Protein Alignment Ir25a and grik1b

DIOPT Version :9

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_690040.5
• Gene: grik1b / 561540
• ZFINID: ZDB-GENE-070821-1
• Length: 906
• Species: Danio rerio
• Alignment Length: 988
• Identity: 246/988 - (24%)
• Similarity: 422/988 - (42%)
• Gaps: 226/988 - (22%)

  Fly    15 LGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAA---KAVEVVLTYLKKN--------IRYGL 68
            :.|:.|.....:.::||....|..:| ..::|||.:   .|.:..:|.:.:|        :.|.:
Zfish    45 VSFILLCLMAEVGLSAQQVLRIGGIF-ETLENEPISVEELAFKFAVTNINRNRTLMPNTTLTYDI 108

  Fly    69 S-VQL-DSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKSFTQALGLPTI 131
            . :.| ||.||::        ..|::.|..:.....|     :..|.:::  |:|...||.:|.|
Zfish   109 QRINLFDSFEASR--------RACDQLALGVAAVFGP-----SHSSSVSA--VQSICNALEVPHI 158

  Fly   132 SASYGQQGDLRQWR--DLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDHK 194
            ..         :|:  .:|. |..:.:.:.|....|..|:..||.........::|:|:..:
Zfish   159 QT---------RWKHPSVDN-KDSFYINLYPDYASISRAVLDIVQFYKWKAVTVVYEDATGL--- 210

  Fly   195 YKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSIRMVLESVKP-----AY 254
                   |:.:.:|.|.::...:      .|:|.|...:       :..|.:|:.:|.     ..
Zfish   211 -------IRLQELIKAPSRYSIK------IKIRQLPTGS-------KDARPLLKEMKKGKEFCVI 255

  Fly   255 FERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTTYNLNEEPQLSSAFYFDLA 319
            |:.::      |...::..|     ::.|            |::...|:.         |:..|.
Zfish   256 FDCSY------QTAADVLKQ-----LLSM------------GMMTEYYHF---------FFTTLD 288

  Fly   320 LRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNT------------PQRNLDLRDYFTKITEPTSY 372
            |.| |.::....||........||.|:.|..:.            |:....|:|..........|
Zfish   289 LYS-LDLEPFRYSGVNMTGFRLLNIDNPQVASVVEKWSMERLQAPPKPETGLQDGMMTTEAALMY 352

  Fly   373 GTFDLVTQSTQ----------------PFN-GHSFMK-------------------------FEM 395
            ....:|..::|                |:. |..|:.                         |::
Zfish   353 DAVYMVAAASQRASQITVSSLQCHRHKPWRFGSRFISMFKEAQWNGLTGQIIINKTDGLRKDFDL 417

  Fly   396 DINVLQIRG------GSSVNS--KSIGKWISGLNSELIVKDEEQMKNLT---ADTVYRIFTVVQA 449
            ||..|:..|      ....|.  |.||.|.|.....|...::::..|:|   |:....:.|:::.
Zfish   418 DIISLKEDGLEKPLESGRFNKVWKKIGVWNSNTGLNLTDSNKDKNTNVTDSMANRTLIVTTILEN 482

  Fly   450 PFIMRDETAPKGY-----KGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMD 509
            |::|..::....|     :|||:||:.|::.|:.|.|.::.|.|||:|..::.|:|||:|::|:|
Zfish   483 PYVMYKKSDKPLYGNDRFEGYCLDLLKELSNILGFSYEVKLVTDGKYGAQNDKGEWNGMVRELID 547

  Fly   510 KQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPS-SLFKFLTVLETNVWLCILAAY 573
            ..||:.:..:::...||.||||:.|:..| ||:|:..:|:..: .:|.||..|..::|:.:|.|.
Zfish   548 HVADLAVAPLTITYVREKVIDFSKPFMTL-GISILYHKPNGTNPGVFSFLNPLSPDIWMYVLLAC 611

  Fly   574 FFTSFLMWIFDRWSPYSYQNNREKYKD-DEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLV 637
            ...|.::::..|::||.:.|......| |..:..|.|...:||.:.:|..||....||.||.|:|
Zfish   612 LGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLINSVWFGVGALMQQGSELMPKALSTRIV 676

  Fly   638 AATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIE 702
            ...||.|..|||:||||||||||||.|:|:|::|.||||||.||.|..:...|.||:|
Zfish   677 GGIWWFFTLIIISSYTANLAAFLTVERMDSPIDSADDLAKQTKIEYGAVRDGSTMTFF------- 734

  Fly   703 QMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATLD---EAVARVRNST 764
                               ::||::.        |.|||..|...|..|.:.   |.:.||
Zfish   735 -------------------KKSKIST--------YEKMWAFMSSRKNTALVKNNREGIQRV---- 768

  Fly   765 AATGFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEK 829
            ..|.:|.|.::|.|.|:...||:|..:|.....|.|.:....||..:|:...|||.|..:.:|..
Zfish   769 LTTDYALLMESTSIEYISQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKVTIAILQLQEEGKLHM 833

  Fly   830 LKEKWWKNDEALAKCDKPEDQS---DGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPR 891
            :|||||:.:..      ||:.|   ..:.::||||:|||:..|:.::....:.|: .|:.|||..
Zfish   834 MKEKWWRGNGC------PEEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEF-IYKSRKNLD 891

  Fly   892 IIDVAEANAERSN 904
            |.:|:....|..|
Zfish   892 IEEVSVGQCEWHN 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	80/467 (17%)
		PBP2_iGluR_putative	438..836	CDD:270435	137/407 (34%)
		Lig_chan	565..870	CDD:278489	105/311 (34%)
grik1b	XP_690040.5	Periplasmic_Binding_Protein_Type_1	62..455	CDD:299141	80/474 (17%)
		ANF_receptor	80..423	CDD:279440	67/423 (16%)
		Periplasmic_Binding_Protein_Type_2	471..840	CDD:304360	137/407 (34%)
		Lig_chan	602..871	CDD:278489	105/312 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591613
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840