DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and gria3b

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_938174.1	Gene:	gria3b / 368416	ZFINID:	ZDB-GENE-030616-53	Length:	883	Species:	Danio rerio

Alignment Length:	967	Identity:	264/967 - (27%)
Similarity:	431/967 - (44%)	Gaps:	188/967 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ILWLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIR---YGLSVQL 72
            :|||.|  :.|:.|..:|      ||..||:.....|.:|....|.|....:|:.   :.|:..:
Zfish     9 LLWLFG--TSLAGFPNQI------NIGGLFMRSTVQEHSAFRFAVQLYNTNQNMTEKPFHLNYNV 65

  Fly    73 DSIEANKSDAKVLLEAICNKYATSI-------EKKQTPHLILDTTKSGIASETVKSFTQALGLPT 130
            |::|::.|.:  :..|.|::::..:       :||              :..|:.||..||....
Zfish    66 DNLESSNSFS--VTHAFCSQFSRGVYAIFGFYDKK--------------SMNTLTSFCGALHTSF 114

  Fly   131 ISASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDHKY 195
            ::.||....|:           ::::|:.||   :..|:.|::.|........|||    .|..:
Zfish   115 VTPSYPIDSDV-----------QFVIQMRPP---LKGAVLSLLSHYKWDKFVYLYD----TDRGF 161

  Fly   196 KSLLQNIQTRHV-----ITAIAKDGKREREE---QIEKLRNLDINNFFILGTLQSIRMVLESVKP 252
             |:||.|....|     :||.:.....:.:|   .||::.......:.|...:..|.::||.| .
Zfish   162 -SILQAIMEAAVANNWQVTARSVGSITDPQEFRRIIEEMDRRQEKRYLIDCEVDRINVILEQV-V 224

  Fly   253 AYFERNFAWHAITQNEGEISSQRDNATI--------MFMKP-----MAYTQYRDRLGLLRTTYNL 304
            ...:.:..:|.|..|.|..:...|...:        ..:.|     ..:.|..|||.........
Zfish   225 TLGKNSRGYHYIIANLGFTNISLDKVFLGGANISGFQIINPENLVVQQFLQRWDRLDEREFPEAK 289

  Fly   305 NEEPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNTPQRNLDLR------DYF 363
            |...:.:||..:|    :.|.|.|..:         ||.          ::.:|:.      |..
Zfish   290 NTPLKYTSALSYD----AILVIAEAFR---------YLR----------RQRVDVSRRGSAGDCL 331

  Fly   364 TKITEPTSYGTFD----LVTQSTQPFNGH----SF-MKFEMDINVLQIRGGSSVNSKSIGKW--- 416
            .....|.|.| .|    |.....|...|:    || .:....|:|.:::.|   ..:.||.|
Zfish   332 ANPAVPWSQG-IDIERALKMVQVQGMTGNIQFDSFGRRTNYTIDVYEMKTG---GPRKIGYWNEF 392

  Fly   417 --ISGLNSELIVKDEEQMKNLTADTVYRIFTVVQAPFIMRDET-----APKGYKGYCIDLINEIA 474
              ...:..:....|...::|.|    ..:.|:::||::|..:.     ..:.|:|||:||.:|||
Zfish   393 ERFVNIMDQQFTNDSSSVENRT----IVVTTIMEAPYVMYKKNHMHLEGNEKYEGYCVDLASEIA 453

  Fly   475 AIVHFDYTIQEVEDGKFGNMD-ENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDL 538
            ..|...|.:..|.|||:|..| |...|||:|.:|:..:|||.:..:::...||.||||:.|:..|
Zfish   454 KHVGIKYRLSIVMDGKYGARDPETKSWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSL 518

  Fly   539 VGITIMMQRP-SSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQ-NNREKYKD- 600
             ||:||:::| .|...:|.||..|...:|:||:.||...|.::::..|:|||.:| :..::.||
Zfish   519 -GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWQLDETDEVKDP 582

  Fly   601 ---DEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTV 662
               .:...:|.:...|||.:.:...||...:|::||||:|...||.|..|||:||||||||||||
Zfish   583 QTPPDPPNDFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTV 647

  Fly   663 SRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLA 727
            .|:.:|:||.:|||||.:|.|..|:..|...:|                          .|||:|
Zfish   648 ERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFF--------------------------RRSKIA 686

  Fly   728 VWDYPVSDKYTKMWQAMQEAK---LPATLDEAVARVRNSTAATGFAFLGDATDIRYL-QLTNCDL 788
            |        |.|||..|:.|:   ...|..:.|||||.|...  ||||.::|...|: |...||.
Zfish   687 V--------YEKMWSYMKSAEPSVFAKTTPDGVARVRKSKGK--FAFLLESTMNEYIEQRKPCDT 741

  Fly   789 QVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDK----PED 849
            ..||.....|.|.:|..:||.|::..|.|:|.|..:..|:|||.|||.:.   .:|..    .:|
Zfish   742 MKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDK---GECGSGGGDSKD 803

  Fly   850 QSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRIIDVAEANAERSNAA 906
            ::..:|:.|:.|||.::..|:|:|.:..:.|: .|:.|...:.:.: |.||:....|
Zfish   804 KTSALSLSNVAGVFYILVGGLGLAMMVALIEF-CYKSRAEAKRLKL-EKNAQNYKPA 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	83/436 (19%)
		PBP2_iGluR_putative	438..836	CDD:270435	150/413 (36%)
		Lig_chan	565..870	CDD:278489	110/317 (35%)
gria3b	NP_938174.1	Periplasmic_Binding_Protein_Type_1	25..396	CDD:299141	86/433 (20%)
		ANF_receptor	36..379	CDD:279440	78/402 (19%)
		PBP2_iGluR_AMPA	412..794	CDD:270433	153/425 (36%)
		Lig_chan	544..824	CDD:278489	110/318 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591887
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.840