DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and Ir7f

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001138177.1	Gene:	Ir7f / 7354418	FlyBaseID:	FBgn0259188	Length:	621	Species:	Drosophila melanogaster

Alignment Length:	621	Identity:	116/621 - (18%)
Similarity:	203/621 - (32%)	Gaps:	178/621 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 SVKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTTYNLN-EEPQLSS 312
            |:..:|.|.:           .|..|.::|.:...:.:... ..:.|..|.||..:. ....|.:
  Fly    20 SIYKSYLENS-----------RIDMQGEDANLYVARALRLV-IENVLAQLSTTLVVTISTRHLGT 72

  Fly   313 AFYFDLALR-----------SFLTIKEMLQSGAWP--KDMEYLNCDDFQG-----GNTPQRNLDL 359
            |.:|:..:.           ..|.|:..|.....|  |.:..|..|.:||     ......|.|.
  Fly    73 AHWFEYMMNILMDSWRMVAVQLLRIRPDLVVNPVPGRKRVSLLMVDSYQGLLDTNITASNANFDD 137

  Fly   360 RDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVL---------------------QIR 403
            .||:....:...:    |:.:..|....|....|.:..||:                     |..
  Fly   138 PDYYFIFLQARDH----LIPKELQLILDHCLAHFWLHCNVMIQTAQVEVLVYTYYPYTADACQKA 198

  Fly   404 GGSSVNSKSIGKWISGLNSELIVKDEEQMKN--LTADTVYRIFTVVQAPFIMRDETA--PKGYK- 463
            ....||:....||.:   |::......||..  ||      :.|..|.||:   |..  ||..:
  Fly   199 YPIPVNTFDGRKWKA---SQMFPDKLSQMHGCPLT------VLTWHQPPFV---ELVWDPKHNRS 251

  Fly   464 ---GYCIDLINEIAAIVHFD-------------YTIQEVEDGKFGNMDENGQWNGIVKKLMDKQA 512
               |:.|.|:..:|..::|.             |.:.|            |...|.::||:.:..
  Fly   252 RGSGFEIQLVEHLARRMNFSLELVNIALLRPNAYRLAE------------GSSEGPIEKLLQRNV 304

  Fly   513 DIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTS 577
            :|.:|.....|.|..::...:.||....:.::........||...:...|.:||:.:|.|
  Fly   305 NISMGYFRKTARRNQLLTTPMSYYSANLVAVLQLERYRIGSLALLVFPFELSVWMLLLLA----- 364

  Fly   578 FLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLWFCMTSLTPQGGG--------------EA 628
             |:.......|.:.:.|.|                          .|||              ..
  Fly   365 -LLIHLGIHLPSARRGNEE--------------------------DGGGGLQVVALLLGAALARL 402

  Fly   629 PKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDL----------AKQYKILY 683
            |::...|.:||.|......:..||.:.|...:.:...:||..|||.|          |...::|.
  Fly   403 PRSWRHRFIAAHWLWASIPLRISYQSLLFHLIRLQLYNTPSFSLDQLLAEGFQGICTANTQRLLL 467

  Fly   684 A-------PLNGSSAMTYFE--------RMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPV 733
            .       |.:..|..|.|:        |..| .::|....:|::|:...::...:...|...||
  Fly   468 EMPQLARDPDSIQSVDTPFDWDVLNVLTRNRN-RKIFAVANQDVTLSFLHSSAHPNAFHVVKQPV 531

  Fly   734 SDKYTKMWQAMQEAKLPATLDEAVARVRNSTAATGF 769
            :.:|..|:.. :.:.|...:|:.:.|:    .|:||
  Fly   532 NVEYAGMYMP-KHSFLYEKMDDDIRRL----DASGF 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	38/216 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	74/390 (19%)
		Lig_chan	565..870	CDD:278489	47/244 (19%)
Ir7f	NP_001138177.1	Periplasmic_Binding_Protein_Type_2	231..>358	CDD:304360	27/141 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463115
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740