ::.|:::   ..| ..::|...|....:......||.|....:.|||.:....:..:|:..
plant   740 ----EVPYVRVFLGQYCKKYKMVEVPFDVDGFGFVFPIGSPLVADVSRAILKVAESNKATQLETA 800

  Fly   834 WWKNDEALAKCDKP---EDQSDGISIQNIG-GVFIVIFVGIGMACITLVFEY 881
            |:||.:  ..|..|   .|.:..:|.:.:. ..|:::||.....|...:.::
plant   801 WFKNID--KTCPDPMNNPDPNPTVSFRKLSLDSFLLLFVAAATVCTLALLKF 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	78/475 (16%)
		PBP2_iGluR_putative	438..836	CDD:270435	84/415 (20%)
		Lig_chan	565..870	CDD:278489	65/325 (20%)
GLR2.4	NP_001328410.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910