DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and grin3a

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	XP_009303361.1	Gene:	grin3a / 564832	ZFINID:	ZDB-GENE-130530-780	Length:	1111	Species:	Danio rerio

Alignment Length:	967	Identity:	191/967 - (19%)
Similarity:	355/967 - (36%)	Gaps:	251/967 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MILMNPKTSKILWLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIR 65
            |.:.||:||:...:...||:.:.|.:.:......||:..               |.|.:......
Zfish   245 MAMQNPQTSQANLIFSLLSMNNWFDVSLVMCQQMNISDF---------------VFLLHNNSKFH 294

  Fly    66 YGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKSFTQALGLPT 130
            .|..:::.:..::|:|..:.|:|                          ..|::|..|..|
Zfish   295 LGTVLKISTNSSSKNDFHIFLQA--------------------------QLESIKDSTSTL---- 329

  Fly   131 ISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADII------PEAIRSIVIHMNITNAAILYDDSF 189
              .::|  .|:|..|.:.....|:.| ::|....|      .|.:|:..:.|.:.....:.:.|
Zfish   330 --VTFG--CDIRDIRRIFTTIAKFGL-ILPDYHWIIGDSQNVEELRTEGLPMGLLAHGRMGEPS- 388

  Fly   190 VMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSI-RMVLESVKPA 253
             :||..:..|:       :.|.|.........|:.          .|.||...: |:..:::...
Zfish   389 -LDHYVQDALE-------LVARAVGSAATVSPQLA----------LIPGTTNCLARLEAKNLTSG 435

  Fly   254 YF-ERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTTYNLNEEPQLSSAFYFD 317
            .| .|..|..:.....|.||.|.::..|.......:....|.:|          :|..:
Zfish   436 TFLSRYMASTSFDGLSGCISVQEESTIISESHHFIWNLQHDPIG----------KPMWT------ 484

  Fly   318 LALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQST 382
             .|.|:...|.::..|.||.........|::..:    .|.||                :||...
Zfish   485 -RLGSWKHGKVVMDYGVWPNKRRSQPGADWRHSS----RLHLR----------------VVTLVE 528

  Fly   383 QPFNGHSFMKFEMDINVLQIRGGSSVNSKSIGKWISGLNSELIVKDEEQMKNLTADT--VYRIFT 445
            .||      .|..|::                      :..|....:..:..||.||  :..:|.
Zfish   529 HPF------VFTRDVD----------------------DEGLCPAGQLCLDPLTNDTALLESLFQ 565

  Fly   446 VVQAPFIMRDETAPKGYK----GYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKK 506
            .:|.    .::|.|..:|    ||||||:.::|..:.||:.:..|.|||:|.. :||:|.|:|..
Zfish   566 GLQG----ANDTVPLEFKKCCYGYCIDLLEKLAEDMGFDFDLYIVGDGKYGAY-KNGRWTGLVGD 625

  Fly   507 LMDKQADIGLGSMSVMAEREIVIDFTVPYYDL-VGITIMMQRPSSPSSLFKFLTVLETNVWLCIL 570
            ||...|.:.:.|.|:.:.|..|||||.|::.. :||.:..:..::|  :..|:..|..::||.|.
Zfish   626 LMSGAAHLAVTSFSINSARSQVIDFTSPFFSTSLGILVRTRDTAAP--IGAFMWPLHWSMWLGIF 688

  Fly   571 AAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLWFCMTSLTPQGGG-EAPKNLSG 634
            .:...|:..:.:::..||:. ...|.:.:|    |.|:....|..|...|..:... :.||..:|
Zfish   689 VSLHVTAVFLTLYEWKSPFG-MTPRGRNRD----RVFSFSSALNVCYAILFGRTAAIKPPKCWTG 748

  Fly   635 RLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMS 699
            |.:...|.:|....:::|||||||.:...:....:..:.|     ..|:.|..|.       |..
Zfish   749 RFLMNLWAIFCLFCLSTYTANLAAVMVGEKTYEQLSGIHD-----PKLHHPSQGF-------RFG 801

  Fly   700 NIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAVARVRNST 764
            .:.:...|                      || |...:.:|.:.|:....|.|.| .:..:::..
Zfish   802 TVRESSAE----------------------DY-VKKSFPEMHEYMRRYNAPTTPD-GIDHLKDDP 842

  Fly   765 AATGFAFLGDATDIRY----------LQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAIL 819
            .... ||:.|...:.|          |.||.              |.|.::|.|.|....:..:.
Zfish   843 QKLD-AFIMDKALLDYWAHADKXYISLLLTG--------------YGIGLKQNSPLTSNISELVS 892

  Fly   820 TLLNKRQLEKLKEKWWKNDEALAKCDKPE---DQSDGISIQNIGGVFIVIFVGIGMACITLVFEY 881
            ...:...::.|.:||:|    :..|.|..   .::..:.|::..|:|:::.||:.::.:|.:.|:
Zfish   893 QYKSDGFMDMLHDKWYK----VVPCGKRSFAVTETLQMGIKHFSGLFVMLCVGVALSLLTTLGEH 953

  Fly   882 WWYRYRKNPRIIDVAEANAERSNAADHPGKLVDGVILGHSGEKFEKSKAALRPRFNQ 938
            ..:|: ..||:          ..:.:|...|       |:.::..:   ||.|.|.:
Zfish   954 IVHRW-VIPRM----------QESTEHKYWL-------HTSQRLHR---ALNPTFKE 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	61/393 (16%)
		PBP2_iGluR_putative	438..836	CDD:270435	98/415 (24%)
		Lig_chan	565..870	CDD:278489	62/318 (19%)
grin3a	XP_009303361.1	Periplasmic_Binding_Protein_Type_1	36..502	CDD:299141	58/342 (17%)
		ANF_receptor	132..452	CDD:279440	46/275 (17%)
		PBP2_iGluR_NMDA_Nr3	518..908	CDD:270438	109/496 (22%)
		Lig_chan	682..941	CDD:278489	61/318 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591834
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740