DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir25a and si:ch211-251b21.1

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001138274.1	Gene:	si:ch211-251b21.1 / 571720	ZFINID:	ZDB-GENE-060809-5	Length:	458	Species:	Danio rerio

Alignment Length:	506	Identity:	123/506 - (24%)
Similarity:	237/506 - (46%)	Gaps:	90/506 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   442 RIFTVVQAPFIMRDETAPKG--YKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIV 504
            ::.|:.:.|:.|     .||  .:|:|||:::.|:..:.|.|.:..|:||::|..|::|.|||::
Zfish    26 KVTTIKEEPYAM-----SKGSELEGFCIDMLSAISNKLGFKYDVHLVKDGRYGKTDDSGNWNGMI 85

  Fly   505 KKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRP--SSPSSLFKFLTVLETNVWL 567
            .:::..:|||.:..:::.|:||.|:|.:.|:.. .|::.:|::.  |..|.....|.:..|.:|:
Zfish    86 GEVVRGEADIAVAPLTLTAQREAVVDMSKPFMQ-TGLSFIMRKDLGSDDSQFLSLLKLFSTEMWM 149

  Fly   568 CILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLWFCMTSLTPQGGGEAPKNL 632
            .:|.||..||..:::..|.||..::      :.:::...|.|....|:.:.:||.||.|..||.|
Zfish   150 GVLVAYLLTSICIFLVSRISPCEWE------QPEKDNNSFTLSHSFWYTVGALTLQGAGPHPKAL 208

  Fly   633 SGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFER 697
            |||::.:.||:|..:::|.|.|||:.:|........:::.:|||.|..|.|..:..||:..:|:.
Zfish   209 SGRVITSIWWIFSLVLLACYFANLSLWLHSDNQQLSIKTFEDLANQNVIEYGTIKDSSSFNFFKN 273

  Fly   698 MSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAVARVRN 762
            .:|                                  ..|.::::.::|           |:..:
Zfish   274 SNN----------------------------------PTYHRIYEHIKE-----------AQSYS 293

  Fly   763 STAATGF--------AFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAIL 819
            ..||.||        ||:|::..:.......|:|....|....:.|:||...||.|....:.|||
Zfish   294 LNAAEGFRRAQKGNYAFIGESVSLDLAVARYCNLTRAPEIIGMRGYSIAAPLGSPLIKNLSVAIL 358

  Fly   820 TLLNKRQLEKLKEKWWKNDEALAKCDKPEDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWY 884
            .|....:|:..:.|||     .:.|...:.:...:...::.|||:::..|:|:.....:.|.
Zfish   359 RLSESGELDYFRSKWW-----ASSCVAKDSKGAPLKPASLKGVFLLLAFGLGLGIFLALMEL--- 415

  Fly   885 RYRKNPRIIDVAEANAERSN-----AADHPGKLVDGVILGHSGEKFEKSKA 930
             ..|:.::     ||:|:.:     :|:...:...|.:.  :.|..||:||
Zfish   416 -AAKSRKV-----ANSEQKSCCSVMSAELSQRFRGGEVA--TPESSEKNKA 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378
		PBP2_iGluR_putative	438..836	CDD:270435	104/405 (26%)
		Lig_chan	565..870	CDD:278489	73/312 (23%)
si:ch211-251b21.1	NP_001138274.1	PBP2_iGluR_non_NMDA_like	25..375	CDD:270403	105/410 (26%)
si:ch211-251b21.1	NP_001138274.1	Lig_chan	146..396	CDD:278489	70/305 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810