DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir25a and Ir8a

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster

Alignment Length:	919	Identity:	271/919 - (29%)
Similarity:	440/919 - (47%)	Gaps:	140/919 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 EPAAKA-----VEVVLTYLKKNIRYGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLI 106
            ||..:|     :.:||..|.. :|..:.|...::...:|:..:.::..|...:|     .....:
  Fly    27 EPVQRAEFDTDIAMVLKELDA-LRLDVKVDDTTLTLTRSEDGLDMQRFCEILST-----VGASAV 85

  Fly   107 LDTTKSGIASETVKSFTQALGLPTISASYGQQGDLRQWRDL--DEAKQKYLLQVMPPADIIPEAI 169
            :|.|.|  ..|...:..::||:..:..    :..:|.:.|:  |..:||             .|.
  Fly    86 IDLTYS--HWEEGYNLVRSLGIGYVRL----ERIMRPFLDMFGDFMRQK-------------RAN 131

  Fly   170 RSIVIHMNITNAAILYDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQ--IEKLRNLDIN 232
            ...::.||..:|.              ..:|.:...:....:..|..:....|  :|::|:|...
  Fly   132 NVAMVFMNARDAV--------------EAMQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPA 182

  Fly   233 NFFILGTLQSIRM--VLESVKPA-YFERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDR 294
            ..:|....::..|  :.|.|:.| .|:|...||.:      ....||..          .:|| |
  Fly   183 PTYIALFARAAAMNGIFEKVQKADLFQRPLEWHFV------FLDTRDRV----------FKYR-R 230

  Fly   295 LGLLRTTYNLNEE--------PQL--SSAFYFDLA-----LRSFLTIKEMLQSGAWPKDMEYLNC 344
            ...|.|.:.||..        |.|  .|.|....|     |||.:...::  |..:|..: |.:|
  Fly   231 QAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAAQV--SPGYPLAI-YQDC 292

  Fly   345 DDFQGGNTPQRNLDLRDY----------FTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINV 399
            :.....:.....|:..||          |.....|..:    :..|...|..|.:|.     :|:
  Fly   293 NATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPH----IQDQFQSPVPGLTFA-----VNI 348

  Fly   400 LQIRGGSSVNSKS-IGKWISGLNSELIVKDEEQMKNLT---ADTVYRIFTVVQAPF--------- 451
            ......|...:|: :..|.|        ..|.::.|.|   |...:||.|....|:
  Fly   349 SAGYYSSEHEAKTDLAAWSS--------VGEMRLLNETISPARRFFRIGTAESIPWSYLRREEGT 405

  Fly   452 --IMRDETAPKGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADI 514
              ::||.:....::|||||.|..::..::|::.|...|.|..|.::|.|:|:|:|..|:..:.|.
  Fly   406 GELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDF 470

  Fly   515 GLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSFL 579
            .:.::.:.:|||.||||..|||:..||:|.:::|...:|||||:|||...|||.|:||...|:.:
  Fly   471 AIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVWLSIVAALVGTAIM 535

  Fly   580 MWIFDRWSPYSYQNNREKYKDDEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLF 644
            :|..|::||||.:|||:.|  ....|||.|:|..||.:||.||||||||||.:|||::.|.:|||
  Fly   536 IWFMDKYSPYSSRNNRQAY--PYACREFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLF 598

  Fly   645 GFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIW 709
            ..:::|::||||||||||.|:.|||:||:.||:|.:|.|..:..|....||..|...|...|.:|
  Fly   599 VVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMW 663

  Fly   710 KDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATLDEAVARVRNSTAATGFAFLGD 774
            |:|:||.|   .:..|..:||||:.::|..:..|:..::..|...|..|.| ::.....:||:.|
  Fly   664 KELALNAS---KDFKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANV-DAHENADYAFIHD 724

  Fly   775 ATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDE 839
            :.:|:|....||:|..|||.|:.:|||:||||||||.|:.:.|||.|...|..|:||.|:| |..
  Fly   725 SAEIKYEITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYW-NQS 788

  Fly   840 ALAKCDKPEDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKN----PRIIDVAEANA 900
            .|..|...||| :||:::::|||||....|:.:|.:||..|..:|:.::|    .::..|.:::.
  Fly   789 NLPNCPLSEDQ-EGITLESLGGVFIATLFGLVLAMMTLGMEVLYYKKKQNALEITQVRPVNDSSG 852

  Fly   901 ERSNAADHP 909
            ...|::..|
  Fly   853 SGGNSSTAP 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	76/416 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	167/408 (41%)
		Lig_chan	565..870	CDD:278489	135/304 (44%)
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	168/409 (41%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	135/305 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132669at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.920