DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir25a and Ir7c

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster

Alignment Length:	474	Identity:	89/474 - (18%)
Similarity:	172/474 - (36%)	Gaps:	93/474 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   443 IFTVVQAPFIM--RDETAPKGYKGYCID--LINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGI 503
            :.|....|:::  .|...|.|...:.|:  :...:|..::|...:.|.:|...|.:..:|.:.||
  Fly   218 VATFEHRPYVIIEDDPKTPGGRSIHGIEGLIFRSLAERMNFTIKLVEQKDKNRGEILPDGNFTGI 282

  Fly   504 VKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPS--SPSSLFKFLTVLETNVW 566
            :|.::|.:.::..........|.   |..:|........|::..||  |.|.:.:........:|
  Fly   283 LKMMVDGEVNLTFVCFMYSKARS---DLMLPSTSYTSFPIVLVVPSGGSISPMGRLTRPFRYIIW 344

  Fly   567 LCILAAYFFTSFLMWIFDRWSPYSYQN------NREKYKDDEEKREFNLKECLWFCMTSLTPQGG 625
            .|||.:..|...|:.:....:....:|      ||..:..            :|..:.      |
  Fly   345 SCILVSLIFGFVLICLLKITALPGLRNLVLGRRNRLPFMG------------MWASLL------G 391

  Fly   626 GEA---PKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDD-LAKQYKILYAP- 685
            |.|   |:....|.:...|.|...|:.|:||..|...|....:.:|::||.: |||.|:....|
  Fly   392 GLALYNPQRNFARYILVMWLLQTLILRAAYTGQLYLLLQDVEMRSPIKSLSEVLAKDYEFRILPA 456

  Fly   686 ----LNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQE 746
                ...|...|.|..:.::|:..|.      |.|.            |.|          .:..
  Fly   457 LRTIFKDSMPTTNFHAVLSLEESLYR------LRDE------------DDP----------GITV 493

  Fly   747 AKLPATLDEAVARVRNSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLK 811
            |.|..|:::             |.| ....:.|:|.:....|......|..:|:       |:.|
  Fly   494 ALLQPTVNQ-------------FDF-RSGPNKRHLTVLPDPLMTAPLTFYMRPH-------SYFK 537

  Fly   812 DQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQSDGISIQNIGGVFIVIFVGIGMACIT 876
            .:.:..|:.:::...:.:.::.:....:.::|....|.:.  :||..:.|:|:.......:|.|.
  Fly   538 RRIDRLIMAMMSSGIVARYRKMYMDRIKRVSKRRNLEPKP--LSIWRLSGIFVCCAGLYLVALIV 600

  Fly   877 LVFEYWWYRYRKNPRIIDV 895
            .:.|.....:|:..|..:|
  Fly   601 FILEILTTNHRRLRRAFNV 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378
		PBP2_iGluR_putative	438..836	CDD:270435	77/413 (19%)
		Lig_chan	565..870	CDD:278489	59/319 (18%)
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	14/61 (23%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	59/318 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463076
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740