DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir25a and grik4

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	XP_021322087.1	Gene:	grik4 / 556582	ZFINID:	ZDB-GENE-070821-5	Length:	965	Species:	Danio rerio

Alignment Length:	811	Identity:	223/811 - (27%)
Similarity:	365/811 - (45%)	Gaps:	160/811 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 IRSIVIHMNITNAAILYDDS--------FVMDHKYKSLL--QNIQTRHVITAIAKDGKREREEQI 223
            :|..:|.....:..:| |||        .:.|.|..:::  .|....|||.           |:.
Zfish   179 LRQFLISKETLSVRML-DDSQDPTPLLKEIRDDKTATIIVDANATMSHVIL-----------ERA 231

  Fly   224 EKLRNLDINNFFILGTLQSIRMVLESVKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMAY 288
            .:|..|.:...:||.:|:...:.|:                     :::.||.|.....:....:
Zfish   232 SELGMLSVYYTYILTSLEFSLLRLD---------------------DLADQRVNIVGFSVFNRTH 275

  Fly   289 TQYRDRLGLLRTTY--NLNEEP----QLSSAFYFDLALRSFLTIKEMLQS---GAWPKDMEYLNC 344
            ..::|.:..|..::  |.:..|    .||||..||........::|:.:|   ||     ..|:|
Zfish   276 PFFQDFVLSLNRSWQENCDHAPFAGTPLSSALLFDAVHTVVAAVQELNRSQNVGA-----TQLSC 335

  Fly   345 DDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRGGSSVN 409
               :.....:....|.:|...:......|..:        ||.    |.:.....|:|...|...
Zfish   336 ---KSSKIWEHGTSLMNYLRMVELEGLTGHIE--------FNS----KGQRSNYALRIMQNSRDG 385

  Fly   410 SKSIGKWISGLNSELIVKDEEQMKNL-TADTVYR----IFTVVQAPFIM-----RDETAPKGYKG 464
            .:.||:|    :||..:..|.::.:| ..||::.    |.|:::.|::|     ::......|:|
Zfish   386 LRQIGQW----HSEQGLSMERKLPSLNVTDTLFNTTLTITTILENPYVMLRANHQELEGNDRYEG 446

  Fly   465 YCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVI 529
            :|:|::.|:|.|:.|.|.|:.|.||.:|....||.|.|:|.:|:.::||:.:.::::.||||.||
Zfish   447 FCVDMLKELADILKFKYRIRLVGDGVYGVPGANGTWTGMVGELISRKADLAVAALTITAEREKVI 511

  Fly   530 DFTVPYYDLVGITIMM-----QRPSSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPY 589
            ||:.|:..| ||:||.     :||    ..|.||......|||.:|.||...|.::::..|.:||
Zfish   512 DFSKPFMTL-GISIMYRVHIGRRP----GYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPY 571

  Fly   590 SYQNNRE--KYKDDEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASY 652
            .:.|...  |.:......:::|....||.:.....||...||:.||.|.|:..||.|..|||:||
Zfish   572 EWYNPHPCLKGRCSLLINQYSLGNSFWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSY 636

  Fly   653 TANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDS 717
            ||||||||||.|::.|:||:||||.|..|.|..::|.|.||:|:...      |:
Zfish   637 TANLAAFLTVQRMEVPIESVDDLADQTAIEYGTMHGGSTMTFFQNSR------YQ---------- 685

  Fly   718 LTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPA----TLDEAVARVRNSTAATGFAFLGDATDI 778
                              .|.:||..|. :|.|:    :.:|.:|||.||    .:|:|.::|..
Zfish   686 ------------------TYQRMWNFMY-SKQPSVFVKSTEEGIARVLNS----NYAYLLESTMN 727

  Fly   779 RYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAK 843
            .|.:..||:|..:|.....|.|.|.:..||..:|:|:.|||.|..:.:||.||.|||..    .|
Zfish   728 EYYRQRNCNLTQIGGLLDTKGYGIGMPLGSVYRDEFDLAILRLQEENRLEILKRKWWDG----GK 788

  Fly   844 CDKPED-QSDGISIQNIGGVFIVIFVGIGMACITLVFEY-WWYRYRKNPRIIDVAEANAERSNAA 906
            |.|.|| ::.|:.::||||:|:|:..|:.:|....|.|: |..|:.....:....|...|
Zfish   789 CPKEEDHRAKGLGMENIGGIFVVLVCGLLVAIFMAVLEFVWMLRHTPGTELSVCEEMLRE----- 848

  Fly   907 DHPGKLVDGVILGHSGEKFEKSKAA--LRPR 935
                  :.|::|.....:..:.:.|  |||:
Zfish   849 ------LQGIVLCQDSLQLRRRRGASVLRPQ 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	52/275 (19%)
		PBP2_iGluR_putative	438..836	CDD:270435	142/417 (34%)
		Lig_chan	565..870	CDD:278489	108/311 (35%)
grik4	XP_021322087.1	Periplasmic_Binding_Protein_Type_1	26..400	CDD:324556	52/277 (19%)
grik4	XP_021322087.1	PBP2_iGluR_kainate_KA1	425..785	CDD:270442	138/403 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590984
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840