Protein Alignment Ir25a and grin2aa

DIOPT Version :9

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_021329529.1
• Gene: grin2aa / 563297
• ZFINID: ZDB-GENE-070424-129
• Length: 1460
• Species: Danio rerio
• Alignment Length: 1002
• Identity: 213/1002 - (21%)
• Similarity: 377/1002 - (37%)
• Gaps: 295/1002 - (29%)

  Fly    12 LWLLGFLSLLSSFSLEIAAQTTQNINVL-------FINEVD-------NEPAAKAVEVVLTYLKK 62
            |.||...:||:..|:..||:....:|:.       :|::.|       ::|
Zfish    11 LVLLTLPALLTLISISHAAEKVPILNIAVILGQTRYISDRDIRALWSKDDP-------------- 61

  Fly    63 NIRYGLSVQLDSIEANKSDAKVLLEAICNKYA-TSIEKKQTPHLIL---DTTKSGIASETVKSFT 123
                 :.|.:.::..|::|.|.::..:|:..: |.|      |.::   .|.:..||.  :..|.
Zfish    62 -----IDVNVVTLLVNETDPKSIITHVCDLMSGTKI------HGVVFGDGTDQEAIAQ--ILDFI 113

  Fly   124 QALGLPTISASYGQQGDLRQWRDLDEA--------KQKYLLQVMPPADIIPE---AIRSIV---- 173
            .:..|..|...:|....:...:|:...        :|:.||.:    :|:.|   .:.|||
Zfish   114 SSQTLIPILGIHGGSSMIMADKDVKSTFFQFGASIQQEALLML----NIMEEYDWHVFSIVTSKF 174

  Fly   174 ---------IHMNITNAAILYD-------DSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQ 222
                     :...:.|:.:.:|       |:...|.:.:..|:.:|:..|:...:||   |....
Zfish   175 PGYQDFIAILKTTVDNSFVGWDLQHIITLDAVDGDSRTQIQLKKVQSPVVLLYCSKD---EAAYI 236

  Fly   223 IEKLRNLDINNFFILGTLQSIRMVLESVKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMA 287
            :|:.|:|.:..|..:..:.|:......:.|..|.           .|.||...|:    :..|:.
Zfish   237 LEEARSLGLTGFGYIWIVPSLTTGNPEITPDTFP-----------SGMISVSYDD----WDYPLE 286

  Fly   288 YTQYRDRLGLLRTT-----YNLNEEPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDF 347
             .:.||.||::.|.     ....:.|:..::.|..:.       |..|...|
Zfish   287 -ARVRDGLGIITTAAAAMLEEFGDIPEAKTSCYGQME-------KTKLPPSA------------- 330

  Fly   348 QGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRGGSSVNSK- 411
                       |..|...:|                 ::|.. :.|..|        |..|:.|
Zfish   331 -----------LHKYMMNVT-----------------WDGKD-LSFTED--------GYQVHPKL 358

  Fly   412 ------------SIGKWISGLNSELIVK-----------DEEQMKNLTADTVYRIFTVVQAPFI- 452
                        .:|||   .|..|.:|           |.|     |.|....|.|:.:.||:
Zfish   359 VVIVLNKDREWEKMGKW---ENQSLTLKYPVWPRFNSFGDAE-----TDDNHLTIVTLEEKPFVI 415

  Fly   453 ---------------------MRDETAPKG-------YKGYCIDLINEIAAIVHFDYTIQEVEDG 489
                                 ::|.|...|       .||:|||::.:||..|.|.|.:..|.:|
Zfish   416 VENVERLTGTCMRNSVPCRKHIKDNTTEGGGTYIKKCCKGFCIDILKKIARNVKFTYDLYLVTNG 480

  Fly   490 KFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPSSL 554
            |.|. ..|..|||:|.::::|:|.:.:||:::..||..||||:||:.: .||::|:.|.:...|.
Zfish   481 KHGK-KINNVWNGMVGEVVNKKAVMAVGSLTINEERSEVIDFSVPFVE-TGISVMVSRSNGTVSP 543

  Fly   555 FKFLTVLETNVWLCILAAYFF-TSFLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLWFCM- 617
            ..||.....:||:.:...... |:..:::|:..||..:..|..:.||.... .|.:.:.:|...
Zfish   544 SAFLEPFSASVWVMMFVMLLLVTAMAVFMFEYISPLGFNRNLAQGKDPHGP-SFTMGKAVWLLWG 607

  Fly   618 ----TSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQ 678
                .|:..|.    ||..:.:.:.:.|..|..|.:||||||||||:........|..|.|...|
Zfish   608 LVFNNSVPVQN----PKGTTSKFIVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQ 668

  Fly   679 YKILYAP-------LNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDK 736
            ....|:|       .|||:.....:...::.|...: :....:||:|.:::..||.
Zfish   669 SPYSYSPPFRFGTVPNGSTERNIRKNYPDMHQYMVK-YHQTGVNDALVSLKTGKLD--------- 723

  Fly   737 YTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGDATDIRYL--QLTNCDLQVVGEE--FSR 797
                                             ||:.||..:.|:  :...|.|..:|..  |:.
Zfish   724 ---------------------------------AFIYDAAVLNYMAGRDEGCKLVTIGSGYIFAT 755

  Fly   798 KPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQSDGISIQNIGGV 862
            ..|.||:|:||..|...:.|||.::...::|:|:.:|.   ..:...:|.|..|..:.:.|:.||
Zfish   756 TGYGIALQKGSLWKRPVDLAILAIIGDGEMEELEAQWL---TGICHNEKNEVMSSQLDVDNMAGV 817

  Fly   863 FIVIFVGIGMACITLVFE---YWWYRY 886
            |.::...:|::.||.|:|   ||..||
Zfish   818 FYMLATAMGLSLITFVWEHLFYWRLRY 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	73/445 (16%)
		PBP2_iGluR_putative	438..836	CDD:270435	111/443 (25%)
		Lig_chan	565..870	CDD:278489	72/321 (22%)
grin2aa	XP_021329529.1	PBP1_iGluR_NMDA_NR2	33..389	CDD:107373	75/465 (16%)
		PBP2_iGluR_NMDA_Nr2	400..799	CDD:270436	111/451 (25%)
		NMDAR2_C	836..1460	CDD:313729	4/9 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591469
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740