Protein Alignment Ir25a and Ir64a

DIOPT Version :10

• Sequence 1: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_647962.1
• Gene: Ir64a / 38616
• FlyBaseID: FBgn0035604
• Length: 859
• Species: Drosophila melanogaster
• Alignment Length: 703
• Identity: 129/703 - (18%)
• Similarity: 230/703 - (32%)
• Gaps: 229/703 - (32%)

  Fly   222 QIEKLRNLDINNFFILGTLQSIRMVLESVKPAYFER-------NFAWHAITQNEGEISSQRDNAT 279
            ::|.||.:.:.: ...|.:....:.|.|.|..|.|:       :||||..||. .|.|.:||:..
  Fly   148 RMEALRQIAVVD-LACGAVSRRFLELASAKMLYSEKFHWLLIEDFAWHGRTQT-AEGSGKRDDGE 210

  Fly   280 IMFMKPMAYTQYRDRLGLLRTTYNLNEEPQLSSAFYF----DLALRSFLTIKEMLQSGA------ 334
            :...:|....        ::.|    ::..|.|...|    :|.:.:.||:.:.:...|
  Fly   211 MEEEEPPGQQ--------IQAT----DDEDLPSIESFLGGMNLYMNTELTLAKRMSEAAHYTLFD 263

  Fly   335 -WPKDMEY---LNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEM 395
             |...:.|   :|..:. |..||...:.|..:|.              |.||        ::..|
  Fly   264 VWNPGLNYGGHVNLTEI-GSFTPTEGIQLHTWFR--------------TTST--------VRRRM 305

  Fly   396 DINVLQIRGGSSVNSKSIGKWISGLNSELIVKDEEQMKNLTADTVYRIFTVVQAPFIMRDETAPK 460
            |:...::|                  ..::|.:    ||:|...:|.:...:
  Fly   306 DMQHARVR------------------CMVVVTN----KNMTGTLMYYLTHTM------------- 335

  Fly   461 GYKGYCIDLINE------IAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGSM 519
              .|: ||.:|.      :|....|::|........:|.: :||:::|::..|:..:.|||...:
  Fly   336 --SGH-IDTMNRFNFNLLMAVRDMFNWTFVLSRTTSWGYV-KNGRFDGMIGALIRNETDIGGAPI 396

  Fly   520 SVMAEREIVIDFTVPYYDLVGITIMMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFD 584
            ....||...||.....:......|.....|:......||.....:||:.|:.....|.|::|...
  Fly   397 FYWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIVFLQPFTNDVWILIVGCGVLTVFILWFLT 461

  Fly   585 --RW----------------SP----YSYQNNRE-----------------KYKDDEEKREFN-- 608
              .|                :|    |..|..:|                 |.|.:|::.|:.
  Fly   462 TIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDS 526

  Fly   609 ------------------------------------LKECLWFCMTSLTPQGGGEAPKNLSGRLV 637
                                                ..|.:.|.:..:..||.|.:...:|||.:
  Fly   527 TPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCI 591

  Fly   638 AATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIE 702
            ..|..||.|.|...|:|::...|.:.:..| :::|.||..           ||.....|.:....
  Fly   592 VITSLLFSFCIYQFYSASIVGTLLMEKPKT-IKTLSDLVH-----------SSLKVGMEDILYNR 644

  Fly   703 QMFYEIWKDLSLN---DSLTAVERSKLAVWD-------YPVSDKYTKMWQAMQEAKLPATLDEAV 757
            ..|......:|:.   ..:|:|..:|....|       .|||....|.::.:..:      .|..
  Fly   645 DYFLHTKDPVSMELYAKKITSVPTTKENEADEDEPVDPNPVSTDPAKSYRDIVHS------HETG 703

  Fly   758 ARVRNSTAAT------------GFAFLGDATDIRYLQLTNCDLQVVGEEFSRK 798
            |..:::.|:.            ||||..|..         ...:::.|.||.:
  Fly   704 AHAKDNAASNWLDPETGLLRHLGFAFHVDVA---------AAYKIIAETFSEQ 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	42/216 (19%)
		PBP2_iGluR_putative	438..836	CDD:270435	83/466 (18%)
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:473866	25/114 (22%)
		Lig_chan	563..828	CDD:459656	44/212 (21%)