DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and gria4b

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_997917.2	Gene:	gria4b / 336069	ZFINID:	ZDB-GENE-030131-8013	Length:	904	Species:	Danio rerio

Alignment Length:	970	Identity:	256/970 - (26%)
Similarity:	419/970 - (43%)	Gaps:	223/970 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 AAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIR---YGLSVQLDSIEANKSDAKVLLEAIC 90
            |..::..|..|||...|.|..|..:.:.|.....|..   :.|...:|:||...|.|  :..|.|
Zfish    22 AFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFA--VTNAFC 84

  Fly    91 NKYATSI------EKKQTPHLILDTTKSGIASETVKSFTQALGLPTISASYGQQGDLRQWRDLDE 149
            ::|:..:      ..|::.|             |:.||..||.:..|:.|:..:|:
Zfish    85 SQYSRGVFAIFGLYDKRSVH-------------TLTSFCGALHISLITPSFPTEGE--------- 127

  Fly   150 AKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYD---------------------------D 187
              .:::||:.|.   |..|:.|::.|.:......|||                           :
Zfish   128 --SQFVLQLRPS---IRGALLSLLDHYDWNRFVFLYDTDRGYSILQAIMEKAGQNGWQVSAICVE 187

  Fly   188 SFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSIRMVLESVKP 252
            :| .|..|:.||:::..|...|.:.       :.:.|:|.|:          |:.|..|.:.||
Zfish   188 NF-NDASYRQLLEDLDRRQEKTFVI-------DLEAERLNNM----------LEQIVSVGKHVK- 233

  Fly   253 AYFERNFAWHAITQNEG--EISSQR-----DNAT----IMFMKPMAYTQYRDRLGLLRTTYNLNE 306
                   .:|.|..|.|  :|:.:|     .|.|    :.|..||.       :.|::....|::
Zfish   234 -------GYHYIMANLGFKDINLERFMHGGANVTGFQLVDFSNPMV-------IKLMQRWNKLDQ 284

  Fly   307 E--------PQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNTPQRNLDLR--- 360
            .        |:.:||..:|    ..:.:.|..:                   |..::.:|:.
Zfish   285 REYPGSDAPPKYTSALTYD----GVMVMAEAFR-------------------NLRRQKVDISRRG 326

  Fly   361 ---DYFTKITEPTSYGTFDL-----------VTQSTQPFNGHSFMKFEMDINVLQIRGGSSVNSK 411
               |.......|.:.| .|:           :|.:.|..:....:.:.||:..|:..|     .:
Zfish   327 IAGDCLANPAAPWNQG-IDMERTLKQVHLQGLTGNVQFDHYGRRVNYTMDVFELKSNG-----PR 385

  Fly   412 SIGKWISGLNSELIVKDEEQMKNLTADTVYR---IFTVVQAPFIMRDET-----APKGYKGYCID 468
            .||.| :..:..::.:|...:.|.|:....|   :.|:::.|::|..:.     ..:.|:|||:|
Zfish   386 RIGYW-NDADKLVLTQDHALLPNETSGMENRTVIVTTIMEGPYVMLKKNWEMYEGNEQYEGYCVD 449

  Fly   469 LINEIAAIVHFDYTIQEVEDGKFGNMD-ENGQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFT 532
            |.:|||..:.|.|.|..|.|||:|..| |...|||:|.:|:..:|:|.:..:::...||.||||:
Zfish   450 LASEIAKHIGFKYKISIVPDGKYGARDPETKIWNGMVGELVYGKAEIAVAPLTITLVREEVIDFS 514

  Fly   533 VPYYDLVGITIMMQRP-SSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSY----- 591
            .|:..| ||:||:::| .|...:|.||..|...:|:||:.||...|.::::..|:|||.:
Zfish   515 KPFMSL-GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEP 578

  Fly   592 QNNREKYKDDEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANL 656
            :...:....|:...||.:...|||.:.:...||...:|::||||:|...||.|..|||:||||||
Zfish   579 EEGTDGLPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANL 643

  Fly   657 AAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAV 721
            ||||||.|:.:|:||.:|||||..|.|..|:..|...:|
Zfish   644 AAFLTVERMVSPIESAEDLAKQTDIAYGTLDSGSTKEFF-------------------------- 682

  Fly   722 ERSKLAVWDYPVSDKYTKMWQAMQEAK---LPATLDEAVARVRNSTAATGFAFLGDATDIRYL-Q 782
            .|||:||        |.|||..|:.|:   ...|..|.|||||.|...  :|||.::|...|. |
Zfish   683 RRSKIAV--------YEKMWSYMKSAEPTVFTKTTAEGVARVRKSKGK--YAFLLESTMNEYTEQ 737

  Fly   783 LTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWW--KNDEALAKCD 845
            ...||...||.....|.|.:|..:||.|:...|.|:|.|..:..|:|||.|||  |.:.......
Zfish   738 RKPCDTMKVGGNLDSKGYGVATPKGSQLRSAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGG 802

  Fly   846 KPEDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRIIDVAEANAERSNA 905
            :.:..|..:|:.|:.|||.::..|:|:|.:..:.|: .|:.|...:.:.:....|.|:.|
Zfish   803 EKDKSSQALSLSNVAGVFYILVGGLGLAMLVALIEF-CYKSRNEAKRMKLTFTEAMRNKA 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	84/457 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	150/418 (36%)
		Lig_chan	565..870	CDD:278489	109/315 (35%)
gria4b	NP_997917.2	Periplasmic_Binding_Protein_Type_1	28..398	CDD:324556	86/461 (19%)
		PBP2_iGluR_AMPA_GluR4	414..793	CDD:270445	150/415 (36%)
		Lig_chan	546..827	CDD:306551	109/316 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591797
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840