DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and GLR2.3

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001325281.1	Gene:	GLR2.3 / 817007	AraportID:	AT2G24710	Length:	919	Species:	Arabidopsis thaliana

Alignment Length:	985	Identity:	191/985 - (19%)
Similarity:	355/985 - (36%)	Gaps:	245/985 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KTSKILWLLGFLSLLSSFSLEIAAQTTQN-----INVLFINEVDNEPAAKAVEVVLTYLKKNIR- 65
            :|.|:     |..:|..|...:.....||     ::|..:.:||...:    :||:..:..:|.
plant    26 RTEKL-----FFCILLVFFFCLEFNRGQNNGKTLVDVGVVTDVDTSHS----KVVMLCINMSISD 81

  Fly    66 -YGLSVQLD-----SIEANKSD----AKVLLEAICNKYATSIEKKQT---PHLILDTTKSGIASE 117
             |..:.|.:     ::..:|||    |...|:.|.||...:|....|   .|.:::
plant    82 FYSSNPQFETRLVVNVGDSKSDVVGAAIAALDLIKNKQVKAILGPWTSMQAHFLIE--------- 137

  Fly   118 TVKSFTQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAA 182
                ..|...:|.:  ||.....:     |...:..|.|:.........:.|::|:.........
plant   138 ----IGQKSRVPIV--SYSATSPI-----LTSLRSPYFLRATYEDSFQVQPIKAIIKLFGWREVV 191

  Fly   183 ILY-DDSF---VMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLD-------INNFFI 236
            .:| |::|   :|. :....||:|..|....::......:.|..:|.|:.::       ::.::.
plant   192 PVYIDNTFGEGIMP-RLTDALQDINVRIPYRSVIAINATDHEISVELLKMMNMPTRVFLVHMYYD 255

  Fly   237 LGTLQSIRMVLESVKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTT 301
            |.:    |..:::.:....|..:.|  |..| |.|..      :..:...|.......||:  .|
plant   256 LAS----RFFIKAKELGLMEPGYVW--ILTN-GVIDD------LSLINETAVEAMEGVLGI--KT 305

  Fly   302 YNLNEEPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNTPQRNLDLRDYFTKI 366
            | :.:.|.|..   |....||.....|:...|.|..|.........:...|  .|:.    |:|:
plant   306 Y-IPKSPDLEK---FRSRWRSLFPRVELSVYGLWAYDATTALAVAIEEAGT--NNMT----FSKV 360

  Fly   367 TEP------------TSYGTFDLVTQSTQPFNG----HSFMKFEMDINVLQIRGGSSVNSKSIGK 415
            .:.            :.:|...|.|..|..|.|    ..|.:.::..:|.:|....:...||||.
plant   361 VDTGRNVSELEALGLSQFGPKLLQTLLTVQFRGLAGEFRFFRGQLQPSVFEIVNIINTGEKSIGF 425

  Fly   416 WISGLNSELIVKDEEQMKNLTA-----DTVYRIFTVVQAPFIMRDETAPKGYK------------ 463
            |..|  :.|:.|.::|..:::|     |.:..|....:|      ::.|||::
plant   426 WKEG--NGLVKKLDQQASSISALSTWKDHLKHIVWPGEA------DSVPKGWQIPTKGKKLRIGV 482

  Fly   464 ------------------------GYCID----LINEIAAIVHFDYTIQEVEDGKFGNMDENGQW 500
                                    |:|||    :|.|:...|.:::...|..|||..     |.:
plant   483 PKRTGYTDLVKVTRDPITNSTVVTGFCIDFFEAVIRELPYDVSYEFIPFEKPDGKTA-----GNY 542

  Fly   501 NGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDL-VGITIMMQRPSSPSSLFKFLTVLETN 564
            |.:|.::...:.|..:|..:::..|...:|||.|:... ||:.:.|..|.....:. |:..|...
plant   543 NDLVYQVYLGRYDAVVGDTTILVNRSSYVDFTFPFIKSGVGLIVEMTDPVKRDYIL-FMKPLSWK 606

  Fly   565 VWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLWFCMTSLTPQGGGEAP 629
            :||....::|.....:|:.:      |:.|    .|......|......||..:::.     .||
plant   607 LWLTSFISFFLVGCTVWVLE------YKRN----PDFSGPPRFQASTICWFAFSTMV-----FAP 656

  Fly   630 K----NLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSS 690
            :    :...|.:...|:....::..||||:||:.||..:|:..:.|:..|.::           .
plant   657 RERVFSFWARALVIAWYFLVLVLTQSYTASLASLLTSQKLNPTITSMSSLLEK-----------G 710

  Fly   691 AMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLP----A 751
            ....::|.|.|                     ..||....:|            |.:.:|    .
plant   711 ETVGYQRTSFI---------------------LGKLKERGFP------------QSSLVPFDTAE 742

  Fly   752 TLDEAVARVRNSTAATGFAFLGDATDIRYLQL---TNCD-LQVVGEEFSRKPYAIAVQQGSHLKD 812
            ..||.:::.......:| |||    :|.||:|   ..|: .::|.|.|:...:......||.|..
plant   743 ECDELLSKGPKKGGVSG-AFL----EIPYLRLFLGQFCNTYKMVEEPFNVDGFGFVFPIGSPLVA 802

  Fly   813 QFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKP---EDQSDGISIQNIG-GVFIVIFVGIGMA 873
            ..:.|||.:....:..:|:..|:|..|  ..|..|   .|.:...:.:.:. ..|:.:|||:.:.
plant   803 DVSRAILKVAESPKAMELERAWFKKKE--QSCPDPITNPDPNPSFTSRQLDIDSFLFLFVGVLLV 865

  Fly   874 CITLV--FEY 881
            |:..:  |.|
plant   866 CVMALGNFTY 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	80/426 (19%)
		PBP2_iGluR_putative	438..836	CDD:270435	88/450 (20%)
		Lig_chan	565..870	CDD:278489	63/320 (20%)
GLR2.3	NP_001325281.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910