DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and GLR2.8

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001324459.1	Gene:	GLR2.8 / 817459	AraportID:	AT2G29110	Length:	948	Species:	Arabidopsis thaliana

Alignment Length:	1016	Identity:	205/1016 - (20%)
Similarity:	361/1016 - (35%)	Gaps:	284/1016 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LMNPKTSKILWLLGFLSLLSSFSLEIAAQTTQNIN---VLFINEVDNEPAAKAVEVVLTYLKK-- 62
            :||||.:...:|..|:.|.....:.:.......|.   ||.:|...::....::.:.|:...|
plant     1 MMNPKKNNNTFLSYFVCLFLLLEVGLGQNQISEIKVGVVLDLNTTFSKICLTSINLALSDFYKDH 65

  Fly    63 -NIRYGLSVQL-DSIEANKSDAKVLLEAICNKYATSI----------------EKKQTPHLILDT 109
             |.|..|::.: ||::.....:...|:.|.|:..::|                .|.|.|.:....
plant    66 PNYRTRLALHVRDSMKDTVQASAAALDLIQNEQVSAIIGPIDSMQAKFMIKLANKTQVPTISFSA 130

  Fly   110 TK---SGIASE-----TVKSFTQALGLPTISASYGQQGDLRQWR---------DLDEAKQKYLL- 156
            |.   :.|.|:     |:....|...:..|..|:|       ||         :|.|....||.
plant   131 TSPLLTSIKSDYFVRGTIDDSYQVKAIAAIFESFG-------WRSVVAIYVDNELGEGIMPYLFD 188

  Fly   157 ---QVMPPADIIP-EA----------------IRSIVIHMNITNAAILYDDSF---VMDHKYKSL 198
               .|.....:|| ||                .|..|:||....|:.:::.:.   :|:..|..|
plant   189 ALQDVQVDRSVIPSEANDDQILKELYKLMTRQTRVFVVHMASRLASRIFEKATEIGMMEEGYVWL 253

  Fly   199 LQNIQT---RHV-----ITAIAKDG---------------------KREREEQIEKLR-NLDINN 233
            :.|..|   ||:     :..|  ||                     ||..:::...|| :|.|..
plant   254 MTNGMTHMMRHIHHGRSLNTI--DGVLGVRSHVPKSKGLEDFRLRWKRNFKKENPWLRDDLSIFG 316

  Fly   234 FFILGTLQSIRMVLESVKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLL 298
            .:...:..::.|.:|....:.|..|.|           |...:|.|              .||.|
plant   317 LWAYDSTTALAMAVEKTNISSFPYNNA-----------SGSSNNMT--------------DLGTL 356

  Fly   299 RTT-YNLNEEPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGN-------TPQR 355
            ..: |..:....||...:..||.| |..|...|:|   || .|.:|   |.|..       ||
plant   357 HVSRYGPSLLEALSEIRFNGLAGR-FNLIDRQLES---PK-FEIIN---FVGNEERIVGFWTP-- 411

  Fly   356 NLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRGGSSVNSKSIGKWISGL 420
                           |.|..::.:..|..|.|..|       ..|...|.|::..|.   |....
plant   412 ---------------SNGLVNVNSNKTTSFTGERF-------GPLIWPGKSTIVPKG---WEIPT 451

  Fly   421 NSELIVKDEEQMKNLTADTVYRIFTVVQAPFIMRDETAPKGYKGYCIDLINEIAAIVHFDYTIQE 485
            |.:.|.......|..     :....|:..|  :.:.|.|   |||.||:..  ||:....|::..
plant   452 NGKKIKVGVPVKKGF-----FNFVEVITDP--ITNITTP---KGYAIDIFE--AALKKLPYSVIP 504

  Fly   486 VEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQ-RPS 549
             :..:|.:.|::  ::.:|.|:.:...|..:|.:::.|.|.:..|||:||.: .|:::|:. |.:
plant   505 -QYYRFESPDDD--YDDLVYKVDNGTLDAVVGDVTITAYRSLYADFTLPYTE-SGVSMMVPVRDN 565

  Fly   550 SPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFD-------RWSPYSYQNNREKYKDDEEKREF 607
            ...:.:.||.....::|:.....:....|::|:|:       |..|:                 .
plant   566 ENKNTWVFLKPWGLDLWVTTACFFVLIGFVVWLFEHRVNTDFRGPPH-----------------H 613

  Fly   608 NLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESL 672
            .:....||..:::......:...||: |.|...|.....::..||||||.:||||.|......::
plant   614 QIGTSFWFSFSTMVFAHREKVVSNLA-RFVVVVWCFVVLVLTQSYTANLTSFLTVQRFQPAAINV 677

  Fly   673 DDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYE---IWKDLSLNDSLTAVERSKLAVWDYPVS 734
            .||.|         ||             :.:.|:   ..||..:.:....   |||
plant   678 KDLIK---------NG-------------DYVGYQHGAFVKDFLIKEGFNV---SKL-------- 709

  Fly   735 DKYTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRYLQL---TNCD-LQVVGEEF 795
                         |...:.:|..|.:.|.:.:..|      .::.||:.   ..|. ..:|...|
plant   710 -------------KPFGSSEECHALLSNGSISAAF------DEVAYLRAILSQYCSKYAIVEPTF 755

  Fly   796 SRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWW--KNDEALAKCDKPED--QSDGISI 856
            ....:..|..:.|.|....:.|||.:....:::.::.||:  :||     |..|:.  .|:.:|:
plant   756 KTAGFGFAFPRNSPLTGDVSKAILNVTQGDEMQHIENKWFMKQND-----CPDPKTALSSNRLSL 815

  Fly   857 QNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRIIDVAE 897
            ::..|:|::..:...:|.:..||   .:.|.....:.|.:|
plant   816 RSFWGLFLIAGIASFLALLIFVF---LFLYENRHTLCDDSE 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	96/484 (20%)
		PBP2_iGluR_putative	438..836	CDD:270435	83/414 (20%)
		Lig_chan	565..870	CDD:278489	61/322 (19%)
GLR2.8	NP_001324459.1	PBP1_GABAb_receptor_plant	35..419	CDD:380645	88/442 (20%)
GLR2.8	NP_001324459.1	GluR_Plant	454..795	CDD:270404	84/426 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.910