DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir25a and Ir40a

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster

Alignment Length:	491	Identity:	97/491 - (19%)
Similarity:	169/491 - (34%)	Gaps:	146/491 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   487 EDGKFGNMDENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSP 551
            ||||    |.|..:.|.:..|...|||..||.:.:..||...|:|:  ::.|.........  :|
  Fly   293 EDGK----DSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLADSGAFATH--AP 349

  Fly   552 SSLFKFLTVL---ETNVWLCILAAYFFTS-------FLMWIF-DRWSPYSYQNNRE-----KYKD 600
            ..|.:.|.::   :.::|..::....|:.       .|.:|: .||:....::..|     .|..
  Fly   350 RRLNEALAIMRPFKQDIWPHLILTIIFSGPIFYGIIALPYIWRRRWANSDVEHLGELYIHMTYLK 414

  Fly   601 DEEKREFNLK----------------ECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIII 649
            :...|...||                :|:||.:.....|...|.......:.:...:|:....::
  Fly   415 EITPRLLKLKPRTVLSAHQMPHQLFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVYWIAATYVL 479

  Fly   650 AS-YTANLAAFLTVSRLDTPVESLDDLAKQ-----YKILYAPLNGSSAMTYFERMSNIEQMF--- 705
            |. |:|.|.:.......:.|:.:|..|...     |: ||.....||    .|.:.|..::|
  Fly   480 ADVYSAQLTSQFARPAREPPINTLQRLQAAMIHDGYR-LYVEKESSS----LEMLENGTELFRQL 539

  Fly   706 YEIWKDLSLNDS----LTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPAT--LDEAVARVRNST 764
            |.:.:...:||.    :.:||..                      .||.|.  .|:||
  Fly   540 YALMRQQVINDPQGFFIDSVEAG----------------------IKLIAEGGEDKAV------- 575

  Fly   765 AATGFAFLGDATDIRYLQLTNCDLQVVGE---EFSRKPY----AIAVQQGSHLKDQFNNAILTLL 822
                   ||....:.:      ::|..|.   :.|:|.|    |:|||.|.......||.::.|.
  Fly   576 -------LGGRETLFF------NVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLF 627

  Fly   823 NKRQLEKLKEKWW-------------------KNDEALAKCDKPEDQ-SDGISIQNIGGVFIVIF 867
            ....|:|:....:                   ||.||.::.:..:.. ...::::.:.|.||.:.
  Fly   628 ESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALG 692

  Fly   868 VGIGMACITLVFE----------YW-------WYRY 886
            ||...|.:.|:.|          .|       |.||
  Fly   693 VGSLAAGVILLLEIVFIKLDQARLWMLCSRLQWIRY 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378
		PBP2_iGluR_putative	438..836	CDD:270435	81/421 (19%)
		Lig_chan	565..870	CDD:278489	68/375 (18%)
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	17/50 (34%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	20/97 (21%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	39/187 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463017
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840