DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir25a and Gria4

DIOPT Version :9

Sequence 1:	NP_001260049.1	Gene:	Ir25a / 33683	FlyBaseID:	FBgn0031634	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001106655.1	Gene:	Gria4 / 29629	RGDID:	61863	Length:	902	Species:	Rattus norvegicus

Alignment Length:	976	Identity:	272/976 - (27%)
Similarity:	442/976 - (45%)	Gaps:	206/976 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ILWLLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTYLKKNIR---YGLSVQL 72
            :|...||..|...     |..::..|..|||...|.|..|..:.:.|.....|..   :.|...:
  Rat     9 VLLFSGFWGLAMG-----AFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHV 68

  Fly    73 DSIEANKSDAKVLLEAICNKYATSI------EKKQTPHLILDTTKSGIASETVKSFTQALGLPTI 131
            |:||...|.|  :..|.|::|:..:      ..|::.|             |:.||..||.:..|
  Rat    69 DNIETANSFA--VTNAFCSQYSRGVFAIFGLYDKRSVH-------------TLTSFCSALHISLI 118

  Fly   132 SASYGQQGDLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILYDDSFVMDHKYK 196
            :.|:..:|:           .:::||:.|.   :..|:.|::.|........|||    .|..|
  Rat   119 TPSFPTEGE-----------SQFVLQLRPS---LRGALLSLLDHYEWNCFVFLYD----TDRGY- 164

  Fly   197 SLLQNIQTR------HVITAIAKDG--------------KREREE-----QIEKLRNLDINNFFI 236
            |:||.|..:      || :||..:.              :|:.::     :||:|:|:
  Rat   165 SILQAIMEKAGQNGWHV-SAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNI------- 221

  Fly   237 LGTLQSIRMVLESVKPAYFERNFAWHAITQNEG--EISSQR-----DNAT----IMFMKPMAYTQ 290
               |:.|..|.:.||        .:|.|..|.|  :||.:|     .|.|    :.|..||. |:
  Rat   222 ---LEQIVSVGKHVK--------GYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMV-TK 274

  Fly   291 YRDRLGLL-RTTYNLNE-EPQLSSAFYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDDFQGGNTP 353
            ..||...| :..|..:| .|:.:||..:|    ..|.:.|..:|      :.....|..:.||..
  Rat   275 LMDRWKKLDQREYPGSETPPKYTSALTYD----GVLVMAETFRS------LRRQKIDISRRGNAG 329

  Fly   354 Q----------RNLDLRDYF--TKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDINVLQIRGGS 406
            .          :.:|:....  .:|...|....||           |...:....::|.:::
  Rat   330 DCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFD-----------HYGRRVNYTMDVFELK--- 380

  Fly   407 SVNSKSIGKWISGLNSELIVKDEEQMKNLTADTVYR---IFTVVQAPFIM--RDETAPKG---YK 463
            |...:.:|.| :.::..::::|...:.|.||....|   :.|::::|::|  ::....:|   |:
  Rat   381 STGPRKVGYW-NDMDKLVLIQDMPTLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYE 444

  Fly   464 GYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQ-WNGIVKKLMDKQADIGLGSMSVMAEREI 527
            |||:||.:|||..:...|.|..|.|||:|..|.:.: |||:|.:|:..:|:|.:..:::...||.
  Rat   445 GYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREE 509

  Fly   528 VIDFTVPYYDLVGITIMMQRP-SSPSSLFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSY 591
            ||||:.|:..| ||:||:::| .|...:|.||..|...:|:||:.||...|.::::..|:|||.:
  Rat   510 VIDFSKPFMSL-GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW 573

  Fly   592 QNNR-EKYKD---DEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASY 652
            .... |..|:   |:...||.:...|||.:.:...||...:|::||||:|...||.|..|||:||
  Rat   574 HTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSY 638

  Fly   653 TANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDS 717
            ||||||||||.|:.:|:||.:|||||.:|.|..|:..|...:|
  Rat   639 TANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFF---------------------- 681

  Fly   718 LTAVERSKLAVWDYPVSDKYTKMWQAMQEAK---LPATLDEAVARVRNSTAATGFAFLGDATDIR 779
                .|||:||        |.|||..|:.|:   ...|..|.|||||.|...  ||||.::|...
  Rat   682 ----RRSKIAV--------YEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGK--FAFLLESTMNE 732

  Fly   780 YL-QLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAK 843
            |: |...||...||.....|.|.:|..:||.|::..|.|:|.|..:..|:|||.|||.:.   .:
  Rat   733 YIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDK---GE 794

  Fly   844 CDK----PEDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRIIDVAEANAERSN 904
            |..    .:|::..:|:.|:.|||.::..|:|:|.:..:.|: .|:.|...:.:.:..:.|.|:.
  Rat   795 CGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEF-CYKSRAEAKRMKLTFSEAIRNK 858

  Fly   905 A 905
            |
  Rat   859 A 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	93/444 (21%)
		PBP2_iGluR_putative	438..836	CDD:270435	151/415 (36%)
		Lig_chan	565..870	CDD:278489	112/316 (35%)
Gria4	NP_001106655.1	PBP1_iGluR_AMPA_GluR4	28..398	CDD:107383	95/448 (21%)
		ANF_receptor	39..380	CDD:279440	87/415 (21%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	152/420 (36%)
		Lig_chan	546..825	CDD:278489	112/317 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350176
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840