DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and grik5

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001315085.1	Gene:	grik5 / 798791	ZFINID:	ZDB-GENE-070821-6	Length:	1067	Species:	Danio rerio

Alignment Length:	916	Identity:	251/916 - (27%)
Similarity:	413/916 - (45%)	Gaps:	170/916 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 INEVDNEPAAKAVEVVLTYLKKNIRYGLSVQLDSI----------EANKSDAKVLLEAICNKYAT 95
            ||.|...||...|||.:..|:|:.:|..:..:..|          .|:...:..::..||.
Zfish    64 INSVMENPARARVEVDIFELQKDSQYETTDTMCQILPKGVVSVIGPASSPASGSIVSHICG---- 124

  Fly    96 SIEKKQTPHLILDTTKS------GIASETV----KSFTQALGLPTISASYGQQGDLRQWRDLDEA 150
               :|:.||:.:...::      ..||.|:    :..:.|:|....|.||..       ..|..|
Zfish   125 ---EKEIPHVKIGPEETPRLPYLRFASVTLYPSNEDLSLAIGSILRSFSYPS-------ASLVCA 179

  Fly   151 KQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDHKYKSLLQNIQTRHVITAIAKDG 215
            |.:.||:       :.|.||..:|.....:..:|.|:   :|.  ..||:.|:...:.|.|....
Zfish   180 KAECLLR-------LEELIRRFLISRETLSIRMLDDN---LDP--TPLLKEIRDDKIATIIIDAN 232

  Fly   216 KREREEQIEKLRNLDINNFF---ILGTLQSIRMVLESVKPAYFERNFAWHAITQNEGEISSQRDN 277
            .......::|...|.:.:.|   ||.|:....:.|:.:             :.:....:.....|
Zfish   233 ASISYLILKKASELGMTSAFYKYILTTMDFPLLWLDDI-------------VDEQSNIVGFSMFN 284

  Fly   278 ATIMFMKPMAYTQYRDRLGL-LRTTYNLN--EEPQLSSAFYFDLALRSFLTIKEMLQS---GAWP 336
            .|..|     |.::...|.| .|...::|  ..|.||||..||........::|:.:|   |..|
Zfish   285 TTHPF-----YLEFIRSLNLSWREGCDINPYPGPALSSALLFDAVHVVVSAVQELNRSQEIGVKP 344

  Fly   337 KDMEYLNCDDFQGGNTP---QRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDIN 398
                 |:|      .:|   |....|.:|...:       .:|.:|...: ||... .:....::
Zfish   345 -----LSC------TSPQIWQHGTSLMNYLRMV-------EYDGLTGRVE-FNSKG-QRTNYTLH 389

  Fly   399 VLQ-IRGGSSVNSKSIGKWISGLNSELIVKDEEQMKNLT---ADTVYRIFTVVQAPFIMR----- 454
            :|: .|||    .|.||.|.|  |:.|::.......|::   |:....|.|:::.|::||
Zfish   390 ILEKHRGG----HKEIGIWYS--NNTLLMNSTSLDINVSETLANKSLIITTILENPYVMRKINYQ 448

  Fly   455 DETAPKGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSM 519
            :....:.|:|:|:|::.|::.|:.|.|.|:.|:||.:|..:.||.|.|:|.:|::::||:.:.:.
Zfish   449 EFEGNEQYEGFCVDMLRELSDILKFTYRIKLVDDGLYGAPEPNGSWTGMVGELINRKADLAVAAF 513

  Fly   520 SVMAEREIVIDFTVPYYDLVGITIMM-----QRPSSPSSLFKFLTVLETNVWLCILAAYFFTSFL 579
            ::.:|||.||||:.|:..| ||:|:.     ::|    ..|.||......|||.:|.||...|.:
Zfish   514 TITSEREKVIDFSKPFMTL-GISILYRVHIGRKP----GYFSFLDPFSPAVWLFMLLAYLAVSCV 573

  Fly   580 MWIFDRWSPYSYQNNRE--KYKDDEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWW 642
            :::..|.|||.:.|...  :.:.|..:.::.|...|||.:.....||....|:.||.|.|:..||
Zfish   574 LFLSARLSPYEWYNPHPCLRERRDLLENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWW 638

  Fly   643 LFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYE 707
            .|..|||:||||||||||||.|::.|:||.||||.|..|.|..::|.|.||:|
Zfish   639 AFTLIIISSYTANLAAFLTVQRMEVPIESPDDLADQTNIQYGTIHGGSTMTFF------------ 691

  Fly   708 IWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFL 772
                  :|......:|    :|:|    .|:|     |.:....:.:|.:|||.||.    :|||
Zfish   692 ------MNSRYQTYQR----MWNY----MYSK-----QPSVFVKSTEEGIARVVNSK----YAFL 733

  Fly   773 GDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKN 837
            .::|...|.:..||:|..:|.....|.|.|.:..||..:|:.:.|:|.|....:||.||.:||:.
Zfish   734 LESTMNEYHRSLNCNLTQIGGLLDTKGYGIGMPLGSPFRDELSLAVLQLQENNRLEILKRRWWEG 798

  Fly   838 DEALAKCDKPED-QSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRIIDVAEANAE 901
                .||.|.|| ::.|:.::||||:|:|:..|:.:|....|.|:.|...|.       ||.:..
Zfish   799 ----GKCPKEEDHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFVWSTRRS-------AETDEV 852

  Fly   902 RSNAAD 907
            |..:.|
Zfish   853 RPLSCD 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	90/417 (22%)
		PBP2_iGluR_putative	438..836	CDD:270435	136/409 (33%)
		Lig_chan	565..870	CDD:278489	107/307 (35%)
grik5	NP_001315085.1	PBP1_iGluR_Kainate_KA1_2	38..412	CDD:107389	90/417 (22%)
		ANF_receptor	55..392	CDD:279440	79/391 (20%)
		Periplasmic_Binding_Protein_Type_1	<313..383	CDD:299141	21/89 (24%)
		Periplasmic_Binding_Protein_Type_2	427..797	CDD:304360	136/409 (33%)
		Lig_chan	558..828	CDD:278489	107/308 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591885
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840