Protein Alignment Ir25a and grik1a

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_009303592.2
• Gene: grik1a / 798001
• ZFINID: ZDB-GENE-030131-6502
• Length: 919
• Species: Danio rerio
• Alignment Length: 968
• Identity: 248/968 - (25%)
• Similarity: 430/968 - (44%)
• Gaps: 182/968 - (18%)

  Fly     7 KTSKILWLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAK---AVEVVLTYLKKN----- 63
            |..::|:.. |.|:...:   ::.|....|..:|... :|||.:.   |.:..:|.:.:|
Zfish    16 KRKRLLFFF-FYSMAKFY---LSEQQVIRIGGIFETR-ENEPVSMDELAFKFAVTSINRNRTLMP 75

  Fly    64 ---IRYGLS-VQL-DSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKSFT 123
               :.|.:. |.| ||.||::        .:|::.|..:.....|     :..|.:::  |:|..
Zfish    76 NTTLTYDIQRVNLFDSFEASR--------RVCDQLALGVAAVFGP-----SHSSSVSA--VQSIC 125

  Fly   124 QALGLPTISASYGQQGDLRQWR--DLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYD 186
            .||.:|.|..         :|:  .:|. |..:.:.:.|....|..||..|||........::|:
Zfish   126 NALEVPHIQT---------RWKHPSVDN-KDNFYINLYPEYTSISRAILDIVIFYKWKCVTVVYE 180

  Fly   187 DS---FVMDHKYKSLLQN---IQTRHVITA------IAKDGKRERE-------------EQIEKL 226
            ||   ..|....|:..:|   |:.|.:.:.      :.|:.|:|:|             |.:::|
Zfish   181 DSTGLMRMQELIKAPSKNNLKIRIRQLPSGGGDSRPLLKEMKKEKEFYVIFDCSYQVAAELLKQL 245

  Fly   227 RNLDINN---FFILGTLQSIRMVLESVKPAYFERNF-AWHAITQNEGEISS--QRDNATIMFMKP 285
            .::.:..   .|...||....:.||..:  |...|. |:..:..::..::|  |:.:.......|
Zfish   246 MSMGMMTEYYHFFFTTLDLFALDLEPYR--YSGVNMTAFRLLNLDDSYVASVIQKWSMERQLAPP 308

  Fly   286 MAYTQYRDRLGLLRTTYNLNEEPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNC------ 344
            ...:....  |::.|...|..:.....|.....|.:..::..:..:...|.....::|.
Zfish   309 KPESGLMS--GIMTTAAALMYDAVFMVAVASQRATQMTVSSLQCHRHKPWRYGPRFMNLFKEAQW 371

  Fly   345 DDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRGGSSVN 409
            |...|.....:...||..|          ..||::             .:.|....::..|:|..
Zfish   372 DGLTGRIVLNKTDGLRKEF----------NLDLIS-------------LKEDGTAKRVADGASRP 413

  Fly   410 SK---SIGKWIS--GLN-SELIVKDEEQMKNLTADTVYRIFTVVQAPFIM--RDETAPKG---YK 463
            :|   .||.|.|  ||| :|  :||.:.:.:..|:....:.|:::.|::|  :.:....|   ::
Zfish   414 NKLWTKIGVWNSYTGLNLTE--IKDNKNITDSLANRTLIVTTILENPYVMYKKSDKVLYGNDRFE 476

  Fly   464 GYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIV 528
            |||:||:.|::.|:.|.|.::.|.|||:|..::.|:|||:|::|:|..||:.:..:::...||.|
Zfish   477 GYCLDLLKELSNILGFTYEVKLVTDGKYGAQNDKGEWNGMVRELIDHIADLAVAPLTITYVREKV 541

  Fly   529 IDFTVPYYDLVGITIMMQRPSSPS-SLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQ 592
            |||:.|:..| ||:|:.::|:..: .:|.||..|..::|:.:|.|....|.::::..|::||.:.
Zfish   542 IDFSKPFMTL-GISILYRKPNGTNPGVFSFLNPLTPDIWMYVLLACLGVSCVLFVIARFTPYEWY 605

  Fly   593 NNREKYKDDE-EKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANL 656
            |........| .:..|.|...|||.:.:|..||....||.||.|::...||.|..|||:||||||
Zfish   606 NPHPCNPSSEVVENNFTLLNSLWFGVAALMRQGSELMPKALSTRILGGIWWFFTLIIISSYTANL 670

  Fly   657 AAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAV 721
            ||||||.|:|:|::|.||||||.:|.|..:...|.||:|
Zfish   671 AAFLTVERMDSPIDSADDLAKQTRIEYGAVRDGSTMTFF-------------------------- 709

  Fly   722 ERSKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAVARVRNS------TAATGFAFLGDATDIRY 780
            ::||::.        |.|||..|...|       ..|.|:||      ...|.:|.|.::|.|.|
Zfish   710 KKSKIST--------YEKMWAFMSSRK-------NTALVKNSKDGITRVLTTDYALLMESTSIEY 759

  Fly   781 LQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCD 845
            :...||:|..||.....|.|.:....||..:|:...|||.|..:.:|..:|||||:.:..
Zfish   760 ITQRNCNLTQVGGLIDSKGYGVGTPIGSPYRDKVTIAILQLQEEGKLHMMKEKWWRGNGC----- 819

  Fly   846 KPEDQS---DGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRIIDVAEANA 900
             ||:.|   ..:.::||||:|||:..|:.::....:.|: .|:..||..|.:....:|
Zfish   820 -PEEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEF-IYKSHKNSDIEECVSFSA 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	80/435 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	136/410 (33%)
grik1a	XP_009303592.2	None