Protein Alignment Ir25a and grin2ab

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_073805448.1
• Gene: grin2ab / 570493
• ZFINID: ZDB-GENE-070424-223
• Length: 1445
• Species: Danio rerio
• Alignment Length: 957
• Identity: 210/957 - (21%)
• Similarity: 368/957 - (38%)
• Gaps: 251/957 - (26%)

  Fly    42 NEVDNEPAAKAVEVVL----TYLKKNIR--YGLSVQLD----SIEANKSDAKVLLEAICNKYATS 96
            ::...:|.:.::.|:|    |..:..:|  .|:...||    ||:.|::|...:|..:|     .
Zfish    18 SQAAEKPPSLSIAVILGQTPTVSESALRPARGIGAPLDVTVLSIQVNQTDPGSMLTHLC-----E 77

  Fly    97 IEKKQTPHLIL--DTTKSGIASETVKSFTQALGLPTI---------------SASYGQQGDLRQW 144
            :..:|..|.::  |.|.....::.:...:....:|.:               |:|:.|.|...|.
Zfish    78 LMSRQRLHGLVYGDGTDQEAVAQMLDFVSSQTSMPILGIHGGSAMTMAEKDSSSSFFQFGASLQQ 142

  Fly   145 RDLDEAKQKYLLQVMPPADIIPEAIRSIV------IHMNITNAAILYDDSFVM------------ 191
            ..|      .:|.:|...|   ..:.|:|      ....|....:..|.|||.
Zfish   143 EAL------LMLAIMEEYD---WHVFSVVTTKFPGFQEFIATVRVTVDHSFVRWDLQSVVTLDGV 198

  Fly   192 ---DHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSIRM-VLESVKP 252
               :.:....|:.||:..::...:||   |....:|:.|:|.:.....:..:.|:.. .||.:..
Zfish   199 GEPEDRAHVQLKRIQSPVILLYCSKD---EAALVMEEARSLGLTGAGFVWIVPSLTTGNLEHIPE 260

  Fly   253 AYFERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTT---------------- 301
            |:            ..|.||...|.    :..|:. |:.:|.:|::.:.
Zfish   261 AF------------PAGMISVTYDE----WDYPLE-TRLQDAVGIISSAAAAMFREEGRIPDGTA 308

  Fly   302 --YNLNEEPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGG--------NTPQ-- 354
              |..:|:|::..:     |||.:     |:......||..::: |.:|..        ||.:
Zfish   309 SCYGQSEKPEVPPS-----ALRRY-----MMGVNLGGKDHSFMD-DGYQVNPKLVVIVLNTEREW 362

  Fly   355 ------RNLDLRDYFTKITEPTSYGTFD-------LVTQSTQPFNGHSFMKFEMDINVLQIRGGS 406
                  .|..||..|.......|:|..|       :||...:||    .:..::||    :.|..
Zfish   363 EKMGRWENHSLRLKFPVWPRYNSFGDMDADENHLSIVTLEERPF----VIVDDVDI----LTGTC 419

  Fly   407 SVNSKSIGKWISGLNSELIVKDEEQMKNLTADTVYRIFTVVQAPFIMRDETAPKGYKGYCIDLIN 471
            ..||               |...:.:|:.|.:..|                ..|..||:|||::.
Zfish   420 MRNS---------------VPCRKHIKDNTTEGSY----------------VKKCCKGFCIDILK 453

  Fly   472 EIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYY 536
            :||..|.|.|.:..|.:||.|. ..|..|||:|.:::.|:|.:.:||:::..||...|||:||:.
Zfish   454 KIARNVKFTYDLYLVTNGKHGK-KINNVWNGMVGEVVYKKAVMAVGSLTINEERSEAIDFSVPFV 517

  Fly   537 DLVGITIMMQRPSSPSSLFKFLTVLETNVWLCILAAYFF-TSFLMWIFDRWSPYSYQNNREKYKD 600
            : .||::|:.|.:...|...||.....:||:.:...... |:..:::|:..||..:..|..:.||
Zfish   518 E-TGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVTAIAVFLFEFISPLGFNRNLAQGKD 581

  Fly   601 DEEKREFNLKECLWFCM-----TSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFL 660
            .... .|.:.:.:|...     .|:..|.    |:..:.:.:.:.|..|..|.:||||||||||:
Zfish   582 PHGP-SFTIGKAVWLLWGLVFNNSVPVQN----PRGTTSKFIVSVWAFFAVIFLASYTANLAAFM 641

  Fly   661 TVSRLDTPVESLDDLAKQYKILYAP-------LNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSL 718
            ........|..|.|...|....|:|       .|||:
Zfish   642 IQEEFVDQVTGLSDRKFQSPYSYSPPFRFGTVPNGST---------------------------- 678

  Fly   719 TAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAVARVRNSTAATG--FAFLGDATDIRYL 781
               ||:        :...|..|.|.|.:......:|..|      :..||  .||:.||..:.|:
Zfish   679 ---ERN--------IRKNYPAMHQYMVKYHQTGVVDALV------SLKTGKLDAFIYDAAVLNYM 726

  Fly   782 --QLTNCDLQVVGEE--FSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALA 842
              :...|.|..:|..  |:...|.||:|:||:.|...:.|||.::...::|:|:.:|.   ..:.
Zfish   727 AGRDDGCKLVTIGSGYIFATTGYGIAMQKGSYWKRLVDLAILGIIGDGEMEELEAQWL---TGIC 788

  Fly   843 KCDKPEDQSDGISIQNIGGVFIVIFVGIGMACITLVFE---YWWYRY 886
            ..:|.|..|..:.:.|:.|||.::...:.::.||.|:|   ||..||
Zfish   789 HNEKNEVMSSQLDVDNMAGVFYMLAAAMALSLITFVWEHLFYWRLRY 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	85/465 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	107/416 (26%)
grin2ab	XP_073805448.1	None