DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and gria1b

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_991293.1	Gene:	gria1b / 403044	ZFINID:	ZDB-GENE-020125-2	Length:	917	Species:	Danio rerio

Alignment Length:	1007	Identity:	259/1007 - (25%)
Similarity:	440/1007 - (43%)	Gaps:	222/1007 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SKILWLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIRYGLS---- 69
            |.:|.|.|.|.|.|..|.      ..|||:..:...|:.    ..:|        .|:.||
Zfish     4 SFVLLLTGLLGLCSCSSF------PSNINIGGLFPTDSH----EYDV--------FRFALSQHND 50

  Fly    70 -----VQLDSIEANKSDAKVLLEAICNKYATSI------EKKQTPHLILDTTKSGIASETVKSFT 123
                 .|:|.::...|.|  :..|.|::::..:      ..::|.::::             ||.
Zfish    51 VPKLVPQVDMVDTGSSFA--MTYAFCSQFSKGVYAIIGLYDRKTMNMLM-------------SFC 100

  Fly   124 QALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDS 188
            .||.:..::.|:          .:|...| :::|:.|.   :.:|:.::|.|........:|...
Zfish   101 GALHVCFVTPSF----------PIDTNNQ-FVIQLRPE---LQDALIALVEHYKWNKFVYMYSSD 151

  Fly   189 FVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFF--ILG-TLQSIRMVLESV 250
            ..:....|.|....:....:|:|..|...| ...::.:::||....|  ||. .|:.:..:|..:
Zfish   152 SGLTVLQKILDTAAEKTWQVTSINFDTLTE-AAFLKAIQDLDNKKEFKIILDCELERLNSILNLI 215

  Fly   251 KPAYFERNFA-WHAITQNEGEI-----SSQRDNATIMFMKPMAYTQYRDRLGLLRTTYNLNEEPQ 309
              |..::|.. :|.|..|.|.:     ..::..|.:...:.|.||                 .|.
Zfish   216 --AAQKKNLKNYHYILANLGFLDLNLTEFRKGGANVTGFQLMNYT-----------------NPT 261

  Fly   310 LSSAF--YFDLALRSFLTIKEMLQ-SGAWPKDMEYLNCDDFQGGNTPQRNLDLR------DYFTK 365
            :|...  :.:...:...:.|..|: :||...|...:....||  |..::.:|:.      :....
Zfish   262 VSRTIQDWLEFDSKDLKSPKRRLKYTGALTYDGVTVMATAFQ--NLRKQRIDISRRGNAGECLAN 324

  Fly   366 ITEPTSYG----------TFDLVTQSTQPFN--GHSFMKFEMDINVLQIRGGSSVNSKSIGKW-- 416
            ...|...|          .|:.:|...| ||  ||   :....::|::.  |.| ..|.:|.|
Zfish   325 PPAPWGQGIDIQRALQQVQFEGLTGHVQ-FNDKGH---RTNFTVSVMEF--GPS-GPKKVGYWNQ 382

  Fly   417 ----ISGLNSELIVKDEEQMKNLTADTVYRIFTVVQAPFIMRDETAPK-----GYKGYCIDLINE 472
                :|......::.:...::|.|    |.:.|:::||::|..:...:     .|:|||::|..|
Zfish   383 REKYVSTATYSNMLNETFGLQNRT----YVVTTILEAPYVMLKKNHEQLVGNDKYEGYCVELAAE 443

  Fly   473 IAAIVHFDYTIQEVEDGKFGNMD-ENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYY 536
            ||..|.:.|.::.|.|||:|..| |...|||:|.:|:..:||:.:..:::...||.||||:.|:.
Zfish   444 IAKHVGYSYRLELVGDGKYGARDAETMMWNGMVGELVYGKADVAVAPLTITLVREEVIDFSKPFM 508

  Fly   537 DLVGITIMMQRPS-SPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSY--------- 591
            .| ||:||:::|: |...:|.||..|...:|:||:.||...|.::::..|:|||.:
Zfish   509 SL-GISIMIKKPTKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHADDEEETA 572

  Fly   592 --------------------QNNRE--KYKDDEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSG 634
                                ||.||  :.|..|...||.:...|||.:.:...||...:|::|||
Zfish   573 DQQNQNQPPSPEPNQSPNQSQNQREEKQEKQPEHTNEFGIFNSLWFSLGAFMQQGCDISPRSLSG 637

  Fly   635 RLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMS 699
            |:|...||.|..|||:||||||||||||.|:.:|:||.:|||||.:|.|..|:|.|...:|
Zfish   638 RIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDGGSTKEFF---- 698

  Fly   700 NIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAK---LPATLDEAVARVR 761
                                  .|||:||::        |||..|:.|:   ...|.||.|.|||
Zfish   699 ----------------------RRSKIAVFE--------KMWSYMKSAEPTVFVKTTDEGVVRVR 733

  Fly   762 NSTAATGFAFLGDATDIRYL-QLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKR 825
            .|...  :|:|.::|...|: |...||...||.....|.|.:|..:||.|::..|.|:|.|..:.
Zfish   734 KSKGK--YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNPVNLAVLKLNEQG 796

  Fly   826 QLEKLKEKWWKNDEALAKCDK----PEDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWW--- 883
            .|:|||.|||.:.   .:|..    .:|::..:|:.|:.|||.::..|:|:|.:..:.|:.:
Zfish   797 LLDKLKNKWWYDK---GECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALVEFCYKSR 858

  Fly   884 YRYRKNPRIIDVA--EANAERSNAADHPGKLV 913
            ...|:..:|||.|  .:...|..:....|:::
Zfish   859 IESRRMKQIIDAAMLSSTLTRMGSGGENGRVM 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	75/436 (17%)
		PBP2_iGluR_putative	438..836	CDD:270435	152/439 (35%)
		Lig_chan	565..870	CDD:278489	113/343 (33%)
gria1b	NP_991293.1	PBP1_iGluR_AMPA_GluR1	26..387	CDD:107385	75/430 (17%)
		ANF_receptor	41..368	CDD:279440	67/381 (18%)
		PBP2_iGluR_AMPA_GluR1	404..812	CDD:270447	155/451 (34%)
		Lig_chan	536..842	CDD:278489	113/344 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591506
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840