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Protein Alignment Ir25a and Gria1

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_113796.1	Gene:	Gria1 / 50592	RGDID:	621531	Length:	907	Species:	Rattus norvegicus

Alignment Length:	989	Identity:	254/989 - (25%)
Similarity:	420/989 - (42%)	Gaps:	275/989 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GFLSLLSSFSLEIAAQTTQNINV--LFINEVDNEPAAKAVEVVLTYLKKNIRYGLS--------- 69
            |||..:      :.|....||.:  ||.|:...|.||             .|:.||
  Rat    11 GFLGAV------VGANFPNNIQIGGLFPNQQSQEHAA-------------FRFALSQLTEPPKLL 56

  Fly    70 VQLDSIEANKSDAKVLLEAICNKYATSI------EKKQTPHLILDTTKSGIASETVKSFTQALGL 128
            .|:|.:  |.||:..:....|::::..:      .:::|.:::             .||..||.:
  Rat    57 PQIDIV--NISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNML-------------TSFCGALHV 106

  Fly   129 PTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDH 193
            ..|:.|:          .:|.:.| ::||:.|.   :.||:.||:.|........:||..
  Rat   107 CFITPSF----------PVDTSNQ-FVLQLRPE---LQEALISIIDHYKWQTFVYIYDAD----- 152

  Fly   194 KYKSLLQNI-----QTRHVITAI-----AKDGKR----EREEQIEKLRNLDINNFFILGTLQSIR 244
            :..|:||.:     :....:||:     .::|.|    :.|::.|:|..:|..:       :.:.
  Rat   153 RGLSVLQRVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCES-------ERLN 210

  Fly   245 MVLESVKPAYFERN-FAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTTYNLNEEP 308
            .:|..:  ...|:| ..:|.|..|.|
  Rat   211 AILGQI--VKLEKNGIGYHYILANLG--------------------------------------- 234

  Fly   309 QLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNTPQ--RNLDLRDYFTKI----T 367
                  :.|:.|..|   ||   |||.....:.:|..|.......|  |..|.||: |::    .
  Rat   235 ------FMDIDLNKF---KE---SGANVTGFQLVNYTDTIPARIMQQWRTSDSRDH-TRVDWKRP 286

  Fly   368 EPTSYGTFDLVTQSTQPFNGHSFMKFEMDIN-------------------------VLQIR---- 403
            :.||..|:|.|....:.|  .|..:..:||:                         :.|:|
  Rat   287 KYTSALTYDGVKVMAEAF--QSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGL 349

  Fly   404 -GGSSVNSK-------------------SIGKW------ISGLNSELIVKDEEQMKNLTADTVYR 442
             |....|.|                   .||.|      :..........|...::|.|    |.
  Rat   350 TGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRT----YI 410

  Fly   443 IFTVVQAPFIMRDETAPK-----GYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMD-ENGQWN 501
            :.|:::.|::|..:.|.:     .|:|||::|..|||..|.:.|.::.|.|||:|..| :...||
  Rat   411 VTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWN 475

  Fly   502 GIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRP-SSPSSLFKFLTVLETNV 565
            |:|.:|:..:||:.:..:::...||.||||:.|:..| ||:||:::| .|...:|.||..|...:
  Rat   476 GMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSL-GISIMIKKPQKSKPGVFSFLDPLAYEI 539

  Fly   566 WLCILAAYFFTSFLMWIFDRWSPYSYQNNR-EKYKD---DEEKREFNLKECLWFCMTSLTPQGGG 626
            |:||:.||...|.::::..|:|||.:.:.. |:.:|   .::..||.:...|||.:.:...||..
  Rat   540 WMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCD 604

  Fly   627 EAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSA 691
            .:|::||||:|...||.|..|||:||||||||||||.|:.:|:||.:|||||.:|.|..|...|.
  Rat   605 ISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGST 669

  Fly   692 MTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPA----T 752
            ..:|                          .|||:||::        |||..|:.|: |:    |
  Rat   670 KEFF--------------------------RRSKIAVFE--------KMWTYMKSAE-PSVFVRT 699

  Fly   753 LDEAVARVRNSTAATGFAFLGDATDIRYL-QLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNN 816
            .:|.:.|||.|...  :|:|.::|...|: |...||...||.....|.|.||..:||.|::..|.
  Rat   700 TEEGMIRVRKSKGK--YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNL 762

  Fly   817 AILTLLNKRQLEKLKEKWWKNDEALAKCDK----PEDQSDGISIQNIGGVFIVIFVGIGMACITL 877
            |:|.|..:..|:|||.|||.:.   .:|..    .:|::..:|:.|:.|||.::..|:|:|.:..
  Rat   763 AVLKLNEQGLLDKLKNKWWYDK---GECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVA 824

  Fly   878 VFEYWWYRYRKNPR 891
            :.|: .|:.|...:
  Rat   825 LIEF-CYKSRSESK 837

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.