Protein Alignment Ir25a and KaiR1D

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_061498559.1
• Gene: KaiR1D / 4576020
• VectorBaseID: AGAMI1_006981
• Length: 930
• Species: Anopheles gambiae
• Alignment Length: 995
• Identity: 259/995 - (26%)
• Similarity: 439/995 - (44%)
• Gaps: 186/995 - (18%)

  Fly    36 INVLFINEVDNEPAAKAVEVVLTYLKKNI--------RYGLSVQLDSIEANKSDAKVLLEAICNK 92
            |..||..:.|::      |:...|..:.|        |..|..|::.|  :..|:.:..:.:|:.
Mosquito    35 IGGLFHPDDDHQ------EIAFRYAVEKINSDRTILPRSKLLAQIERI--SPQDSFLASKRVCHL 91

  Fly    93 YATSIEKKQTPHLILDTTKSGIASETVKSFTQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQ 157
            ....:.      .|.....|..||. |:|....:.:|.:..         :| |....::..|:.
Mosquito    92 LGVGVA------AIFGPQSSHTASH-VQSICDTMEIPHLET---------RW-DYRLRRESCLVN 139

  Fly   158 VMPPADIIPEAIRSIVIHMNITNAAILYD--------DSFVMDH----------------KYKSL 198
            :.|....:.:|...:|......:..|:|:        ...:..|                .|:.|
Mosquito   140 LYPHPSTLSKAYVDLVAAWGWKSFTIIYETNEGLVRMQELLKAHGLSDYPITVRQLSDSGDYRPL 204

  Fly   199 LQNIQT---RHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSIRMVLESVKPAYFERNF- 259
            |:.|:.   .|::...:.:...|..:|.:::..:...:.:::.:|....:.|:..|  |...|.
Mosquito   205 LKQIKNSAESHIVLDCSTERIYEVLKQAQQIGMMSDYHSYLITSLDLHTINLDEFK--YGGTNIT 267

  Fly   260 AWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGL---LRTTYNLNEEPQLSSAFY-----F 316
            |:..:.....|::....|.||          ...|||.   .:|..|:......::..|     |
Mosquito   268 AFRLVDPENPEVAQAIHNWTI----------GEARLGKKVDFKTAENVTVIKAETALMYDAVHLF 322

  Fly   317 DLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQS 381
            ..||....|.:::        |:..|:||.   .:|......|.:|. ||.|  ..|..|::...
Mosquito   323 AKALHDLDTSQQI--------DIHPLSCDT---QDTWPHGYSLINYM-KIVE--MRGLTDVIKFD 373

  Fly   382 TQPFNGHSFMKFEMDINVLQIRGGSSVNSKSIGKW--ISGLN-SELIVKDEEQMKNLTADTVYRI 443
            .|.|..    .|.:||..|..:|     .:..|.|  .||:| :....:.::::..:..:....:
Mosquito   374 HQGFRS----DFVLDIVELGPQG-----LRKSGTWNSTSGVNFTRTYGEQQKEIVEILQNKTLIV 429

  Fly   444 FTVVQAPFIMRDETAPK-----GYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMD-ENGQWNG 502
            .|::.||:.||.::|.|     .::||.||||:||:.|:.|:|||:...||::|:.: |.|:|:|
Mosquito   430 TTILSAPYCMRKDSAEKLTGNSQFEGYAIDLIHEISKILGFNYTIRLAPDGRYGSHNKETGEWDG 494

  Fly   503 IVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRP-SSPSSLFKFLTVLETNVW 566
            ::|:|::::||:.:..:::..:||.|:|||:|:.:| ||:::.::| ..|.:||.||:.|..:||
Mosquito   495 MIKELLEQRADLAIADLTITFDREQVVDFTMPFMNL-GISVLYRKPVKQPPNLFSFLSPLSLDVW 558

  Fly   567 LCILAAYFFTSFLMWIFDRWSPYSYQN-NREKYKDDEEKREFNLKECLWFCMTSLTPQGGGEAPK 630
            :.:..||...|.|::|..|::||.:.. |......::.:.:|.|..|:||.:.||..||....||
Mosquito   559 IYMATAYLGVSVLLFILARFTPYEWPTPNPCDPHPEKLQTQFTLMNCMWFAIGSLMQQGCDFLPK 623

  Fly   631 NLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYF 695
            .:|.|:||..||.|..|:|:||||||||||||.|:|:|:||.:|||||.||.|..|.|.|...:|
Mosquito   624 AVSTRMVAGMWWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTKIKYGALRGGSTAAFF 688

  Fly   696 ERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAK---LPATLDEAV 757
             |.||.                                 ..|.:||..|:.|:   ..|:..|.|
Mosquito   689 -RDSNF---------------------------------STYQRMWSFMESARPSVFTASNIEGV 719

  Fly   758 ARVRNSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLL 822
            .||.....:  :|||.::|.|.|:...||:|..||.....|.|.||:...|..:...:.|:|.|.
Mosquito   720 ERVVKGKGS--YAFLMESTSIEYVIERNCELTQVGGMLDSKGYGIAMPPNSPFRTAISGAVLKLQ 782

  Fly   823 NKRQLEKLKEKWWKNDEALAKC----DKPEDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWW 883
            .:.:|..||.:|||.......|    .|....::.:.:.|:||||:|:..|:|:||:..|.|:.|
Mosquito   783 EEGKLHILKTRWWKEKRGGGSCRDDTSKSSSTANELGLANVGGVFVVLMGGMGVACVIAVCEFVW 847

  Fly   884 YRYRK---NPRIIDVAEANAE------RSNAAD--HPGKLVDGVILGHSGEKFEKSKAA------ 931
             :.||   ..|.:.:....|.      :.|.|.  |.|.  .|.:...|.....|..|:
Mosquito   848 -KSRKVAVEEREVSLCSEMASELRFALKRNRAQPKHAGS--GGTLRTASSRASPKDSASEPSSEH 909

  Fly   932 -----LRPRFNQYPATFKPR 946
                 |.|.:.||  .|.|:
Mosquito   910 GRFHPLGPPYAQY--EFDPK 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	76/426 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	144/408 (35%)
KaiR1D	XP_061498559.1	None