Protein Alignment Ir25a and Grid1

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_077354.1
• Gene: Grid1 / 79219
• RGDID: 68366
• Length: 1009
• Species: Rattus norvegicus
• Alignment Length: 970
• Identity: 239/970 - (24%)
• Similarity: 415/970 - (42%)
• Gaps: 179/970 - (18%)

  Fly    12 LWLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAK---AVEVVLTYLKKN--------IR 65
            ||||.::         ....|.:..:::.|..:..|.|||   ..::.::.|..|        |.
  Rat     6 LWLLPWI---------CQCVTVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKIT 61

  Fly    66 YGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIAS-ETVKSFTQALGLP 129
            |.:.|    ||||.....|  :..|:        ..|..::...|.:|.|| ..::|.|.|:.:|
  Rat    62 YSIKV----IEANNPFQAV--QEACD--------LMTQGILALVTSTGCASANALQSLTDAMHIP 112

  Fly   130 TISASYGQQGDLRQWRDLDEAK--QKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYD------ 186
            .:.......|..|....|:.:.  :.|.|...||..:....:| :|..:......:.||
  Rat   113 HLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLR-LVTELRWQKFVMFYDSEYDIR 176

  Fly   187 --DSFV-------MDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQS 242
              .||:       :|...:.:.:||.  ||.|::....|   .|::.:.|:.......:|....:
  Rat   177 GLQSFLDQASRLGLDVSLQKVDKNIS--HVFTSLFTTMK---TEELNRYRDTLRRAILLLSPQGA 236

  Fly   243 IRMVLESVKPAYFERNFAWHAITQNEGE------ISSQRDNATIMFMKPMAYTQYRDRLGLLRTT 301
            ...:.|:|:.....::..|..:.:...:      :.|.....|::   ...:...:|....:|..
  Rat   237 HSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVV---RQIFPSAKDNQKCMRNN 298

  Fly   302 YNLNE---EP--------QLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNC-----DDFQGG 350
            :.::.   :|        |:|:.:.:|..|.........|:...| ..|..|||     ..:.||
  Rat   299 HRISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKW-HSMASLNCIRKSTKPWNGG 362

  Fly   351 NTPQRNLDL--RDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRGGSSVNSKSI 413
            .:   .||.  :.:.|.:|     |..:....|:.|     :::||       |.|  :..|::.
  Rat   363 RS---MLDTIKKGHITGLT-----GVMEFREDSSNP-----YVQFE-------ILG--TTYSETF 405

  Fly   414 GK-------WIS--GLNSELIVKDEEQMKNLTADTVYRIFTVVQAPFIMRDET---APKGYKGYC 466
            ||       |.|  |||..|   .|..|.:.......::.||::.||:|..|.   .||.|||:.
  Rat   406 GKDMRKLATWDSEKGLNGSL---QERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFS 467

  Fly   467 IDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDF 531
            ||:::.:|..:.|.|.|.:..||::|:...|..|||::.:|:.|:||:.:.::::..|||.|:||
  Rat   468 IDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDF 532

  Fly   532 TVPYYDLVGITIMMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQNNRE 596
            :..|.| ..:.|::::|....|:|......:..||.||.||......|:::.:|......|:..:
  Rat   533 SKRYMD-YSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRSQSATQ 596

  Fly   597 KYKDDEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLT 661
                ........|...:|....:...|||..:..:::.|:|..:||||..|:.:|||||||||||
  Rat   597 ----PRPSASATLHSAIWIVYGAFVQQGGESSVNSVAMRIVMGSWWLFTLIVCSSYTANLAAFLT 657

  Fly   662 VSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSN--IEQ--MFYEIWKDLSLNDSLTAVE 722
            |||:|:||.:..||:||.::.|..:..|:...||.....  :||  .|.|:|:.:|.|...
  Rat   658 VSRMDSPVRTFQDLSKQLEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGA---- 718

  Fly   723 RSKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRYLQLT--N 785
                   |..||:.                 .|.:.:.:..    .:|||.|...:.|..||  :
  Rat   719 -------DNCVSNP-----------------SEGIRKAKKG----NYAFLWDVAVVEYAALTDDD 755

  Fly   786 CDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCD---KP 847
            |.:.|:|...|.|.|.||:|.||..:|.|:..||.|.:...|:.||:|||.:   ..:||   ..
  Rat   756 CSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPH---TGRCDLTSHS 817

  Fly   848 EDQSDG--ISIQNIGGVFIVIFVGIGMACITLVFEYWWYR---YRKNPRIIDVAEANAER 902
            ..|:||  :.:.:..|||.::.:|:.:||:....|.||..   :::.|:  :..|.|.|:
  Rat   818 SAQTDGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQETPK--EDKEVNLEQ 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	83/440 (19%)
		PBP2_iGluR_putative	438..836	CDD:270435	125/406 (31%)
Grid1	NP_077354.1	Interaction with CBLN1. /evidence=ECO:0000250|UniProtKB:Q61627	21..436		90/463 (19%)
		PBP1_iGluR_delta_1	25..425	CDD:380615	87/445 (20%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	125/406 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..960