DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and Grik3

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001106187.1	Gene:	Grik3 / 298521	RGDID:	71027	Length:	919	Species:	Rattus norvegicus

Alignment Length:	976	Identity:	257/976 - (26%)
Similarity:	413/976 - (42%)	Gaps:	232/976 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 LTYLKKNIRYGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKS 121
            |||..:.|.:.     ||.||.|.        .|::.|..:       :.:.....|..:..|:|
  Rat    79 LTYDIQRIHFH-----DSFEATKK--------ACDQLALGV-------VAIFGPSQGSCTNAVQS 123

  Fly   122 FTQALGLPTISASYGQQGDLRQWR--DLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAIL 184
            ...||.:|.|..         :|:  .||. |..:.:.:.|....:..||..:|..:...:|.::
  Rat   124 ICNALEVPHIQL---------RWKHHPLDN-KDTFYVNLYPDYASLSHAILDLVQSLKWRSATVV 178

  Fly   185 YDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSIRMVLES 249
            ||||..:          |:.:.:|.|.::...|      .|:|.|.|::       ...|.:|:.
  Rat   179 YDDSTGL----------IRLQELIMAPSRYNIR------LKIRQLPIDS-------DDSRPLLKE 220

  Fly   250 VKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLGLLRTT---YNLNEEPQLS 311
            :|     |...:..|......:::|      :..:.||.....:....:.||   |.|:.||..
  Rat   221 MK-----RGREFRIIFDCSHTMAAQ------ILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYR- 273

  Fly   312 SAFYFDLALRSF--LTIKEMLQSGAWPK-DMEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYG 373
               |..:.|..|  |.:.....|....| .||.|..       .|:....|.|..........|.
  Rat   274 ---YSGVNLTGFRILNVDNPHVSAIVEKWSMERLQA-------APRAESGLLDGVMMTDAALLYD 328

  Fly   374 TFDLVTQSTQ----------------------------------------PFNGHSFMKFEMDIN 398
            ...:|:...|                                        .||..|.::.:.|::
  Rat   329 AVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLD 393

  Fly   399 VLQIRGGSSVNSKSIGKW--ISGLNSELIVKDEEQMKNLTADTVYR---IFTVVQAPFIM---RD 455
            ::.::   ....:.:|.|  ..|||...:.|.  :..|:|.....|   :.|:::.||:|   .|
  Rat   394 IISLK---EDGLEKVGVWSPADGLNITEVAKG--RGPNVTDSLTNRSLIVTTLLEEPFVMFRKSD 453

  Fly   456 ET--APKGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQADIGLGS 518
            .|  ....::||||||:.|:|.|:.|.|.|:.|||||:|..|:.|||||:||:|:|.:||:.:..
  Rat   454 RTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAP 518

  Fly   519 MSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPS-SLFKFLTVLETNVWLCILAAYFFTSFLMWI 582
            :::...||..|||:.|:..| |::|:.::|:..: |:|.||..|..::|:.:|.||...|.::::
  Rat   519 LTITHVREKAIDFSKPFMTL-GVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFV 582

  Fly   583 FDRWSPYSYQNNREKYKDDE-EKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGF 646
            ..|:|||.:.:........| .:..|.|....||.|.||..||....||.||.|::...||.|..
  Rat   583 IARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTL 647

  Fly   647 IIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKD 711
            |||:||||||||||||.|:::|::|.||||||.||.|..:...:.||:|
  Rat   648 IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFF---------------- 696

  Fly   712 LSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPATL----DEAVARVRNSTAATGFAFL 772
                      ::||::.::        |||..|  :..|:.|    :|.:.|    |....:|.|
  Rat   697 ----------KKSKISTFE--------KMWAFM--SSKPSALVKNNEEGIQR----TLTADYALL 737

  Fly   773 GDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKN 837
            .::|.|.|:...||:|..:|.....|.|.|....||..:|:...|||.|..:.:|..:|||||:.
  Rat   738 MESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRG 802

  Fly   838 DEALAKCDKPED-QSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRIIDVAEANAE 901
                :.|.:.|: ::..:.||.|||:|||:..|:.::.:..|.|: .|:.||          .||
  Rat   803 ----SGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEF-IYKLRK----------TAE 852

  Fly   902 R------SNAAD----------------HPGKLV--DGVILGHS-------GEKFEKSKAALRPR 935
            |      |..||                .|..:|  |.||..|:       |:.......:|.|.
  Rat   853 REQRSFCSTVADEIRFSLTCQRRLKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMSCSTSLAPV 917

  Fly   936 F 936
            |
  Rat   918 F 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	77/418 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	144/411 (35%)
		Lig_chan	565..870	CDD:278489	103/310 (33%)
Grik3	NP_001106187.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	77/415 (19%)
		ANF_receptor	55..398	CDD:279440	72/393 (18%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	144/408 (35%)
		Lig_chan	564..832	CDD:278489	103/311 (33%)
		Glutamate binding	690..692		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350189
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740