Protein Alignment Ir25a and Nmdar1

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_730940.1
• Gene: Nmdar1 / 40665
• FlyBaseID: FBgn0010399
• Length: 997
• Species: Drosophila melanogaster
• Alignment Length: 991
• Identity: 236/991 - (23%)
• Similarity: 404/991 - (40%)
• Gaps: 242/991 - (24%)

  Fly     5 NPKTSKILWLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIRYGLS 69
            ||.|..|   .|.||  :|.|.|..:.|.:::|      .|.:...:.|    ||..|.||
  Fly    35 NPSTYNI---GGVLS--NSDSEEHFSTTIKHLN------FDQQYVPRKV----TYYDKTIR---- 80

  Fly    70 VQLDSIEANKSDAKVLLEAICNK------YATSIEKKQTPHLILDTTKSGIASETVKSFTQAL-G 127
                   .:|:..|.:.. :|:|      ||..:..:||         ||..|....|:|... .
  Fly    81 -------MDKNPIKTVFN-VCDKLIENRVYAVVVSHEQT---------SGDLSPAAVSYTSGFYS 128

  Fly   128 LPTISASYGQQGDLRQWRDL---DEAKQKYLLQVMPP----ADIIPEAI------RSIVIHMNIT 179
            :|.|..|.         ||.   |:......|:.:||    ||:..|.:      :.|:||.:.|
  Fly   129 IPVIGISS---------RDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDT 184

  Fly   180 NA-AIL----------YDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINN 233
            :. |||          |||              :..|..:..|.     |.|.::|..    ..:
  Fly   185 DGRAILGRFQTTSQTYYDD--------------VDVRATVELIV-----EFEPKLESF----TEH 226

  Fly   234 FFILGTLQS-IRMVLESVKPAYFERNFAWHAITQNEGEIS-SQRDNATIMFMKPMAYTQYRDRLG 296
            ...:.|.|| :.::..|.:.|        ..|.::.||.: :...:..|:..:.:......|.:.
  Fly   227 LIDMKTAQSRVYLMYASTEDA--------QVIFRDAGEYNMTGEGHVWIVTEQALFSNNTPDGVL 283

  Fly   297 LLRTTYNLNEEPQLSSAFYFDLALRSFLTIKEMLQS---GAWPKDMEYLNCDD----FQGGNTPQ 354
            .|:..:..:::..:..:.|   .|.|  .||||:.:   ...|||     |.|    ::.|....
  Fly   284 GLQLEHAHSDKGHIRDSVY---VLAS--AIKEMISNETIAEAPKD-----CGDSAVNWESGKRLF 338

  Fly   355 RNLDLRDYFTKITEPTS-----------YGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRGGSSV 408
            :.|..|:    ||..|.           |..:|::....|. ..|...||..|....::|  ..:
  Fly   339 QYLKSRN----ITGETGQVAFDDNGDRIYAGYDVINIREQQ-KKHVVGKFSYDSMRAKMR--MRI 396

  Fly   409 NSKSIGKWISGLNSELIVKDEEQMK--NLTADTVYRIFTVVQAPFIM------------------ 453
            |           :||:|...:::.|  .:...|..|:.|:.:.||:.
  Fly   397 N-----------DSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDERPC 450

  Fly   454 -----RDETAPK-GYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGN---------MDENGQWNGI 503
                 .|.||.: ..:||||||:.|::..::|.|.:....||:||:         |....:|.|:
  Fly   451 PLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGL 515

  Fly   504 VKKLMDKQADIGLGSMSVMAEREIVIDFTVPY-YDLVGITIMMQRPSSPSSLFKFLTVLETNVWL 567
            :.:|::::||:.:..:::..||...|:|:.|: |.  ||||:.::||..|:|..||......:|:
  Fly   516 IGELVNERADMIVAPLTINPERAEYIEFSKPFKYQ--GITILEKKPSRSSTLVSFLQPFSNTLWI 578

  Fly   568 CILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLWFCMTSLTPQGGGE-APKN 631
            .::.:....:.::::.||:||:.  ..:..:.|..|::..||...:||....|...|.|| .|::
  Fly   579 LVMVSVHVVALVLYLLDRFSPFG--RFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRS 641

  Fly   632 LSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLA---KQYKILYAPLNGSSAMT 693
            .|.|::...|..|..||:|||||||||||.:.|..|.:..::|..   ....:..|.:.|||...
  Fly   642 FSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDM 706

  Fly   694 YFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAVA 758
            ||.|...:..|:    :.:..|:..||.                    ||:|:.|....:
  Fly   707 YFRRQVELSNMY----RTMEANNYATAE--------------------QAIQDVKKGKLM----- 742

  Fly   759 RVRNSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLN 823
                       ||:.|::.:.|....:|:|...||.|.|..|.|.:|:||...|....|||....
  Fly   743 -----------AFIWDSSRLEYEASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHE 796

  Fly   824 KRQLEKLKEKWWKNDEALAKCDKPEDQSDGISIQNIGGVFIVIFVGI--GMACITLVFEYWWYRY 886
            ...:|||.::|..:......|:..|...:.:.::|:.||||::.|||  |:..|.:...|..::.
  Fly   797 SGFMEKLDKQWIFHGHVQQNCELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQV 861

  Fly   887 RKNPRIIDVAEANAER 902
            :|..| :|:|...|::
  Fly   862 KKQKR-LDIARHAADK 876

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	86/431 (20%)
		PBP2_iGluR_putative	438..836	CDD:270435	117/435 (27%)
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	37..405	CDD:380602	98/471 (21%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	117/444 (26%)
		CaM_bdg_C0	854..882	CDD:402271	6/24 (25%)