DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and GLR2

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001318239.1	Gene:	GLR2 / 816231	AraportID:	AT2G17260	Length:	925	Species:	Arabidopsis thaliana

Alignment Length:	1072	Identity:	209/1072 - (19%)
Similarity:	387/1072 - (36%)	Gaps:	312/1072 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SKILW-LLGFLSLLSS---------------------FSLEIAAQTTQNINVLFINE-VDNEPA- 49
            |.:.| ||.|:.:|..                     |.|......|.||......| |:::|:
plant     3 SSMNWVLLSFIIVLGGGLLLSEGASSSRPPVIKVGAIFGLNTMYGETANIAFKAAEEDVNSDPSF 67

  Fly    50 --AKAVEVVLTYLKKNIRYGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKS 112
              ...:.:::...|   |.|....:.:::..::|...::..     .|||......||..:.|
plant    68 LGGSKLRILMNDAK---RSGFLSIMGALQFMETDVVAIIGP-----QTSIMAHVLSHLANELT-- 122

  Fly   113 GIASETVKSFTQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMN 177
                ..:.||| ||. ||:|                ..:..:.:|..|....:..||..::.:..
plant   123 ----VPMLSFT-ALD-PTLS----------------PLQFPFFVQTAPSDLFLMRAIAEMITYYG 165

  Fly   178 ITNAAILYDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKRERE---------------------- 220
            .::...||:|             :..:|:.:||:. |...||.
plant   166 WSDVVALYND-------------DDNSRNGVTALG-DELEERRCKISYKAVLPLDVVITSPVEII 216

  Fly   221 EQIEKLRNLD-----INNFFILGTLQSIRMVL-ESVKPAYFERNFAWHAITQNEGEISSQRDN-- 277
            |::.|:|.::     :|.|...|     :|:. |:.:....|:.:.|.|.|.    :||..|:
plant   217 EELIKIRGMESRVIVVNTFPNTG-----KMIFKEAERLGMMEKGYVWIATTW----LSSVLDSNL 272

  Fly   278 ----------ATIMFMKPMA------YTQYRDRLGLLRTTYNLNEEPQLSSAFYFDLALRSFLTI 326
                      .|:....|.:      ..:::::|. ...|..||    :...:.:|........:
plant   273 PLDTKLVNGVLTLRLHTPDSRKKRDFAARWKNKLS-NNKTIGLN----VYGLYAYDTVWIIARAV 332

  Fly   327 KEMLQSGAWPKDMEYLNCDDFQGGNTPQRNLDLR------------DYF--TK---ITEPT---- 370
            |.:|::|.   ::.:.|  |.:.|:.....|:|.            ||.  ||   :|.|.
plant   333 KTLLEAGG---NLSFSN--DAKLGSLKGEALNLSALSRFDQGSQLLDYIVHTKMSGLTGPVQFHP 392

  Fly   371 -------SYGTFDLVTQSTQP------FNGHSFMKFE-------------MDINVLQIRGGSSVN 409
                   ||...:||......      ::|.|.:..|             ..:|.:...||:||.
plant   393 DRSMLQPSYDIINLVDDRVHQIGYWSNYSGLSIVPPESFYSKPPNRSSSNQHLNSVTWPGGTSVT 457

  Fly   410 SKSIGKWI---SGLNSELIVKDEEQMKNLTADTVYRIFTVVQAPFIMRDETAPKGYKGYCIDLIN 471
            .:.   ||   :|....:.|.|....|:                |:.|...:....:|||||:..
plant   458 PRG---WIFRNNGRRLRIGVPDRASFKD----------------FVSRVNGSSNKVQGYCIDVFE 503

  Fly   472 EIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKL-MDKQADIGLGSMSVMAEREIVIDFTVPY 535
              ||:....|.:.. |...||:...|..:|.:|.|: .....|..:|.::::.:|..::|||.||
plant   504 --AAVKLLSYPVPH-EFIFFGDGLTNPNYNELVNKVTTGVDFDAVVGDIAIVTKRTRIVDFTQPY 565

  Fly   536 YD--LVGITIMMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKY 598
            .:  ||.:..:.:...:|   :.||......:|....:.:......:||.:       ....:::
plant   566 IESGLVVVAPVTRLNENP---WAFLRPFTLPMWAVTASFFVIVGAAIWILE-------HRINDEF 620

  Fly   599 KDDEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVS 663
            :....::...:   |||..:::. ....|...:..||:|...|.....||.:||||:|.:.|||.
plant   621 RGPPRRQIITI---LWFTFSTMF-FSHRETTVSTLGRMVLLIWLFVVLIITSSYTASLTSILTVQ 681

  Fly   664 RLDTPVESLDDLAKQ-----YKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVER 723
            :|::|::.:|.|...     :::      ||.|..|                   :.|.|. :..
plant   682 QLNSPIKGVDTLISSTGRIGFQV------GSFAENY-------------------MTDELN-IAS 720

  Fly   724 SKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRYLQL---TN 785
            |:|.....|  ::|.   .|:|...:.|.:||.                      .|:.|   ..
plant   721 SRLVPLASP--EEYA---NALQNGTVAAIVDER----------------------PYIDLFLSDY 758

  Fly   786 CDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQ 850
            |...:.|:||:|..:..|..:.|.|....:.|||.|....:|:|:.::|...    :.|..|...
plant   759 CKFAIRGQEFTRCGWGFAFPRDSPLAVDMSTAILGLSETGELQKIHDRWLSK----SNCSSPHGS 819

  Fly   851 SDG----ISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRII-----DVAEANAERSNAA 906
            ..|    :::.:..|:|:|    :|:||:..:|.:::       :||     |..|...|.:..:
plant   820 QSGDSEQLNVHSFWGMFLV----VGIACLVALFIHFF-------KIIRDFCKDTPEVVVEEAIPS 873

  Fly   907 DHPGKLVD-GVILGHSGEKFEKSKAALRPRFN 937
            ....:|.. ...|....||.|::|..|:.:.|
plant   874 PKSSRLTKLQTFLAFVDEKEEETKRRLKRKRN 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	85/485 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	87/408 (21%)
		Lig_chan	565..870	CDD:278489	63/316 (20%)
GLR2	NP_001318239.1	PBP1_GABAb_receptor	35..424	CDD:107361	80/453 (18%)
		GluR_Plant	468..808	CDD:270404	89/425 (21%)
		Lig_chan	594..843	CDD:306551	64/320 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910