DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and GLR1.4

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_187408.2	Gene:	GLR1.4 / 819940	AraportID:	AT3G07520	Length:	861	Species:	Arabidopsis thaliana

Alignment Length:	979	Identity:	189/979 - (19%)
Similarity:	340/979 - (34%)	Gaps:	269/979 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LWLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIRYGLSVQLDSIE 76
            ::.|.|:|...:.|     .|.|..|      ||..|.          :.:::|.||.|.:.|:|
plant    15 IFFLAFISFAVTCS-----GTNQKDN------VDRLPV----------VYEDVRIGLVVDMGSME 58

  Fly    77 ANKSDAKVLLEA-----ICNKYATSIEKKQTPHLILDTTKSGIASETVKSFTQALGLPTISASYG 136
            .......:.:..     :.|.|.|.:.       :|.....|...:.:.:....|....:.|..|
plant    59 GKLVTTSISMALSDFYHVNNGYRTRVS-------VLSRDSHGDPLQALAAAMDLLQTEQVEALVG 116

  Fly   137 QQG--DLRQWRDLDE------------------AKQKYLLQVMPPADIIPEAIRSIVIHMNITNA 181
            .|.  :.:...:|.|                  ||..|.:|.........:.|.::..:.:...|
plant   117 GQSLLEAKNLAELGEKTKVPVISSFQVPSSLSLAKYNYFIQATHDTSSEAKGIAALFSNFDWRTA 181

  Fly   182 AILYDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKRE-----REEQIEKLRNLDINNFFILGTLQ 241
            .::|:|    |..::..:|.:.......||..:.|.|     .||.|.|    .:..|...|...
plant   182 VLIYED----DDDWRESIQPLVGHFQQNAIHIEYKAEFSVSSNEECIMK----QLRKFKASGIRI 238

  Fly   242 SIRMVLESVKPAYF---------ERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGL 297
            .:..:.|.:....|         |..:||                  |:..:.|  ..::|
plant   239 FVAHISERIANRLFPCARRLGMMEEGYAW------------------ILTARSM--NNFQD---- 279

  Fly   298 LRTTYNLNEE-----------PQLSSAFYFDLALRSFLTIKE----MLQSGAWPKDMEYLNCDDF 347
              |.|...||           |.......|.|..:..|.::|    |.....|..|:.:......
plant   280 --TNYLAKEEMEGVIGFKSYIPLTEELHNFTLRWKRSLRLEEVVTRMSVCSIWAHDIAWSLARAA 342

  Fly   348 QGGNTPQRNLDLRDYFTKITEPTSY----GTFDLVTQSTQPFNGHSFM--KFEMDINVLQIRGGS 406
            :....|  .|.:.|....|.|...:    |....:.:        .|:  |||: :|::. ||
plant   343 EVAKLP--GLSVYDLLEAIPESAKHKGLSGDIKFIDK--------KFISDKFEI-VNMIG-RG-- 393

  Fly   407 SVNSKSIGKWISG---------LNS----ELIV--------------KDEEQMKN------LTAD 438
               .:|:|.|.||         |:|    |.|:              |::...|.      :.|.
plant   394 ---ERSVGLWNSGSFISNRRRRLSSTKALETIIWPGGSTRIPKIRSLKEKRHGKKKKLRVLVPAG 455

  Fly   439 TVYRIFTVVQAPFIMRDETAPKGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGI 503
            .:......|:..|    :|......|||||:..  .:|:.|:|   |||...:........:|.:
plant   456 NITPQILEVKTDF----KTGVTAATGYCIDVFE--TSILPFNY---EVEYIPWPGAINYKNYNDL 511

  Fly   504 VKKLMDK--QADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPSSLFKFLTVLETNVW 566
            |..|..:  :.|..:|.:::...|.:.:|||:|:.|: |:.::..:..|...:||.||:   ::|
plant   512 VYTLYSQKDKYDAAVGDITITDNRSLYVDFTLPFTDM-GLAVVTAKDKSMWIIFKPLTL---SLW 572

  Fly   567 LCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLWFCMTSLTPQGGGEAPKN 631
            |.|.:.:..|..::|:.:|.....:|.:..:          .:...|.|..::|..........|
plant   573 LTIASFFILTGAIVWLIERHDNADFQGSCFQ----------QIGTLLCFGFSTLVFAHRERLQHN 627

  Fly   632 LSGRLVAATWWLFGFIIIAS-YTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYF 695
            :|..:|..  |:|..:|:.| |||.|.:.:||.::
plant   628 MSRFVVIV--WIFAVLILTSNYTATLTSVMTVQQI------------------------------ 660

  Fly   696 ERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAVARV 760
                          :.|..|:::.....|..|   ..|:|..|......:..|   |.|:....:
plant   661 --------------RGLKSNENIGFFSASIAA---NVVNDNPTFQGPRYKGLK---TADDFTNAL 705

  Fly   761 RNSTAATGFAFLGDATDIRYLQL----TNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTL 821
            ||.|    .:|:.|  ::.|::|    ...:..:|..|.....:..|.|:||.|..:.:..|..|
plant   706 RNGT----ISFIVD--EVPYVKLFVAKHPSEFVIVETESVTNGFGFAFQKGSPLVQKVSREIEKL 764

  Fly   822 LNKRQLEKLK--EKWWKNDEALAKCDKPEDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWY 884
               |:.||||  |.||...:..:...  ||....:::....|:|::  .|:..|...:|:...|.
plant   765 ---RRTEKLKAIENWWFQRQTTSATS--EDTFHPLTVYTFRGLFMI--TGVSFAFALIVYLIPWN 822

  Fly   885 RYRK 888
            |.::
plant   823 REQR 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	81/458 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	87/406 (21%)
		Lig_chan	565..870	CDD:278489	61/311 (20%)
GLR1.4	NP_187408.2	PBP1_GABAb_receptor	47..410	CDD:107361	75/420 (18%)
		ANF_receptor	64..390	CDD:279440	62/377 (16%)
		GluR_Plant	448..778	CDD:270404	88/413 (21%)
		Periplasmic_Binding_Protein_Type_2	476..>657	CDD:304360	49/201 (24%)
		Lig_chan	570..810	CDD:278489	62/314 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910