DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and GluRIIE

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster

Alignment Length:	982	Identity:	230/982 - (23%)
Similarity:	392/982 - (39%)	Gaps:	275/982 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FLSLLSSFSLEIAA---------------------------QTTQNINVLFINEVDNEPAAKAVE 54
            |:.|.|.||:.|:.                           |.|:.:|::|.:.:|  .|.:.|.
  Fly     6 FVILWSLFSIHISVNWAQYENFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAID--VANQEVG 68

  Fly    55 VVLTYLKKNIRYGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETV 119
            ..||.||:.:.||     |:.::.....::|...|...:..| .:....||:
  Fly    69 TSLTSLKEEVNYG-----DAYQSYGKLCRMLETGIAGVFGPS-SRHTAVHLM------------- 114

  Fly   120 KSFTQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMP-PADIIPEAIRSIVIHMNITNAAI 183
             |...|:.:|.| .||           :.|..:.:.|.  | ||| :.:|:.|::...|.|....
  Fly   115 -SICDAMDIPHI-YSY-----------MSENAEGFNLH--PHPAD-LAKALYSLITEFNWTRFIF 163

  Fly   184 LYDDSFVMDHKYKSLLQNIQTR-----HVITAIAKDGK--REREEQIEKLRNLDINNFFILGT-- 239
            ||:.:     :|.::|..:.|.     .|||.:..|.:  ...::.:.::|....|...::|:
  Fly   164 LYESA-----EYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSE 223

  Fly   240 --------LQSIRMVLESVKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLG 296
                    .|.:.::.|..|  |...|..:|:....|.:.|..  |.|
  Fly   224 TMPEFLNQAQQVGIINEDYK--YIIGNLDFHSFDLEEYKYSEA--NIT----------------- 267

  Fly   297 LLRTTYNLNEEPQLSSAFYFDLALRSF----LTIKEMLQSGAWPKDMEYLNCDDFQGGNTP---- 353
                                  .||.|    :.:||:|....:|.|.     |:|:.|:.|
  Fly   268 ----------------------GLRLFSPEKMAVKELLMKLGYPTDQ-----DEFRNGSCPITVE 305

  Fly   354 ----------------------------QRNLDLRDYFTKITEPTSYGTF-------DLVTQSTQ 383
                                        ||...:||      :.:|:..:       |.:.....
  Fly   306 MALTYDAVQLFAQTLKNLPFKPMPQNCSQRTESVRD------DGSSFKNYMRTLRLTDRLLTGPI 364

  Fly   384 PFNGHSFMKFEMDINVLQIRGGSSVNSKSIGKWISGLNSELIVKDEEQM---------------- 432
            .|.|:....:.:|:..||..|     ...:|.|           ||::.
  Fly   365 YFEGNVRKGYHLDVIELQPSG-----IVKVGTW-----------DEDRQYRPQRLAPTTAQFDSV 413

  Fly   433 -KNLTADTVYRIFTVVQAPFIMRDET-----APKGYKGYCIDLINEIAAIVHFDYTIQEVEDGK- 490
             .:|...|...:.:|...|:....||     ....|:||.:|||.|:|..:.|::|.  |..|.
  Fly   414 DNSLANKTFIILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNFTF--VNGGND 476

  Fly   491 FGNMDEN-GQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPS-S 553
            :|:.::: .:..|:::::|..:||:.:..:::.:|||..:|||:|:.:| ||.|:..:|...: .
  Fly   477 YGSYNKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNL-GIAILYLKPQKATPE 540

  Fly   554 LFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEE-KREFNLKECLWFCM 617
            ||.|:......||..:..::...|...:|..|.||..:.|.....::.|| :.:|.|...:||..
  Fly   541 LFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTT 605

  Fly   618 TSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLA-KQYKI 681
            .:|..||....||.||.|.||:.||.|..|:::|||||||||||:.:..:.:.|:|||| .:..:
  Fly   606 GALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGV 670

  Fly   682 LYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQE 746
            :|......|...:|                      :|:.|            ::|.||.:.|.|
  Fly   671 VYGAKKTGSTRNFF----------------------MTSAE------------ERYKKMNKFMSE 701

  Fly   747 AKLPATLD--EAVARVRNSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSH 809
            .....|.|  |.|.||:.:   |.:|||.::|.|.|.....|:|:.:|:....|.|.||:::...
  Fly   702 NPQYLTEDNMEGVNRVKTN---THYAFLMESTSIEYNTKRECNLKKIGDALDEKGYGIAMRKDWP 763

  Fly   810 LKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQSDG--ISIQNIGGVFIVIFVGIGM 872
            .:.:||||:|.|..:..|||:|.||| |:.....|...||..|.  :.:.|:.|||.|:.||
  Fly   764 HRGKFNNALLELQEQGVLEKMKNKWW-NEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVG--- 824

  Fly   873 ACITLVF 879
            :|..|::
  Fly   825 SCCALLY 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	80/446 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	123/409 (30%)
		Lig_chan	565..870	CDD:278489	98/310 (32%)
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	85/465 (18%)
		ANF_receptor	51..382	CDD:279440	76/426 (18%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	124/411 (30%)
		Lig_chan	551..824	CDD:278489	97/310 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462881
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.840