Protein Alignment Ir25a and Grik2

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_062182.1
• Gene: Grik2 / 54257
• RGDID: 2733
• Length: 908
• Species: Rattus norvegicus
• Alignment Length: 908
• Identity: 236/908 - (25%)
• Similarity: 399/908 - (43%)
• Gaps: 203/908 - (22%)

  Fly    57 LTYLKKNIRYGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKS 121
            |||..:.|..     .||.||:|.        .|::.:..:.      .|...:.|..|: .|:|
  Rat    76 LTYDTQKINL-----YDSFEASKK--------ACDQLSLGVA------AIFGPSHSSSAN-AVQS 120

  Fly   122 FTQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYD 186
            ...|||:|.|...:..|        :.:.|..:.:.:.|....:..||..:|.........::||
  Rat   121 ICNALGVPHIQTRWKHQ--------VSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYD 177

  Fly   187 DSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSIRMVLESVK 251
            ||..:          |:.:.:|.|.::...|      .|:|.|..:.       :..:.:|:.:|
  Rat   178 DSTGL----------IRLQELIKAPSRYNLR------LKIRQLPADT-------KDAKPLLKEMK 219

  Fly   252 PAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTTYNLNEEPQLSSAFYF 316
                 |...:|.|      .....:.|..:..:.:|       :|::...|:           |.
  Rat   220 -----RGKEFHVI------FDCSHEMAAGILKQALA-------MGMMTEYYH-----------YI 255

  Fly   317 DLALRSF-LTIKEMLQSGAWPKDMEYLNCDDFQGGN------------TPQRNLDLRDYFTKITE 368
            ...|..| |.::....||........||.::.|..:            .|:.:..|.|.|.....
  Rat   256 FTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDA 320

  Fly   369 PTSYGTFDLVTQSTQPF----------NGHSFMKF------------------------------ 393
            ...|....:|:.:.|.|          |.|...:|
  Rat   321 ALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRT 385

  Fly   394 EMDINVLQIRGGSSVNSKSIGKW--ISGLNSELIVKDEEQMKNLTADTVYR---IFTVVQAPFIM 453
            :.|::|:.::   ....:.||.|  .||||  :....:.:..|:|.....|   :.|:::.|:::
  Rat   386 DFDLDVISLK---EEGLEKIGTWDPASGLN--MTESQKGKPANITDSLSNRSLIVTTILEEPYVL 445

  Fly   454 RDETAPKGY-----KGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDE-NGQWNGIVKKLMDKQA 512
            ..::....|     :||||||:.|::.|:.|.|.|:.|||||:|..|: ||||||:|::|:|.:|
  Rat   446 FKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKA 510

  Fly   513 DIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPS-SLFKFLTVLETNVWLCILAAYFFT 576
            |:.:..:::...||.||||:.|:..| ||:|:.::|:..: .:|.||..|..::|:.:|.|....
  Rat   511 DLAVAPLAITYVREKVIDFSKPFMTL-GISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGV 574

  Fly   577 SFLMWIFDRWSPYSYQNNREKYKD-DEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAAT 640
            |.::::..|:|||.:.|......| |..:..|.|....||.:.:|..||....||.||.|:|...
  Rat   575 SCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMRQGSELMPKALSTRIVGGI 639

  Fly   641 WWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMF 705
            ||.|..|||:||||||||||||.|:::|::|.||||||.||.|..:...:.||:|
  Rat   640 WWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFF---------- 694

  Fly   706 YEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAM---QEAKLPATLDEAVARVRNSTAAT 767
                            ::||::.:|        |||..|   :::.|..:.:|.:.||..|
  Rat   695 ----------------KKSKISTYD--------KMWAFMSSRRQSVLVKSNEEGIQRVLTS---- 731

  Fly   768 GFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKE 832
            .:|||.::|.|.::...||:|..:|.....|.|.:....||..:|:...|||.|..:.:|..:||
  Rat   732 DYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKE 796

  Fly   833 KWWKNDEALAKCDKPEDQS---DGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRI 892
            |||:.:..      ||::|   ..:.:|||||:|||:..|:.::....|.|: .|:.:||.::
  Rat   797 KWWRGNGC------PEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEF-LYKSKKNAQL 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	71/415 (17%)
		PBP2_iGluR_putative	438..836	CDD:270435	141/411 (34%)
Grik2	NP_062182.1	PBP1_iGluR_Kainate	37..414	CDD:380605	75/422 (18%)
		Periplasmic_Binding_Protein_Type_2	430..800	CDD:473866	141/408 (35%)