Protein Alignment Ir25a and gria1a

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_991161.1
• Gene: gria1a / 798689
• ZFINID: ZDB-GENE-020125-1
• Length: 914
• Species: Danio rerio
• Alignment Length: 1021
• Identity: 253/1021 - (24%)
• Similarity: 422/1021 - (41%)
• Gaps: 306/1021 - (29%)

  Fly     9 SKILWLLGFLSLL--SSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIRYGLS-- 69
            |..|....||.|.  |||...|      ||..||..|      :...||        .|:.||
Zfish     4 SLTLLCTSFLGLCFGSSFPSNI------NIGGLFPTE------SHEYEV--------FRFALSHH 48

  Fly    70 -------VQLDSIEANKSDAKVLLEAICNKYA------TSIEKKQTPHLILDTTKSGIASETVKS 121
                   .|:|.::...|.:  :..|.|::::      ..:..::|.::::             |
Zfish    49 QDIPKLVPQVDMVKLGNSFS--MTYAFCSQFSKGVYAIIGVYDRKTVNMLM-------------S 98

  Fly   122 FTQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYD 186
            |..||.:..::.|:..           |...::::|:.|.   :.:|:..::.|...:....:|.
Zfish    99 FCGALHVCFVTPSFPM-----------ENSNQFVIQLRPE---LQDALVGVIEHYRWSKFVYMYS 149

  Fly   187 DSF-------VMD----HKYKSLLQNIQ--TRHVITAIAKDGKREREEQI------EKLRNLDIN 232
            ...       |:|    |.:.....|::  |......:.:|..:::|.||      |:|.::
Zfish   150 SDSGLSVLQKVLDTAAEHNWLVTSVNVETMTEASFLKVFQDLDKKKEGQIIIDCELERLTSI--- 211

  Fly   233 NFFILGTLQSIRMVLESVKPAYFERNFAWHAITQNEG-------EISSQRDNATIMFMKPMAYTQ 290
                   |:.|..:.::||        ::|.|..|.|       |......|.|
Zfish   212 -------LKKIIELGKNVK--------SYHYILANLGFLDIDLTEFKKGEANVT----------- 250

  Fly   291 YRDRLGLLRTTYNLNEEPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNTPQR 355
                 |.....|   .:|.:|.            |:::      |   ||:.|.|    ...|:|
Zfish   251 -----GFQLVNY---ADPNVSR------------TVQQ------W---MEFDNKD----AKVPKR 282

  Fly   356 NL-------------------DLRDYFTKITE-----------PTSYGTFDLVTQSTQP-----F 385
            .|                   :||.....|:.           |..:|....:.::.|.     .
Zfish   283 RLKYTGALTYDGVKVMSTAFQNLRRQRIDISRRGNAGECLANPPAPWGQGIDIQRALQQVRIEGL 347

  Fly   386 NGHSFMKF-------EMDINVLQIRGGSSVNSKSIGKWISGLNSELIVKDEEQMKNLTA------ 437
            .||  ::|       ...|:|:::|   ....|.:|.|          .::|:..:..|
Zfish   348 TGH--IQFNEKGRRTNYSISVMELR---PTGPKKVGYW----------NEDEKFVSTAAYMPGSN 397

  Fly   438 ------DTVYRIFTVVQAPFIMRDE-----TAPKGYKGYCIDLINEIAAIVHFDYTIQEVEDGKF 491
                  :..|.:.|::::|::|..:     |....|:|||::|..|||..|.:.|.::.|.|||:
Zfish   398 ETYGLQNRTYIVTTILESPYVMLKKNHEHFTGNDKYEGYCVELAAEIAKHVGYHYILKIVADGKY 462

  Fly   492 GNMD-ENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPS-SPSSL 554
            |..| |...|||:|.:|:..:||:.:..:::...||.||||:.|:..| ||:||:::|: |...:
Zfish   463 GARDAETMMWNGMVGELVYGKADVAVAPLTITLVREEVIDFSKPFMSL-GISIMIKKPTKSKPGV 526

  Fly   555 FKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSY------------------------QNNR 595
            |.||..|...:|:||:.||...|.::::..|:|||.:                        ||.:
Zfish   527 FSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHADDCEDGAEENPNQPSSSSAQPGQNQQ 591

  Fly   596 -EKYKDDEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAF 659
             :..:..|:..||.:...|||.:.:...||...:|::||||:|...||.|..|||:|||||||||
Zfish   592 NQNQQSQEQTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAF 656

  Fly   660 LTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERS 724
            |||.|:.:|:||.:|||||.:|.|..|:..|...:|                          .||
Zfish   657 LTVERMVSPIESAEDLAKQTEIAYGTLDAGSTKEFF--------------------------RRS 695

  Fly   725 KLAVWDYPVSDKYTKMWQAMQEAKLPA----TLDEAVARVRNSTAATGFAFLGDATDIRYL-QLT 784
            |:||::        |||..|:.|. |:    |.||.|.|||.|...  :|:|.::|...|: |..
Zfish   696 KIAVFE--------KMWSYMKSAD-PSVFVKTTDEGVMRVRKSKGK--YAYLLESTMNEYIEQRK 749

  Fly   785 NCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDK--- 846
            .||...||.....|.|.||..:||.|::..|.|:|.|..:..|:|||.|||.:.   .:|..
Zfish   750 PCDTMKVGGNLDSKGYGIATPKGSPLRNPVNLAVLKLNEQGLLDKLKNKWWYDK---GECGSGGG 811

  Fly   847 -PEDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPR 891
             .:|::..:|:.|:.|||.::..|:|:|.:..:.|: .|:.|...|
Zfish   812 DSKDKTSALSLSNVAGVFYILIGGLGLAMLVALVEF-CYKSRTESR 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	75/463 (16%)
		PBP2_iGluR_putative	438..836	CDD:270435	150/434 (35%)
gria1a	NP_991161.1	Periplasmic_Binding_Protein_type1	26..390	CDD:471960	78/483 (16%)
		PBP2_iGluR_AMPA_GluR1	404..806	CDD:270447	151/442 (34%)
		Lig_chan	536..835	CDD:459656	111/338 (33%)