DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and GLR2.7

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_180476.3	Gene:	GLR2.7 / 817460	AraportID:	AT2G29120	Length:	952	Species:	Arabidopsis thaliana

Alignment Length:	1038	Identity:	193/1038 - (18%)
Similarity:	371/1038 - (35%)	Gaps:	300/1038 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MILMNPKTSKILWLLGFLSLLSSFSLE---IAAQTTQNIN---VLFINEVDNEPAAKAVEVVLT- 58
            |.:|||:.:...::..|:..:..|.|.   :....|..|.   ||.::...::....::.:.|:
plant     1 MKVMNPRKTNNTFMYYFVLFVCGFVLMEGCLGQNQTTEIKVGVVLDLHTSFSKLCLTSINISLSD 65

  Fly    59 YLKKNIRY--GLSVQL-DSIEANKSDAKVLLEAICNKYATSI----------------EKKQTPH 104
            :.|.:..|  .|::.: ||:|.....:...|:.|.|:..::|                :|.|.|.
plant    66 FYKYHSDYTTRLAIHIRDSMEDVVQASSAALDLIKNEQVSAIIGPRTSMQAEFMIRLADKSQVPT 130

  Fly   105 LILDTTKSGIAS--------ETVKSFTQALGLPTISASYGQQGDLRQWRD-----LDEAKQKYLL 156
            :....|...:.|        .|:...:|...:..|..|:|       ||:     :|....:.:|
plant   131 ITFSATCPLLTSINSPYFVRATLDDSSQVKAIAAIVKSFG-------WRNVVAIYVDNEFGEGIL 188

  Fly   157 QVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDHKYKSLLQNIQTRHVITA----------- 210
            .::  .|.:.:....:|....|...|   :|..::...||  |..:|||..:..
plant   189 PLL--TDALQDVQAFVVNRCLIPQEA---NDDQILKELYK--LMTMQTRVFVVHMPPTLGFRFFQ 246

  Fly   211 --------------IAKDG------KREREEQIEKLRNLDINNFFILGT---------LQSIRMV 246
                          :..||      ..||...:|.::.       :||.         |::.|:.
plant   247 KAREIGMMEEGYVWLLTDGVMNLLKSNERGSSLENMQG-------VLGVRSHIPKSKKLKNFRLR 304

  Fly   247 LESVKPAY---FERNF----AWHAITQNEGEISSQRDN-ATIMFMKPMAYTQYRDRLGLLRTT-Y 302
            .|.:.|..   .|.|.    |:.:||..  .::.::.| .::.:..|:|....:..||.|..: |
plant   305 WEKMFPKKGNDEEMNIFALRAYDSITAL--AMAVEKTNIKSLRYDHPIASGNNKTNLGTLGVSRY 367

  Fly   303 NLNEEPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNTPQRNLDLRDYFTKIT 367
            ..:....||:..:..|| ..|..|...|:|..:    :.:|.
plant   368 GPSLLKALSNVRFNGLA-GEFELINGQLESSVF----DVINI----------------------- 404

  Fly   368 EPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRGGSSV---NSKSIGK-WISGLNSELIVKD 428
                .|:.:.:....:|.||....|.:...:||..|.|..:   .||.:.| |....|.:::
plant   405 ----IGSEERIIGLWRPSNGIVNAKSKNTTSVLGERLGPVIWPGKSKDVPKGWQIPTNGKML--- 462

  Fly   429 EEQMKNLTADTVYRIFTVVQAPFI---------MRDETAPKGYKGYCIDLINEIAAIVHFDYTIQ 484
                         |:...|:..|:         :.:...|   .||||::...:...:.:....:
plant   463 -------------RVGIPVKKGFLEFVDAKIDPISNAMTP---TGYCIEIFEAVLKKLPYSVIPK 511

  Fly   485 EVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPS 549
            .:   .|.:.|||  ::.:|.::.....|..:|.::::|.|.:.:|||:||.: .|:::|:....
plant   512 YI---AFLSPDEN--YDEMVYQVYTGAYDAVVGDVTIVANRSLYVDFTLPYTE-SGVSMMVPLKD 570

  Fly   550 SPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFD-------RWSPYSYQNNREKYKDDEEKREF 607
            :.:: :.||.....::|:.....:.|..|::||.:       |..|:                 .
plant   571 NKNT-WVFLRPWSLDLWVTTACFFVFIGFIVWILEHRVNTDFRGPPH-----------------H 617

  Fly   608 NLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESL 672
            .:....||..:::......:...||: |.|...|.....::|.||||||.:|.||..|...|.:.
plant   618 QIGTSFWFAFSTMNFAHREKVVSNLA-RFVVLVWCFVVLVLIQSYTANLTSFFTVKLLQPTVTNW 681

  Fly   673 DDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSL-----TAVERSKLAVWDYP 732
            .||.|..|.:     |....|:..          |:.|....::|.     :|||..:|
plant   682 KDLIKFNKNI-----GYQRGTFVR----------ELLKSQGFDESQLKPFGSAVECDEL------ 725

  Fly   733 VSDKYTKMWQAMQEAKLPATLDEAVARVR-----NSTAATGFAFLGDATDIRYLQLTNCDLQVVG 792
                       .....:.|:.|| ||.::     ||:..|                      :|.
plant   726 -----------FSNGTITASFDE-VAYIKVILSQNSSKYT----------------------MVE 756

  Fly   793 EEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPED-------- 849
            ..|....:.....:.|.|.|..:.|||.:....:::.::.||:|         ||.:
plant   757 PSFKTAGFGFVFPKKSPLTDDVSRAILNVTQGEEMQHIENKWFK---------KPNNCPDLNTSL 812

  Fly   850 QSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRIIDVAEANAERSNAADHPGKL 912
            .|:.:|:.:..|:|::..:...:|.:..|..   :.|.....:.|.:| |:.|       |||
plant   813 SSNHLSLSSFWGLFLIAGIASFLALLIFVAN---FLYEHKHTLFDDSE-NSFR-------GKL 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	82/471 (17%)
		PBP2_iGluR_putative	438..836	CDD:270435	83/423 (20%)
		Lig_chan	565..870	CDD:278489	64/329 (19%)
GLR2.7	NP_180476.3	PBP1_GABAb_receptor	40..421	CDD:107361	73/435 (17%)
		ANF_receptor	54..405	CDD:279440	68/405 (17%)
		GluR_Plant	460..799	CDD:270404	82/437 (19%)
		Lig_chan	584..832	CDD:278489	64/329 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.910