Protein Alignment Ir25a and grik2

DIOPT Version :9

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_021322472.1
• Gene: grik2 / 556013
• ZFINID: ZDB-GENE-080414-1
• Length: 908
• Species: Danio rerio
• Alignment Length: 927
• Identity: 236/927 - (25%)
• Similarity: 403/927 - (43%)
• Gaps: 224/927 - (24%)

  Fly    73 DSIEANKSDAKVLLEAICNKYA-TSIEKKQT--PHLIL--------------------DTTKSGI 114
            :|||:..|.|    |.:..|:| .:|.:.:|  |:..|                    |....|:
Zfish    43 ESIESGPSGA----EELAFKFALNTINRNRTLLPNTTLTYDIQRINIHDSFEASRKACDQLSLGV 103

  Fly   115 A----------SETVKSFTQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAI 169
            |          :..|:|...|||:|.|...:..|        :.:.:..:.:.:.|....:..||
Zfish   104 AAIFGPSHSSSANAVQSICNALGVPHIQTKWKHQ--------VSDNRDSFYVNLYPDFSSLSRAI 160

  Fly   170 RSIVIHMNITNAAILYDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNF 234
            ..:|.........::||||..:          |:.:.:|.|.::...|      .|:|.|..:.
Zfish   161 LDLVHFFKWKTVTVVYDDSTGL----------IRLQELIKAPSRYNIR------LKIRQLPADT- 208

  Fly   235 FILGTLQSIRMVLESVKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLR 299
                  :..:.:|:.:|     |...:|.|      .....:.|..:..:.:|       :|::.
Zfish   209 ------KDAKPLLKEMK-----RGKEFHVI------FDCGHEMAAGILKQALA-------MGMMT 249

  Fly   300 TTYNLNEEPQLSSAFYFDLALRSF-LTIKEMLQSGAWPKDMEYLNCDDFQGGN------------ 351
            ..|:           |....|..| |.::....||........||.::.|..:
Zfish   250 EYYH-----------YIFTTLDLFALDVEPYRYSGVNMTGFRILNTENSQVSSIIEKWSMERLQA 303

  Fly   352 TPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQP-------------------------------- 384
            .|:.:..|.|.|........|....:|..:.|.
Zfish   304 PPKPDSGLLDGFMTTDAALMYDAVHVVAVAVQQSPQITVSSLQCNRHKPWRFGNRFMTLIKEAHW 368

  Fly   385 --------FNGHSFMKFEMDINVLQIRGGSSVNSKSIGKW--ISGLNSELIVKDEEQMKNLTADT 439
                    ||..:.::.:.|::|:.::   ....:.||.|  .||||.      .|..|..||:.
Zfish   369 DGLTGRINFNRTNGLRTDFDLDVISLK---EEGLEKIGTWDPASGLNM------TENQKGKTANV 424

  Fly   440 V-------YRIFTVVQAPFIMRDETAPKGY-----KGYCIDLINEIAAIVHFDYTIQEVEDGKFG 492
            .       ..:.|:::.|::|..::....|     :|||:||:.|:|||:.|.|.::.||||::|
Zfish   425 TDSLSNRSLVVSTILEEPYVMFKKSDKPLYGNDRFEGYCVDLLRELAAILGFGYELRLVEDGRYG 489

  Fly   493 NMDE-NGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPS-SLF 555
            ..|| :|||||:|::|||.:||:.:..:::...||.||||:.|:..| ||:|:.::|:..: .:|
Zfish   490 AQDESSGQWNGMVRELMDHKADLAVAPLAITYVREKVIDFSKPFMTL-GISILYRKPNGTNPGVF 553

  Fly   556 KFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKD-DEEKREFNLKECLWFCMTS 619
            .||..|..::|:.||.||...|.::::..|:|||.:.|......| |..:..|.|....||.:.:
Zfish   554 SFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGA 618

  Fly   620 LTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYA 684
            |..||....||.||.|:|...||.|..|||:||||||||||||.|:::|::|.||||||.||.|.
Zfish   619 LMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYG 683

  Fly   685 PLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAK- 748
            .:...|.||:|                          :::|::.:|        |||:.|...:
Zfish   684 VVEDGSTMTFF--------------------------KKTKISTYD--------KMWEFMSSRRH 714

  Fly   749 --LPATLDEAVARVRNSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLK 811
              :..:::|.:.||..|    .:|||.::|.|.::...||:|..:|.....|.|.:....||..:
Zfish   715 SVMVKSIEEGIERVLTS----DYAFLMESTTIEFVTQRNCNLTQIGGLIDSKAYGVGTPMGSPYR 775

  Fly   812 DQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPED-QSDGISIQNIGGVFIVIFVGIGMACI 875
            |:...|||.|..:.:|..:|||||:.:    .|.:.|: ::..:.:|||||:|||:..|:.::..
Zfish   776 DKITIAILQLQEEGKLHMMKEKWWRGN----GCPEEENKEASALGVQNIGGIFIVLAAGLVLSVF 836

  Fly   876 TLVFEYWWYRYRKNPRI 892
            ..|.|: .|:.::|.::
Zfish   837 VAVGEF-LYKSKQNAQL 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	74/440 (17%)
		PBP2_iGluR_putative	438..836	CDD:270435	142/415 (34%)
		Lig_chan	565..870	CDD:278489	104/309 (34%)
grik2	XP_021322472.1	PBP1_iGluR_Kainate	37..414	CDD:380605	74/443 (17%)
		Periplasmic_Binding_Protein_Type_2	430..800	CDD:419667	142/408 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591881
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840