DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and Grik

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001262788.1	Gene:	Grik / 42476	FlyBaseID:	FBgn0038840	Length:	907	Species:	Drosophila melanogaster

Alignment Length:	1000	Identity:	246/1000 - (24%)
Similarity:	412/1000 - (41%)	Gaps:	225/1000 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIR------YGLSVQLD 73
            |||  :|:|..|.......:..||..:.|..:....|...:.::  |.|..      :|:||.::
  Fly    15 LGF--ILTSLLLAFPGCRGERTNVGLVYENTDPDLEKIFHLAIS--KANEENEDLQLHGVSVSIE 75

  Fly    74 ---SIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKSFTQALGLPTISASY 135
               |.|.:|...|:|.:.:...:..:               |.:|:....|...|..||.:..
  Fly    76 PGNSFETSKKLCKMLRQNLVAVFGPT---------------SNLAARHAMSICDAKELPFLDT-- 123

  Fly   136 GQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDHKYKSLLQ 200
                   :|   |...|...:.:.|....:..|:|.:|:.:...:..|:|:....:. ..:.|||
  Fly   124 -------RW---DFGAQLPTINLHPHPATLGVALRDMVVALGWESFTIIYESGEYLP-TVRELLQ 177

  Fly   201 NIQTRHVITAIAK---DGKREREEQIEKLRNLDINNFFILGTL----------QSIRMVLESVKP 252
            ...|......:.:   |........:.::||.|..:|.::|::          |.:.:|....:
  Fly   178 MYGTAGPTVTVRRYELDLNGNYRNVLRRIRNADDFSFVVVGSMATLPEFFKQAQQVGLVTSDYR- 241

  Fly   253 AYFERNFAWHAIT----QNEG------------------------EISSQRDNATIMFMKPMAYT 289
             |...|..||.:.    |:.|                        |......|.:......||..
  Fly   242 -YIIGNLDWHTMDLEPYQHAGTNITGLRLVSPDSEQVQEVAKALYESEEPFQNVSCPLTNSMALV 305

  Fly   290 QYRDRLGLLRTTY-NLNEEPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNTP 353
            .  |.:.||..|| ::|..|...|.                ....||.|....:|.
  Fly   306 Y--DGVQLLAETYKHVNFRPVALSC----------------NDDSAWDKGYTLVNY--------- 343

  Fly   354 QRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRGGSSVNSKSIGKWIS 418
            .::|.|..    :|.|..:....|.|.            |::::..|.:.|     .:.||:| |
  Fly   344 MKSLTLNG----LTGPIRFDYEGLRTD------------FKLEVIELAVSG-----MQKIGQW-S 386

  Fly   419 GLNSELIVKD-------------EEQMKNLTADTVYRIFTVVQAPFIMRDETAPK-----GYKGY 465
            |       :|             |..|::| .:..:.:.|.:..|:.|..||:.|     .::|:
  Fly   387 G-------EDGFQENRPAPAHSLEPDMRSL-VNKSFVVITAISEPYGMLKETSEKLEGNDQFEGF 443

  Fly   466 CIDLINEIAAIVHFDYTIQEVEDGKFGNMD-ENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVI 529
            .|:||:|::..:.|.||.:..||.|:|.:| :.|:|||::::::|.:||:|:..:::.:|||..:
  Fly   444 GIELIDELSKKLGFSYTWRLQEDNKYGGIDPKTGEWNGMLREIIDSRADMGITDLTMTSERESGV 508

  Fly   530 DFTVPYYDLVGITIMMQRP-SSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQN 593
            |||:|:..| ||.|:.::| ..|..||.|::.....|||.:..||...|..|::..|.||..:.|
  Fly   509 DFTIPFMSL-GIGILFRKPMKEPPKLFSFMSPFSGEVWLWLGLAYMGVSISMFVLGRLSPAEWDN 572

  Fly   594 NREKYKDDEE-KREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLA 657
            .....::..| :.:|:...||||.:.:|..||...|||..|.|.|||:||.|..|:::|||||||
  Fly   573 PYPCIEEPTELENQFSFANCLWFSIGALLQQGSELAPKAYSTRAVAASWWFFTLILVSSYTANLA 637

  Fly   658 AFLTVSRLDTPVESLDDLAK-QYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAV 721
            |||||..|.||:...|||:| :..:.|....|.:...:|:. ||
  Fly   638 AFLTVESLVTPINDADDLSKNKGGVNYGAKIGGATFNFFKE-SN--------------------- 680

  Fly   722 ERSKLAVWDYPVSDKYTKMWQAMQE--AKLPATLDEAVARVRNSTAATGFAFLGDATDIRYLQLT 784
                     ||.   |.:|::.|::  ..:..|..|.|.||.||    .:|||.::|.|.|:...
  Fly   681 ---------YPT---YQRMYEFMRDNPQYMTNTNQEGVDRVENS----NYAFLMESTTIEYITER 729

  Fly   785 NCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPED 849
            .|.|..||.....|.|.||:::....:|..:.|:|.:..:..|.|:|.|||:.......|...::
  Fly   730 RCTLTQVGALLDEKGYGIAMRKNWPYRDTLSQAVLEMQEQGLLTKMKTKWWQEKRGGGACSDADE 794

  Fly   850 QSDGIS--IQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRIIDVAEANAERSNAADHPGKL 912
            .|..::  |.|:||||:|:.||........:.|          .::.|.|.:.|  |......:|
  Fly   795 DSGAVALEISNLGGVFLVMGVGSFFGIFVSLLE----------MVLGVKERSDE--NQVSFKTEL 847

  Fly   913 VDGV--ILGHSGEKFEKSKAALRPR 935
            :|.:  ||..||    .:||...|:
  Fly   848 LDEIRFILQCSG----NTKAVKYPK 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	75/436 (17%)
		PBP2_iGluR_putative	438..836	CDD:270435	133/408 (33%)
		Lig_chan	565..870	CDD:278489	101/310 (33%)
Grik	NP_001262788.1	PBP1_iGluR_Kainate	37..391	CDD:107377	76/441 (17%)
		ANF_receptor	53..374	CDD:279440	66/395 (17%)
		Periplasmic_Binding_Protein_Type_2	411..781	CDD:304360	133/408 (33%)
		Lig_chan	543..816	CDD:278489	100/310 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462879
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.940