DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and clumsy

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster

Alignment Length:	934	Identity:	235/934 - (25%)
Similarity:	390/934 - (41%)	Gaps:	162/934 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LWLLGFLSLLSSFSLEIAAQTTQN---INVLFINEVD-NEPAAKAVEVVLTYLKKNIRYGLSVQL 72
            |:|..||.:    :|.:.|...::   :..:|.::.| :|.|.:........|::|:.....|
  Fly     4 LFLTHFLLI----ALPVLADIDRSQFMVGSIFTSDKDESEIAFRTAVDRANILERNVELVPIV-- 62

  Fly    73 DSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKSFTQALGLPTISASYGQ 137
              :.||..|:.::.:.:||..:..:       :.:....:|.:|:.:.|....|.:|.|...:..
  Fly    63 --VYANTDDSFIMEKMVCNLISQGV-------IAIFGPSTGSSSDIIASICDTLDIPHIVYDWIP 118

  Fly   138 QGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDHKYKSLLQNI 202
            ...:.     |.......|.|.|...::.:.:..||......:..::|:    .|.:.:.|...:
  Fly   119 NESIP-----DREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYE----TDKELQQLQDIL 174

  Fly   203 QTRHVI---TAIAKDGKREREEQIEKLRNLDINNFFI--------------------LGTLQSIR 244
            |....|   |.:.:.|..:......|...|..:|..|                    ||..||:.
  Fly   175 QVGEPISNPTTVKQLGPGDDHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVF 239

  Fly   245 MVLESVKPAYFERNFAWHAITQNEGEISSQRDN-ATIMFMKPMAYTQYRDRLGLLRTTYNLNEEP 308
            :.|...           |:|  :.||:|....| .|:..|.|..:.        ::...:..||.
  Fly   240 IPLLDT-----------HSI--DFGELSGVEANITTVRLMDPSDFH--------VKNVVHDWEER 283

  Fly   309 QLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNTPQRNLDLR------------D 361
            :.....||.:......:...:|....|...........|:....|  :|:.|            :
  Fly   284 EKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTELGIFEELTAP--DLECRRKKPWPFGKRIIE 346

  Fly   362 YFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRGGSSVNSKSIGKW--ISGLNSEL 424
            :....:|.||.|..|......:.|....||:...|            ....:..|  ::||  ::
  Fly   347 FIKARSEETSTGRIDFNENGQRSFFTLRFMELNSD------------GFLDLATWDPVNGL--DV 397

  Fly   425 IVKDEEQMKNLTADTVYRIFTV---VQAPFIMRDE-------TAPKGYKGYCIDLINEIAAIVHF 479
            :..|||..|.:......:.|.|   :.|||:...|       |....|:||.||||||||.:::|
  Fly   398 LNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNF 462

  Fly   480 DYTIQEVEDGKFGNMDENGQ-WNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITI 543
            .:..:...|||:|.:::..| |:|||::|:|..||:|:..:::.:.|...:|||.|:..| ||:|
  Fly   463 KFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTL-GISI 526

  Fly   544 MMQR-PSSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEEKREF 607
            :..: |:.|:.||.||:....:||:.:.:||.|.|.|::...|.:|..::|.....:.:|.:..:
  Fly   527 LFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCKEPEEVENIW 591

  Fly   608 NLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESL 672
            ::....|..:.||..||....||..|.|||...||.|..:::.|||||||||||.||....:.|.
  Fly   592 SIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSA 656

  Fly   673 DDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKY 737
            :|||.|.||.|..:.|.|.|.:| |.||.                                 ..|
  Fly   657 EDLAAQSKIKYGAMAGGSTMGFF-RDSNF---------------------------------STY 687

  Fly   738 TKMWQAMQEAK---LPATLDEAVARVRNSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEFSRKP 799
            .|||.||:.|.   ...|.||.|.||:.....  :|||.::|.:.|.....|||..:|.....|.
  Fly   688 QKMWTAMESASPSVFTKTNDEGVERVQKGKNL--YAFLMESTTLEYNVERKCDLVQIGGWLDYKS 750

  Fly   800 YAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQSDG-----ISIQNI 859
            |.||:...|..:.|.:.|:|.|....||.:||.||||.......|:|.::  ||     :.::|:
  Fly   751 YGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDE--DGGDTPELGLENV 813

  Fly   860 GGVFIVIFVGIGMACITLVFEYWW 883
            ||||:|:.:|:..|.:....|:.|
  Fly   814 GGVFLVLGLGLLSAMVLGCTEFLW 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	71/424 (17%)
		PBP2_iGluR_putative	438..836	CDD:270435	138/412 (33%)
		Lig_chan	565..870	CDD:278489	102/312 (33%)
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	71/426 (17%)
		ANF_receptor	39..379	CDD:279440	65/382 (17%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	138/409 (34%)
		Lig_chan	548..812	CDD:278489	96/301 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462696
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1556
Isobase	1	0.950	-	0	Normalized mean entropy	S6275
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.840